Fundus Near Infrared Fluorescence Correlates with Fundus Near Infrared Reflectance

Weinberger, A; Lappas, Alexandra; Kirschkamp, T.; Mazinani, Babac; Huth, J.; Mohammadi, Babak; Walter, Peter

doi:10.1167/iovs.05-1104

Cited by 111 publications

(87 citation statements)

References 11 publications

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“…19 Increased NIA corresponds to increased melanin levels (eg, in choroidal nevi), reduced NIA to deficient RPE cells in chloroquine retinopathy, agerelated macular degeneration, or Stargardt disease. [18][19][20][21] Three possible mechanisms could explain the altered NIA distribution in RP. First, an increase of melanin, melanolysosomes, or melanolipofuscin content in the RPE cell may occur.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Choroidal melanin is an additional, minor source of NIA. 19 NIA abnormalities have been reported in age-related macular degeneration, 18,19 Stargardt disease, 20 chloroquine retinopathy, 21 some forms of RP, 22,23 and Usher syndrome. 24 Both imaging methods, FAF and NIA, are non-invasive without any application of dye and can be repeated frequently if necessary.…”

Section: Introductionmentioning

confidence: 99%

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Lipofuscin- and melanin-related fundus autofluorescence visualize different retinal pigment epithelial alterations in patients with retinitis pigmentosa

Kellner

Weber

et al. 2008

Eye

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Aims To compare melanin-related nearinfrared fundus autofluorescence (FAF; NIA, excitation 787 nm, emission 4800 nm) with lipofuscin-related FAF (excitation 488 nm, emission 4500 nm) in retinitis pigmentosa (RP). Methods Thirty-three consecutive RP patients with different modes of inheritance were diagnosed clinically, with full-field ERG, and if possible with molecular genetic methods. FAF and NIA imaging were performed with a confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2). Results Rings of increased FAF were present within an area of preserved retinal pigment epithelium (RPE) at the posterior pole (31/33). Rings of increased NIA were located in the same region as rings of increased FAF. In contrast to FAF, NIA showed a precipitous decline of NIA peripheral to the ring. In larger areas of preserved NIA (11/31), pericentral and foveal NIA were of similar intensity with an area of lower NIA in between. In smaller areas of preserved NIA (20/31), NIA was homogeneous from the perifovea to the fovea. In one patient without a ring of increased FAF, NIA distribution was normal. In the remaining patient with severely advanced RP, no residual RPE as well as no FAF and NIA were detectable. Conclusion Characteristic features for FAF and NIA alterations in a heterogeneous group of RP patients indicate a common pathway of RPE degeneration. Patterns of NIA and FAF indicate different pathophysiologic processes involving melanin and lipofuscin. Combined NIA and FAF imaging will provide further insight into the pathogenesis of RP and noninvasive monitoring of future therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipofuscin- and melanin-related fundus autofluorescence visualize different retinal pigment epithelial alterations in patients with retinitis pigmentosa

Kellner

Weber

et al. 2008

Eye

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“…[5][6][7][8] In this study we describe the NIR-R, NIR-AF and BW-AF characteristics of choroidal nevi, using confocal scanning laser ophthalmoscope (cSLO), and how these findings correlate to one another.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared reflectance and autofluorescence imaging characteristics of choroidal nevi

Vallabh

Sahni

Parkes

et al. 2016

Eye

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Purpose To report near-infrared reflectance (NIR-R), near-infrared autofluorescence (NIR-AF) and blue wave autofluorescence (BW-AF) appearance of choroidal nevi using a confocal scanning laser ophthalmoscope (cSLO). Patients and methods NIR-R, NIR-AF and BW-AF images of choroidal nevi were compared with color fundus photos (CF). Images were graded as hyperreflective if reflectance was much greater than background, hyporeflective if less than background, and isoreflective if the same as the background. Results Forty-two nevi of 39 patients were imaged. When compared with CF, nevi could be identified on 95% (40/42) NIR-R images (95% CI: 83.5-99.3). On NIR-R 71% (30/42) demonstrated hyperreflectance and 24% (10/42) were hyporeflective. Hyperreflectivity was demonstrated in 96% (23/24) of NIR-AF images (95% CI: 79.1-99.9) and 34% (14/41) of BW-AF images (95% CI: 20.0-50.5). On NIR-R, 29/40 (73%) were apparently smaller in comparison with CF and 11/40 (28%) had the same area. A correlation was found between NIR-R and NIR-AF (P = 0.02) but not with BW-AF (P = 0.15). Conclusions Nevi can be visualized well using NIR-R and NIR-AF imaging modalities, but are less frequently visible using BW-AF. These changes may be related to melanin within the choroid or chronic changes of the overlying retinal pigment epithelium.

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“…16,17,42,43 Anormalidades de nIA foram reportadas em pacientes com anormalidades genéticas ou degenerativas do EPR, como Doença de Stargardt, retinite pigmentosa, degeneração macular relacionada à idade, retinopatia por cloroquina e coriorretinopatia serosa central (Figura 8). 16,17,43,44 Reflectância com Luz "Infravermelha" (near-Infrared Reflectance, nIR)…”

Section: Autofluorescência Com Luz "Infravermelha" (Near-infrared Autunclassified

“…A correlação entre nIR e nIA indica que parte da fluorescência observada por luz "infravermelha" possa ser pseudofluorescência, com influência direta na imagem obtida (Figura 10). 44 A alta definição da imagem obtida com os novos aparelhos de OCT espectral tem levado alguns autores a comparar o corte seccional tomográfico ao corte histológico. 9,10,[57][58][59] Não obstante, a correlação direta com a histologia do tecido ainda não é conhecida em todas as situações fisiológicas e patológicas, e comparações devem ainda ser vistas com algum ceticismo.…”

Section: Figuraunclassified

Avaliação ocular multimodal em doenças heredodistróficas e degenerativas da retina

Ferrara¹,

Calucci²,

Oréfice³

et al. 2009

Rev. bras.oftalmol.

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RESUMOA tomografia de coerência óptica incorporou-se gradativamente ao contemporâneo arsenal diagnóstico em Oftalmologia, passando a exercer papel fundamental na investigação e condução de doenças oculares, particularmente na especialidade de Retina e Vítreo. A disponibilização comercial da nova geração de aparelhos, chamada de tomografia de coerência óptica "espectral", baseada em conceito físico distinto que permite a aquisição de imagens em alta velocidade, marcou o início de uma nova era desta tecnologia de investigação auxiliar. Adicionalmente, sua recente combinação com o oftalmoscópio de varredura a laser confocal (confocal scanning laser ophthalmoscope) vem propiciando a aquisição de imagens tomográficas guiadas em tempo real pelos diferentes modos de imagem (autofluorescência de fundo, reflectância com luz "infravermelha" e angiografia com fluoresceína ou indocianina verde). A avaliação ocular multimodal (multimodal fundus imaging) permite a correlação real e minuciosa de achados da morfologia retiniana e do epitélio pigmentar com dados de estudos angiográficos e de autofluorescência ou reflectância, propiciando assim inferências valiosas sobre a fisiologia do tecido. Neste artigo, discutimos brevemente as possíveis implicações da avaliação ocular multimodal na prática da especialidade de Retina e Vítreo.

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Fundus Near Infrared Fluorescence Correlates with Fundus Near Infrared Reflectance

Cited by 111 publications

References 11 publications

Lipofuscin- and melanin-related fundus autofluorescence visualize different retinal pigment epithelial alterations in patients with retinitis pigmentosa

Lipofuscin- and melanin-related fundus autofluorescence visualize different retinal pigment epithelial alterations in patients with retinitis pigmentosa

Near-infrared reflectance and autofluorescence imaging characteristics of choroidal nevi

Avaliação ocular multimodal em doenças heredodistróficas e degenerativas da retina

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