Fungaemia due to rare yeasts in paediatric intensive care units: A prospective study

Kaur, Harsimran; Rudramurthy, Shivaprakash M.; Jayashree, Muralidharan; Peters, Nitin James; Ray, Pallab; Samujh, Ram; Ghosh, Anup; Chakrabarti, Arunaloke

doi:10.1111/myc.13297

Cited by 8 publications

(6 citation statements)

References 49 publications

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“…According to the 22 publications of C. auris infection, comprising 256 children [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], reviewed herein, the most common type of invasive infection was bloodstream infection (94%, 194/206 patients with available data on the infection site) ( Table 3 and Table S1 ). The duration of candidemia was not reported in most studies and was available for only seven patients; the duration ranged between 7 and 11 days [ 16 , 20 , 36 ].…”

Section: Clinical Spectrum Of C Auris Infectionmentioning

confidence: 99%

“…Publications were reviewed and selected based on their quality and pertinence. Following exclusion of suspected repetitive studies, the search yielded 23 publications that reported C. auris incidents in children [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Twelve publications included both adult and pediatric patients [ 17 , 19 , 20 , 23 , 24 , 26 , 27 , 28 , 32 , 35 , 36 , 37 ]; of them, one did not provide specific details of the pediatric patients and was excluded [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…Six provided limited specific details of the pediatric patients [ 17 , 19 , 24 , 27 , 37 ]. Five publications included data of other Candida species with limited data specific to C. auris infections [ 18 , 26 , 29 , 30 , 35 ]. Overall, 22 studies were included, involving about 250 C. auris cases in children.…”

Section: Introductionmentioning

confidence: 99%

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Navigating the New Reality: A Review of the Epidemiological, Clinical, and Microbiological Characteristics of Candida auris, with a Focus on Children

Ashkenazi‐Hoffnung

Danziger

2023

JoF

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During the past decade, Candida auris emerged across the world, causing nosocomial outbreaks in both pediatric and adult populations, particularly in intensive care settings. We reviewed the epidemiological trends and the clinical and microbiological characteristics of C. auris infection, focusing on the pediatric population. The review is based on 22 studies, which included about 250 pediatric patients with C. auris infection, across multiple countries; neonates and premature babies were the predominant pediatric patient group affected. The most common type of infection reported was bloodstream infection, which was associated with exceptionally high mortality rates. Antifungal treatment varied widely between the patients; this signifies a serious knowledge gap that should be addressed in future research. Advances in molecular diagnostic methods for rapid and accurate identification and for detection of resistance may prove especially valuable in future outbreak situations, as well as the development of investigational antifungals. However, the new reality of a highly resistant and difficult-to-treat pathogen calls for preparedness of all aspects of patient care. This spans from laboratory readiness, to raising awareness among epidemiologists and clinicians for global collaborative efforts to improve patient care and limit the spread of C. auris.

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Section: Clinical Spectrum Of C Auris Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Navigating the New Reality: A Review of the Epidemiological, Clinical, and Microbiological Characteristics of Candida auris, with a Focus on Children

Ashkenazi‐Hoffnung

Danziger

2023

JoF

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“…There were seven residents colonized by C. pararugosa , which was first reported in 2017 to cause bloodstream infections [ 27 ]. Hence, it is worth noting that in addition to those common species that cause diseases in humans, some rare species that were recovered in the present study such as Candida norvegensis [ 28 ], C. utilis [ 29 ], Cystobasidium minutum ( Rhodotorula minute ) [ 30 ], Exophiala dermatitidis [ 31 , 32 , 33 ], Lodderomyces elongisporus [ 34 , 35 ], Magnusiomyces capitatus [ 36 ], and Trichosporon mucoides [ 37 ] have been reported to cause invasive infections in humans.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Yeast Species and Risk Factors of Oral Colonization after Oral-Care Education among the Residents of Nursing Homes

Lin

Chiang

et al. 2022

JoF

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Most yeasts causing infections in humans are part of commensal microflora and etiological agents of different infections when hosts become susceptible, usually due to becoming immunocompromised. The colonization of potentially pathogenic microbes in the oral cavity is increased by poor oral hygiene. This follow-up survey was conducted approximately two months after providing information on proper oral care at 10 nursing homes in Taiwan. Among the 117 of 165 residents colonized by yeasts, 67 were colonized by more than one yeast species. A total of 231 isolates comprising eight fungal genera and 25 species were identified. Candida albicans (44.6%) was the dominant species, followed by Candida glabrata (17.7%), Candida parapsilosis (8.7%), Candida tropicalis (7.8%), and Candida pararugosa (7.3%). Residents having a yeast colony-forming unit >10 (OR, 8.897; 95% CI 2.972–26.634; p < 0.001) or using a wheelchair (OR, 4.682; 95% CI 1.599–13.705; p = 0.005) were more likely to be colonized by multiple species. By comparing before and after oral-care education, dry mouth (OR, 3.199; 95% CI 1.448–7.068; p = 0.011) and having heart disease (OR, 2.681; 95% CI 1.068–6.732; p = 0.036) emerged as two independent risk factors for increased density of colonizing yeast.

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“…He recovered after fluconazole therapy. Kaur et al (2021) performed a systematic epidemiologic study on fungaemia caused by rare yeasts, and from a total of 127 isolates, 43 were identified as W. anomalous. Perez-Traves et al (2021) investigated factors potentially related to virulence and pathogenicity in a Galleria mellonella model for a collection of clinical and food/environmental isolates of D. hansenii, K. marxianus and W. anomalous.…”

Section: Wickerhamomyces Anomalusmentioning

confidence: 99%

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 15: suitability of taxonomic units notified to EFSA until September 2021

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2022

EFS2

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The qualified presumption of safety (QPS) approach was developed to provide a generic pre‐evaluation of the safety of biological agents. The QPS approach is based on an assessment of published data for each agent, with respect to its taxonomic identity, the body of relevant knowledge and safety concerns. Safety concerns are, where possible, confirmed at the species/strain or product level and reflected by ‘qualifications’. The QPS list was updated in relation to the revised taxonomy of the genus Bacillus, to synonyms of yeast species and for the qualifications ‘absence of resistance to antimycotics’ and ‘only for production purposes’. Lactobacillus cellobiosus has been reclassified as Limosilactobacillus fermentum. In the period covered by this statement, no new information was found that would change the status of previously recommended QPS taxonomic units (TU)s. Of the 70 microorganisms notified to EFSA, 64 were not evaluated: 11 filamentous fungi, one oomycete, one Clostridium butyricum, one Enterococcus faecium, five Escherichia coli, one Streptomyces sp., one Bacillus nakamurai and 43 TUs that already had a QPS status. Six notifications, corresponding to six TUs were evaluated: Paenibacillus lentus was reassessed because an update was requested for the current mandate. Enterococcus lactis synonym Enterococcus xinjiangensis, Aurantiochytrium mangrovei synonym Schizochytrium mangrovei, Schizochytrium aggregatum, Chlamydomonas reinhardtii synonym Chlamydomonas smithii and Haematococcus lacustris synonym Haematococcus pluvialis were assessed for the first time. The following TUs were not recommended for QPS status: P. lentus due to a limited body of knowledge, E. lactis synonym E. xinjiangensis due to potential safety concerns, A. mangrovei synonym S. mangrovei, S. aggregatum and C. reinhardtii synonym C. smithii, due to lack of a body of knowledge on its occurrence in the food and feed chain. H. lacustris synonym H. pluvialis is recommended for QPS status with the qualification ‘for production purposes only’.

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Fungaemia due to rare yeasts in paediatric intensive care units: A prospective study

Cited by 8 publications

References 49 publications

Navigating the New Reality: A Review of the Epidemiological, Clinical, and Microbiological Characteristics of Candida auris, with a Focus on Children

Navigating the New Reality: A Review of the Epidemiological, Clinical, and Microbiological Characteristics of Candida auris, with a Focus on Children

Distribution of Yeast Species and Risk Factors of Oral Colonization after Oral-Care Education among the Residents of Nursing Homes

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 15: suitability of taxonomic units notified to EFSA until September 2021

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