Fungal biocatalysts for labdane diterpene hydroxylation

Candida species are responsible for causing invasive candidiasis with high mortality rate and their resistance to available antifungal drugs is a major clinical challenge. Biotransformation process of the labdane diterpene ent-labd-8( 17)-en-15,18-dioic acid (1) carried out with Cunninghamella elegans afforded five new derivatives (compounds 2-6). Unusual regioselective hydroxylation of the methyl group at the C-20 position of labdanetype diterpene was achieved and all compounds were subjected to cytotoxicity and antifungal evaluations. Compound 1 and its derivatives were not cytotoxic to normal (MCF-10A) and tumor (MCF-7) cell lines. Compounds 2 and 3 exhibited fungistatic activity against all tested Candida strains at lower concentrations than fluconazole. Both compounds also showed the strongest fungicidal activity against C. albicans, which is the most prevalent fungal agent involved in candidemia.

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Production of More Potent Anti‐Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans

Sousa

Teixeira

Freitas

et al. 2022

Chemistry & Biodiversity

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Biotransformation of progesterone by endophytic fungal cells immobilized on electrospun nanofibrous membrane

dos Santos,

Andre,

dos Anjos

et al. 2023

Folia Microbiol

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Oxidative potential of two Brazilian endophytic fungi from Handroanthus impetiginosus towards progesterone

et al. 2022

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Fungal biocatalysts for labdane diterpene hydroxylation

Cited by 6 publications

References 54 publications

Production of More Potent Anti‐Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans

Production of More Potent Anti‐Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans

Biotransformation of progesterone by endophytic fungal cells immobilized on electrospun nanofibrous membrane

Oxidative potential of two Brazilian endophytic fungi from Handroanthus impetiginosus towards progesterone

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