“…4 In research settings in South Africa, utilising optimal amphotericin B-based treatments, acute mortality of CM is between 24 and 37%. 5,6 Lessells et al suggest that, in routine care settings, mortality rates are higher. 1 From their study conducted at Hlabisa Hospital in rural Kwazulu-Natal, they report 41% in-hospital mortality (all of which deaths occurred within 30 days of admission), which is in keeping with data from Johannesburg, where only 33% of CM patients were known to be alive and under follow-up at 12 weeks (Govender N, unpublished).…”