Fungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women

Quatresooz, Pascale; Piérard-Franchimont, C; Szepetiuk, Grégory; Devillers, Céline; Pierard, Gérald

doi:10.1517/14656560903201699

Cited by 13 publications

(13 citation statements)

References 37 publications

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“…Foot amputation after bacterial infection is still a serious complication in patients with diabetes. 15 Our results indicate an increased degree of skin xerosis linked with the duration of diabetes associated with desquamation and pruritus in our diabetic patients. Emollient therapy can correct all these alterations.…”

Section: Discussionsupporting

confidence: 49%

“…Skin dryness and reduced elasticity may lead to cracking in the skin followed by bacterial invasion and infection. Foot amputation after bacterial infection is still a serious complication in patients with diabetes 15 . Our results indicate an increased degree of skin xerosis linked with the duration of diabetes associated with desquamation and pruritus in our diabetic patients.…”

Section: Discussionmentioning

confidence: 53%

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Importance of treatment of skin xerosis in diabetes

Seité

Khemis

Rougier

et al. 2011

Acad Dermatol Venereol

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 53%

Importance of treatment of skin xerosis in diabetes

Seité

Khemis

Rougier

et al. 2011

Acad Dermatol Venereol

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“…It was reported that morbidly obese patients have dry skin and impaired skin barrier repair 1 . In addition, it was also reported that xerosis of feet commonly occurs in menopausal women as well as diabetic patients due to corneocyte accumulation 14 . In our study, the incidence of xerosis in two groups was close to each other.…”

Section: Resultsmentioning

confidence: 99%

Erişkin Obez Hastalarda Dermatolojik Bulgular

Demirci¹,

Bilen²,

Aktürk³

et al. 2016

Kocaeli Üniversitesi Sağlık Bilimleri Dergisi

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Objectives: There are only a few studies about the dermatological findings of obese patients in the literature. However, we aimed to investigate the dermatological findings of obese patients and the relationship of these conditions with age, menopause, number of pregnancies, and insulin resistance in our study. Material and Methods:This study included 119 patients with a body mass index higher than 30 kg/m 2 and 122 normal weight individuals as a control group. Also, the insulin resistance was calculated of the patients. The prevalences of dermatoses were compared between the two groups. Results:The most common dermatologic finding in both groups was striae. But, there was not statistically significant difference between two groups. Plantar hyperkeratosis was found in 47.1% and 7.4% of patients in the study and control groups, respectively and the difference was statistically significant. Also the frequencies of acrochordon, acanthosis nigricans, keratosis pilaris and intertrigo were significantly higher in the obese group. Varicose veins were more common in the control group (36.9%) compared with the obese group (31.9%). There was no statistically significant difference between the patients with and without insulin resistance in terms of frequency of plantar hyperkeratosis, intertrigo, keratosis pilaris, varicose veins, striae, acrochordon and xerosis in the obese group. However, it was striking that there was insulin resistance in 13 of the 14 patients who had acanthosis nigricans. Conclusions:Our study showed that some dermatological findings were significantly more common in obese patients. So, prevention of obesity is important in terms of prevention of these dermatoses. Key words: Obesity, skin manifestations, insulin resistanceAmaç: Obez hastalardaki dermatolojik bulgularla ilişkili olarak literatürde çok az sayıda çalışma bulunmaktadır. Bu nedenle çalışmamızda obez hastalardaki deri bulgularını ve bunların yaş, menapoz, gebelik sayısı ve insülin direnci ile ilişkilerinin araştırması amaçlanmıştır. Gereç ve Yöntemler:Bu çalışma vücut kitle indeksi 30 kg/m 2 nin üzerinde olan 119 hastayı ve kontrol grubu olarak normal kiloya sahip 122 bireyi kapsamaktadır. Dematozların görülme sıklıkları iki grup arasında karşılaştırılmıştır. Bulgular:Her iki grupta da en sık rastlanan dermatolojik bulgu stria idi. Ancak iki grup arasında istatistiksel anlamlı bir farklılık yoktu. Plantar hiperkeratoz çalışma ve kontrol gruplarında sırasıyla % 47,1 ve % 7,4 oranlarında bulundu ve farklılık istatistiksel olarak anlamlıydı. Aynı zamanda akrokordon, akantozis nigrikans, keratozis pilaris ve intertrigo sıklığı obez grupta anlamlı olarak yüksekti. Variköz venler kontrol grubunda (% 36,9) obez grup (% 31,9) ile karşılaştırıldığında daha sık gözlendi. Çalışma grubunda insülin direnci olan ve olmayan olgular plantar hiperkeratoz, intertrigo, keratozis pilaris, variköz venler, stria, akrokordon ve kserosis görülme sıklıklarına göre karşılaştırıldığında istatistiksel olarak anlamlı bir farklılık yoktu. Ancak akantozis nigrikans olan...

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“…Wzmacniają barierę naskórkową, przywracają prawidłowy poziom lipidów w skórze, redukują złuszczanie, zmiany wypryskowe, nadkażenia bakteryjne i grzybicze, łagodzą także świąd skóry. Profilaktyka suchej skóry i świą-du jest niezwykle prosta, wymaga jednak od pacjenta systematyczności w używaniu emolientów, któ-rych regularne stosowanie wzmacnia i odbudowuje barierę naskórkową, redukuje złuszczanie, zmiany wypryskowe, nadkażenia bakteryjne i grzybicze oraz świąd skóry [41][42][43][44]. Mimo że emolienty stanowią grupę dermokosmeceutyków szeroko stosowanych w lecznictwie dermatologicznym, doniesień na temat ich skuteczności w terapii suchej skóry i zapobieganiu powikłaniom u diabetyków jest stosunkowo niewiele.…”

Section: Pielęgnacja Skóry Cukrzycowejunclassified

Molecular factors involved in skin dryness in diabetic patients

Bednarski¹,

Lesiak²

2016

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STRESZCZENIECukrzyca, która jest chorobą przewlekłą oraz układową, dotyka aż 8,3% populacji ogólnej i staje się poważnym problemem klinicznym i finansowym dla systemów opieki zdrowotnej na świecie. Powikłania cukrzycy obejmują zarówno uszkodzenia wielu narządów wewnętrz-nych, jak i zmiany skórne, które mogą wyprzedzać kliniczne objawy cukrzycy. Ponadto skóra diabetyków często jest podrażniona i przesuszona, co przyczynia się do zwiększonego ryzyka występowania infekcji skórnych. Niemniej niewiele dotychczas wiadomo na temat molekularnych podstaw zmian zachodzących w skórze w przebiegu cukrzycy. Wszystkie prowadzone do tej pory badania koncentrują się wokół uszkodzenia bariery naskórkowej, zaburzeń integralności naskórka oraz zaburzeń funkcjonowania gruczołów łojowych. Innym, złożonym problemem jest sama pielęgnacja skóry osób chorujących na cukrzycę. Kompleksowe zrozumienie procesów zachodzących na poziomie komórkowym mogłoby pozwolić na odkrycie nowych markerów monitorujących skuteczność stosowanego leczenia zmian skórnych oraz nowych preparatów pielęgnacyjnych. ABSTRACTDiabetes is a chronic systemic disease affecting 8.3% of the general population, thus constituting an important clinical and financial problem for healthcare systems throughout the world. Complications of diabetes damage both many internal organs and skin. Skin complications of diabetes can anticipate its clinical symptoms. Diabetic skin, irritated and dry in many cases, is susceptible to skin infections. However, there is little known about molecular changes in skin in diabetes. Many studies are concentrated on epidermal barrier damage, dysfunction of epidermis integrity and dysfunction of sebaceous glands. Another complex problem is skin care in diabetic patients. A profound understanding of cellular-level processes in diabetes could lead to the discovery of new therapy efficacy markers and new skin care products. SŁOWA KLUCZOWE:cukrzyca, sucha skóra, emolienty.

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Fungal chitin-glucan scaffold for managing diabetic xerosis of the feet in menopausal women

Abstract: The increased moisturization of the SC of the sole probably improves the desquamation process and reduces xerosis of the soles.

Cited by 13 publications

References 37 publications

Importance of treatment of skin xerosis in diabetes

Importance of treatment of skin xerosis in diabetes

Erişkin Obez Hastalarda Dermatolojik Bulgular

Molecular factors involved in skin dryness in diabetic patients

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