Fungal-Derived Nanoparticles as Novel Antimicrobial and Anticancer Agents

Abstract

In order to control microbial resistance against commonly used antibiotics, it is indispensable to develop novel and efficient antimicrobial agents. For this purpose, metallic nanoparticles (mainly inorganic) with their antimicrobial activites represent an effective solution for this global problem. However, synthesis of nanoparticles involves the use of expensive, poisonous and dangerous chemicals responsible for different biological and environmental hazards. This fact increases the necessity of developing environmentfriendly procedure by means of green synthesis (using plants) and extra-biological methods (using microbes such as bacteria and fungi). More recently, metallic nanoparticles, derived from fungal sources, have demonstrated their potential not only as a new-generation antimicrobial agents but also as anticancer agents. Therefore, this chapter is aimed to explore the various nanoparticles producing fungi with ultimate objective of elucidating the possible (i) mechanism of biosynthesis of metallic NPs by various fungi and (ii) mode of action of these mycosynthesized NPs on bacterial cell. This chapter would certainly increase our knowledge about interaction of nanoparticles with bacterial cell for their use in health biotechnology.

Creating silver nanoparticles through the biogenic synthesis process using marine fungi Aspergillus flavus OQ651270: Examining their characterization and conducting biological studies.

“…After exposing MCF-7 cells (human breast adenocarcinoma) to the nanoparticles, a low IC50 value (121.23 µg/cm3) was obtained, indicating high cytotoxicity and the potential for tumor control [51]. Fungi-made silver nanoparticles exhibited strong anticancer activity against many tumor cells lines, with IC 50 values consistent with those previously reported [37,39,[52][53][54][55].…”

Biogenic synthesis of silver nanoparticles from marine fungi Aspergillus flavus OQ651270: Their characterization and biological studies

“…After exposing MCF-7 cells (human breast adenocarcinoma) to the nanoparticles, a low IC50 value (121.23 µg/cm3) was obtained, indicating high cytotoxicity and the potential for tumor control [51]. Fungi-made silver nanoparticles exhibited strong anticancer activity against many tumor cell lines, with IC 50 values consistent with those previously reported [37,39,[52][53][54][55].…”

Multifaceted Applications of Silver Nanoparticles Synthesized from Marine Fungus<em> Aspergillus flavus</em> MK4: Antimicrobial, Anticancer, and Wound-Healing Properties

“…The nanoparticles showed great cytotoxicity and the possibility of efficient tumor control when they were exposed to MCF-7 cells, as evidenced by a low IC50 value of 121.23 µg/cm3 [60]. Silver nanoparticles produced by fungi demonstrated robust anticancer activity against various tumor cell lines, exhibiting IC50 values that align with those reported in prior studies [39,41,[61][62][63][64]. In Figures 8A-B, we can see the results demonstrating that silver nanoparticles accelerate the healing process of wounds.…”