Fungal endocarditis

Nadir, Erez; Rubinstein, Ethan

doi:10.1007/s11908-004-0048-8

Cited by 27 publications

(7 citation statements)

References 48 publications

(38 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In immunosuppressed cancer patients, the presence of structural heart disease, especially the presence of a prosthetic valve, increases the risk of fungal endocarditis 4,25,41 . In the current study, the only case of C. tropicalis endocarditis was seen in a non-neutropenic patient with non-Hodgkin lymphoma who had a prosthetic aortic valve.…”

Section: Discussionmentioning

confidence: 99%

Culture-Positive and Culture-Negative Endocarditis in Patients With Cancer

et al. 2006

View full text Add to dashboard Cite

Endocarditis is uncommon in patients with cancer. The characteristics of culture-positive (CPE) and culture-negative endocarditis (CNE) in high-risk cancer patients are not known; therefore we sought to evaluate the disease characteristics in patients with endocarditis at a comprehensive cancer center. We retrospectively reviewed the transthoracic (TTE) and transesophageal (TEE) echocardiograms obtained from 654 consecutive cancer patients in whom endocarditis was suspected between 1994 and 2004. Endocarditis was confirmed in 45 (7%) of 654 patients using modified Duke University criteria based on information obtained from hospital records and computerized data systems. In 21 (95%) of 22 cases, TEE examinations were diagnostic, and 16 (42%) of 38 patients with initially nondiagnostic TTE studies had the diagnosis confirmed by TEE study; this difference between diagnostic TEE and initial nondiagnostic TTE was significant (p < 0.0001). Among the 26 (58%) patients with CPE, Staphylococcus aureus (35%) was the most common organism isolated, followed by coagulase-negative Staphylococcus species (23%). Eighteen (78%) of 23 patients with a central venous catheter had CPE, whereas only 8 (36%) of 22 patients without a central venous catheter had CPE (odds ratio [OR], 6.3; 95% confidence interval [CI], 1.69-23.53; p < 0.006). Vegetations were larger in patients with CPE than in patients with CNE (median +/- standard deviation, 10 +/- 8.8 vs. 8.7 +/- 3.9 mm). Fifteen patients (58%) with CPE and 10 (53%) with CNE had embolic complications. We note that cutaneous and septic pulmonary emboli were more common in patients with CPE than in patients with CNE (31% vs. 11% and 15% vs. 0%, respectively), whereas embolic cerebrovascular and fatal embolic coronary events were more common in patients with CNE than in those with CPE (37% vs. 12% and 21% vs. 0%, respectively; p = 0.026). The 4-week endocarditis-attributable death rate did not differ significantly between the groups (CPE, 15% vs. CNE, 32%; p = 0.28). On stepwise multivariate regression analysis, patients with neutropenia (OR, 22.52; 95% CI, 2.25-225.48; p < 0.008) and those with embolic cerebrovascular events (OR, 17.07; 95% CI, 1.63-178.45; p < 0.01) had an increased probability of death due to endocarditis. The clinical spectrums of CPE and CNE differed in these patients with cancer. In patients with CNE, embolic cerebrovascular and fatal myocardial infarction were relatively common.

show abstract

Section: Discussionmentioning

confidence: 99%

Culture-Positive and Culture-Negative Endocarditis in Patients With Cancer

et al. 2006

View full text Add to dashboard Cite

show abstract

“…There are various reasons why a blood culture may be negative in the face of endocarditis (hence presumed bacteremia). The main reasons for culture negativity are pretreatment with antibiotics prior to the blood culture; nonbacterial etiologies for the endocarditis (such as fungal etiology, for instance); right-sided endocarditis, which may not be as bacteremic in systemic circulation; and the presence of implanted devices such as pacemakers or implantable defibrillators (246)(247)(248). The microbial etiologic agent of the endocarditis being fastidious and thus not easily grown on standard culture medium is one of the most important reasons why blood culture may be negative in the case of endocarditis (86,177,249).…”

Section: Bartonella and Disease Disease Syndromes Associated With Barmentioning

confidence: 99%

Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis

et al. 2017

View full text Add to dashboard Cite

Since the reclassification of the genus in 1993, the number of species has grown from 1 to 45 currently designated members. Likewise, the association of different species with human disease continues to grow, as does the range of clinical presentations associated with these bacteria. Among these, blood-culture-negative endocarditis stands out as a common, often undiagnosed, clinical presentation of infection with several different species. The limitations of laboratory tests resulting in this underdiagnosis of endocarditis are discussed. The varied clinical picture of infection and a review of clinical aspects of endocarditis caused by are presented. We also summarize the current knowledge of the molecular basis of pathogenesis, focusing on surface adhesins in the two species that most commonly cause endocarditis, and. We discuss evidence that surface adhesins are important factors for autoaggregation and biofilm formation by species. Finally, we propose that biofilm formation is a critical step in the formation of vegetative masses during-mediated endocarditis and represents a potential reservoir for persistence by these bacteria.

show abstract

“…The infected intra-cardiac tumour mass may have originated from a cardiac valve. Children with congenital heart defects, with surgery using vascular patches and grafts, or patients with valvular disease, with intravenous devices and antibiotic use, are at greater risk for a fungal endocarditis [42, 43]. Our patient had a vascular line in situ with its tip lying in the right atrium.…”

Section: Discussionmentioning

confidence: 99%

Acute Cardiac Failure due to Intra-Atrial Mass Caused by Zygomycetes in an Immunocompromised Paediatric Patient

Glind

Gidding

Verlaat

et al. 2010

Case Reports in Medicine

View full text Add to dashboard Cite

Cardiac zygomycosis can be a critical condition with sudden onset of severe congestive heart failure followed by severe hemodynamic deterioration. We report a fatal course of disseminated fungal infection with a massive intra-atrial thrombosis caused by a zygomycete, in a five year old boy treated for acute lymphoblastic leukaemia. In addition, we discuss the literature concerning infections caused by zygomycetes involving the heart. Prognosis is poor. A high index of suspicion and an aggressive diagnostic and therapeutic approach with the prompt start of preemptive antifungal therapy are key factors to improve outcome.

show abstract

Fungal endocarditis

Cited by 27 publications

References 48 publications

Culture-Positive and Culture-Negative Endocarditis in Patients With Cancer

Culture-Positive and Culture-Negative Endocarditis in Patients With Cancer

Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis

Acute Cardiac Failure due to Intra-Atrial Mass Caused by Zygomycetes in an Immunocompromised Paediatric Patient

Contact Info

Product

Resources

About