Fungal granuloma of the brain caused by Cladosporium bantianum—a case report and review of literature

Singh, Sumit; Singh, Prabhjeet; Sarkar, Chitra; Goel, Vinay; Srivastava, Trilochan; Sharma, Monica; Behari, Madhuri

doi:10.1016/j.jns.2004.10.002

Cited by 12 publications

(4 citation statements)

References 11 publications

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“…by either PCR or morphology. This dimorphic fungus is an emerging, difficult-to-treat cause of cerebral infections in immunocompromised and immunocompetent persons [25][26][27][28][29][30]. Cerebral mixed fungal infections (cases 6 and 7 of the present study) or with a fungus and a bacterium are considered rare, but have been previously observed in mammals (e.g.…”

Section: Discussionmentioning

confidence: 99%

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Tauber

Eiffert

Kellner

et al. 2014

Neuropathology Appl Neurobio

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Section: Discussionmentioning

confidence: 99%

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Tauber

Eiffert

Kellner

et al. 2014

Neuropathology Appl Neurobio

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“…As formas invasivas mais comuns são as pulmonares e cerebrais (Castro et al, 2013;Singh et al, 2005).…”

Section: Patogênese E Manifestações Clínicasunclassified

“…No entanto, outros órgãos podem ser afetados, como por exemplo, coração, intestino, ossos, baço, fígado e rins. Acredita-se que a principal forma de infecção é a inalação (Singh et al, 2005; Sidrim e Rocha, 2012).…”

Section: Patogênese E Manifestações Clínicasunclassified

Cladosporium spp: Morfologia, infecções e espécies patogênicas

2017

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ResumoO gênero Cladosporium spp compreende grande número de fungos dematiáceos com distribuição mundial e que estão entre os fungos de ambiente mais comuns. São frequentemente isolados como contaminantes, no entanto, algumas espécies são patogênicas e toxigênicas para os seres humanos, estando associados a infecções superficiais da pele e dos tecidos moles e incluem sepse disseminada com elevada mortalidade. Cladoporium spp são aero-alérgenos e causam graves doenças alérgicas do trato respiratório, bem como lesões intrabrônquicas. Atualmente, as espécies de Cladosporium spp de interesse médico associadas com doença humana são C. cladosporioides, C. herbarum, C. oxysporum e C. sphaerospermum. No caso de infecções por Cladosporium spp, a terapia é prolongada e varia de acordo com a síndrome clínica. Sendo essencial o conhecimento a cerca desse gênero, para melhor diagnóstico e tratamento adequado. Esta revisão de literatura teve como objetivo reunir informações sobre as características gerais e morfológicas, patologias, aspectos clínicos e principais espécies patogênicas das infecções causadas por esse gênero. Palavras-chave: Feo-hifomicoses, Fungos dematiáceos, Micoses oportunistas. Cladosporium spp: Morphology, infections and pathogenic species AbstractThe genus Cladosporium spp comprises a large number of dematiaceous fungi with a world-wide distribution and are among the most common air-borne fungi. They are frequently isolated contaminants and some species are pathogenic and toxigenic to humans and are associated with superficial infections of the skin and soft tissues, including disseminated sepsis with high mortality. In addition, Cladoporium spp. are aero-allergens and cause serious allergic diseases of the respiratory tract, as well as intrabronchial lesions. Currently, the Cladosporium spp species of medical interest associated with human disease are C. cladosporioides, C. herbarum, C. oxysporum and C. sphaerospermum. In the case of Cladosporium spp infections, the therapy is prolonged and varies according to the clinical syndrome. Knowledge about this genre is essential for better diagnosis and appropriate treatment. This literature review to gather information about the general and morphological characteristics, pathologies, clinical aspects and main pathogenic species of the infections caused by this genus.

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“…5 Several species are plant pathogens, 6 and some others are allergenic to human. 1,[7][8][9][10][11] Prolonged exposure to high concentrations of Cladosporium spores can weaken the immune system allowing opportunistic bacteria and viruses to infect the host. 12,13 Cladosporium sensitization is associated with severe or life-threatening asthma.…”

Section: Introductionmentioning

confidence: 99%

Detection and quantification of Cladosporium in aerosols by real-time PCR

et al. 2006

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Cladosporium is one of the most common airborne molds found in indoor and outdoor environments. Cladosporium spores are important aeroallergens, and prolonged exposure to elevated spore concentrations can provoke chronic allergy and asthma. To accurately quantify the levels of Cladosporium in indoor and outdoor environments, two real-time PCR systems were developed in this study. The two real-time PCR systems are highly specific and sensitive for Cladosporium detection even in a high background of other fungal DNAs. These methods were employed to quantify Cladosporium in aerosols of five different indoor environments. The investigation revealed a high spore concentration of Cladosporium (10(7) m(-3)) in a cow barn that accounted for 28-44% of the airborne fungal propagules. In a countryside house that uses firewood for heating and in a paper and pulp factory, Cladosporium was detected at 10(4) spores m(-3), which accounted for 2-6% of the fungal propagules in the aerosols. The concentrations of Cladosporium in these three indoor environments far exceeded the medical borderline level (3000 spores m(-3)). In a power station and a fruit and vegetable storage, Cladosporium was found to be a minor component in the aerosols, accounted for 0.01-0.1% of the total fungal propagules. These results showed that monitoring Cladosporium in indoor environments is more important than in outdoor environments from the public health point of view. Cladosporium may not be the dominant fungi in some indoor environments, but its concentration could still be exceeding the threshold value for clinical significance. The methods developed in this study could facilitate accurate detection and quantification of Cladosporium for public health related risk assessment.

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Fungal granuloma of the brain caused by Cladosporium bantianum—a case report and review of literature

Cited by 12 publications

References 11 publications

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair

Cladosporium spp: Morfologia, infecções e espécies patogênicas

Detection and quantification of Cladosporium in aerosols by real-time PCR

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