Fungal Infection in Heart Transplant Recipients With Severe Sepsis: Single-Center Experience

Chou, Nai‐Kuan; Chi, Nai‐Hsin; Wu, I-Ju; Huang, Shu‐Chien; Chen, Yih‐Sharng; Yu, Hsi‐Yu; Tsao, C.-I.; Ko, Wen‐Je; Sun, Hsin‐Yun; Chang, Shan-Chwen; Chu, Shu‐Hsun; Wang, Shoei‐Shen

doi:10.1016/j.transproceed.2010.02.049

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…Our 1.7% rate of IA was at the low end of the 1–14% range reported for HTx recipients [1,2,7–10,14], and it was less than that of several programs that have employed universal antifungal prophylaxis [2,7]. Moreover, only 1 of our HTx recipients was colonized with an Aspergillus species in the absence of IA, which was less common than at other centers reporting such data [7,15].…”

Section: Discussionmentioning

confidence: 76%

“…On the one hand, MODS is believed to predispose patients to IA and other opportunistic infections by inducing an initial inflammatory stage that results in a state of relative immunoparalysis [19]. At the same time, IA has been reported to cause sepsis and MODS in rare instances [14]. Lastly, IA was not suspected and antifungal therapy not initiated until culture results became positive after 2–6 days.…”

Section: Discussionmentioning

confidence: 99%

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Invasive aspergillosis among heart transplant recipients is rare but causes rapid death due to septic shock and multiple organ dysfunction syndrome

Shields

Nguyen

Shullo

et al. 2012

Scandinavian Journal of Infectious Diseases

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Between 2000 and 2011, proven or probable invasive aspergillosis (IA) was diagnosed in 1.7% (8/455) of heart transplant (HTx) recipients at our center, in the absence of antifungal prophylaxis. All patients had invasive pulmonary infections and 75% (6/8) were diagnosed during 2 separate 3-month periods. Cases were notable for their association with septic shock and multiple organ dysfunction syndrome (MODS) (75%, 6/8 each), non-specific clinical and radiographic findings, and rapid mortality despite mould-active antifungal therapy (88%, 7/8; occuring at a median 11 days after diagnosis). All patients had predisposing conditions known to be risk factors for IA. For patients with early IA (within 90 days of HTx), conditions included hemodialysis, thoracic re-operation, and the presence of another case in the institution within the preceding 3 months. For late-onset IA, conditions included hemodialysis and receipt of augmented immunosuppression. Clinicians should suspect IA in HTx recipients with risk factors who present with non-specific and unexplained respiratory syndromes, including those in septic shock and MODS, and institute prompt antifungal therapy without waiting for the results of cultures or other diagnostic tests.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Invasive aspergillosis among heart transplant recipients is rare but causes rapid death due to septic shock and multiple organ dysfunction syndrome

Shields

Nguyen

Shullo

et al. 2012

Scandinavian Journal of Infectious Diseases

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“…24,25 In heart transplant recipients incidence of cryptococcus is 3%, it manifests as sepsis and is associated with high mortality. 26,27 In renal transplant recipients incidence of cryptococcus is 2.8% manifests as cryptoccocal necrotizing soft tissue infection. 28 In liver transplant recipients the incidence is 2.4 % and liver failure is independently associated with Cryptoccocal meningitis mortality.…”

Section: Evidence Summarymentioning

confidence: 99%

Indian Antimicrobial Prescription Guidelines in Critically Ill Immunocompromised Patients

Kulkarni

Sengar

Chinnaswamy

et al. 2019

Indian Journal of Critical Care Medicine

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How to cite this article: Kulkarni AP, Sengar M, Chinnaswamy G, Hegde A, Rodrigues C, Soman R, Khilnani GC, Ramasubban S, Desai M, Pandit R, Khasne R, Shetty A, Gilada T, Bhosale S, Kothekar A, Dixit S, Zirpe K, Mehta Y, Pulinilkunnathil JG, Bhagat V, Khan MS, Narkhede AM, Baliga N, Ammapalli S, Bamne S, Turkar S, Bhat KV, Choudhary J, Kumar R, Divatia JV. Indian Journal of Critical Care Medicine 2019;23(Suppl 1): S64-S96.

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Diagnosis of Fungal Infection (Candida albicans) After Heart Transplantation in a Pediatric Case with Fever of Unknown Origin: Role of 99mTc-UBI SPECT/CT and 18F-FDG PET/CT

Malek

Hedayati

Maghsudi

et al. 2022

Nucl Med Mol Imaging

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Fungal Infection in Heart Transplant Recipients With Severe Sepsis: Single-Center Experience

Cited by 6 publications

References 6 publications

Invasive aspergillosis among heart transplant recipients is rare but causes rapid death due to septic shock and multiple organ dysfunction syndrome

Invasive aspergillosis among heart transplant recipients is rare but causes rapid death due to septic shock and multiple organ dysfunction syndrome

Indian Antimicrobial Prescription Guidelines in Critically Ill Immunocompromised Patients

Diagnosis of Fungal Infection (Candida albicans) After Heart Transplantation in a Pediatric Case with Fever of Unknown Origin: Role of 99mTc-UBI SPECT/CT and 18F-FDG PET/CT

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