Fungal Infection of the Nasal Cavity and Paranasal Sinuses: Review of 26 Cases

Al‐Bhlal, Lulu Ahmad

doi:10.5144/0256-4947.1996.615

Cited by 10 publications

(19 citation statements)

References 18 publications

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“…Although antimicrobial treatment may predispose cats to orbital mycosis, a causative association between the use of antimicrobials and orbital aspergillosis is unlikely given the common use of antimicrobials, the widespread presence of fungal organisms on the skin and mucosal surface of cats, and the rare occurrence of orbital mycosis 49 . Certainly, mycotic infections occur in humans with no history of oral antimicrobial use 12,50 …”

Section: Discussionmentioning

confidence: 99%

“…Immunosuppressed human patients are more likely to develop severe and disseminated invasive aspergillosis. However, systemic immunosuppression is not necessary for the development of nasal or paranasal aspergillosis 11–13 . Most cats with orbital aspergillosis have no systemic immunocompromising disorder and test serologically negative for FELV, FIV, and FIP.…”

Section: Discussionmentioning

confidence: 99%

“…The first report of a focal infection in the orbit and sinuses of a cat, due to Penicillium sp., dates back to 1980 10 . Immunocompetent humans typically present with a localized, noninvasive infection, in contrast to immunosuppressed human patients who are more likely to develop severe and usually fatal disseminated invasive aspergillosis 11–13 . Disseminated aspergillosis is an opportunistic infection in immunosuppressed cats and is reported secondary to diabetes mellitus, viral infections (feline leukemia virus, feline immunodeficiency virus, feline panleukopenia), or prior treatment with glucocorticoids or antibiotics 14 .…”

Section: Introductionmentioning

confidence: 99%

“…10 Immunocompetent humans typically present with a localized, noninvasive infection, in contrast to immunosuppressed human patients who are more likely to develop severe and usually fatal disseminated invasive aspergillosis. [11][12][13] Disseminated aspergillosis is an opportunistic infection in immunosuppressed cats and is reported secondary to diabetes mellitus, viral infections (feline leukemia virus, feline immunodeficiency virus, feline panleukopenia), or prior treatment with glucocorticoids or antibiotics. 14 In contrast to disseminated or systemic aspergillosis, sino-orbital infection is considered a local disease which can develop in immunocompetent feline patients.…”

Section: Introductionmentioning

confidence: 99%

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A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

Smith¹,

Hoffman

2010

Veterinary Ophthalmology

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Feline orbital aspergillosis is increasingly described in the published reports and may be an emerging disease. Orbital mycotic infections were diagnosed in three cats with exophthalmos, significant dorso-temporal globe deviation and pronounced resistance to retropulsion. Advanced imaging was performed in all three cases to evaluate the extent of disease as well as to obtain guided orbital biopsies in two cases. Surgical intervention in the form of a lateral orbitotomy was pursued in the first case with the other two cases treated with enucleation or medical management alone. The available published reports concerning sino-orbital aspergillosis are reviewed. Oral therapy with a novel triazole, voriconazole, was instituted in two cases. Although voriconazole was apparently effective against the fungal organisms, it is also resulted in adverse reactions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

Smith¹,

Hoffman

2010

Veterinary Ophthalmology

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“…Infections with these fungal organisms are known to increase in prevalence during rainy seasons. 13,14 Although host immunocompetence must be considered in humans and other animals that have nasal infections involving opportunistic fungi, systemic immunosuppression is not critical to the development of nasal or paranasal mycosis. 4 The Fusarium spp most commonly implicated in human disease include Fusarium solani (the most pathogenic), Fusarium moniliforme (verticillioides), and Fusarium oxysporum.…”

Section: Commentsmentioning

confidence: 99%

Pathology in Practice

Vascellari

Carminato²,

Danesi³

et al. 2011

javma

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Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence‐Based Review with Recommendations

Roland

Humphreys

et al. 2023

Int Forum Allergy Rhinol

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BackgroundAcute invasive fungal sinusitis (AIFS) is an aggressive disease that requires prompt diagnosis and multidisciplinary treatment given its rapid progression. However, there is currently no consensus on diagnosis, prognosis, and management strategies for AIFS, with multiple modalities routinely employed. The purpose of this multi‐institutional and multidisciplinary evidence‐based review with recommendations (EBRR) is to thoroughly review the literature on AIFS, summarize the existing evidence, and provide recommendations on the management of AIFS.MethodsThe PubMed, EMBASE, and Cochrane databases were systematically reviewed from inception through January 2022. Studies evaluating management for orbital, non‐sinonasal head and neck, and intracranial manifestations of AIFS were included. An iterative review process was utilized in accordance with EBRR guidelines. Levels of evidence and recommendations on management principles for AIFS were generated.ResultsA review and evaluation of published literature was performed on 12 topics surrounding AIFS (signs and symptoms, laboratory and microbiology diagnostics, endoscopy, imaging, pathology, surgery, medical therapy, management of extrasinus extension, reversing immunosuppression, and outcomes and survival). The aggregate quality of evidence was varied across reviewed domains.ConclusionBased on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidisciplinary team via a combination of surgery (including resection whenever possible), antifungal therapy, and correcting sources of immunosuppression. Higher quality (i.e., prospective) studies are needed to better define the roles of each modality and determine diagnosis and treatment algorithms.

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Fungal Infection of the Nasal Cavity and Paranasal Sinuses: Review of 26 Cases

Cited by 10 publications

References 18 publications

A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

A case series of unilateral orbital aspergillosis in three cats and treatment with voriconazole

Pathology in Practice

Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis: Multidisciplinary Consensus Statement and Evidence‐Based Review with Recommendations

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