Fungal infections after lung transplantation

Solé, Amparó; Salavert, Miguel

doi:10.1097/mcp.0b013e328326f410

Cited by 70 publications

(59 citation statements)

References 66 publications

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“…However, there is no uniformly accepted strategy, and different drugs are used in lung transplant centers throughout the world [58, 59]. They include nebulized amphotericin B, oral voriconazole, or itraconazole, alone or in combinations [59, 60]. Since the use of aerosolized medications may significantly reduce their toxic systemic effects and potential drug interactions, they are an attractive option [61].…”

Section: Trachobronchial Aspergillosismentioning

confidence: 99%

Tracheobronchial Manifestations ofAspergillusInfections

Krenke

Grabczak

2011

The Scientific World JOURNAL

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Human lungs are constantly exposed to a large number of Aspergillus spores which are present in ambient air. These spores are usually harmless to immunocompetent subjects but can produce a symptomatic disease in patients with impaired antifungal defense. In a small percentage of patients, the trachea and bronchi may be the main or even the sole site of Aspergillus infection. The clinical entities that may develop in tracheobronchial location include saprophytic, allergic and invasive diseases. Although this review is focused on invasive Aspergillus tracheobronchial infections, some aspects of allergic and saprophytic tracheobronchial diseases are also discussed in order to present the whole spectrum of tracheobronchial aspergillosis. To be consistent with clinical practice, an approach basing on specific conditions predisposing to invasive Aspergillus tracheobronchial infections is used to present the differences in the clinical course and prognosis of these infections. Thus, invasive or potentially invasive Aspergillus airway diseases are discussed separately in three groups of patients: (1) lung transplant recipients, (2) highly immunocompromised patients with hematologic malignancies and/or patients undergoing hematopoietic stem cell transplantation, and (3) the remaining, less severely immunocompromised patients or even immunocompetent subjects.

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Section: Trachobronchial Aspergillosismentioning

confidence: 99%

Tracheobronchial Manifestations ofAspergillusInfections

Krenke

Grabczak

2011

The Scientific World JOURNAL

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Section: Fungal Infectionsmentioning

confidence: 99%

“…It is most frequently isolated in patients after lungs transplantation, as it colonizes necrotic areas of lungs parenchyma [26]. The changes visible in the chest imaging are non-specific and include segmental or lobe parenchyma congestions [26]. The high definition chest CT shows in most of the cases bilateral, well separated nodules mainly in the lower lung lobes [26] [Figure 8].…”

Section: Fungal Infectionsmentioning

confidence: 99%

“…The changes visible in the chest imaging are non-specific and include segmental or lobe parenchyma congestions [26]. The high definition chest CT shows in most of the cases bilateral, well separated nodules mainly in the lower lung lobes [26] [Figure 8]. They may also be accompanied by other changes: mainly parenchyma congestions and shadings, less frequent are tree-in bud symptom and thickening of bronchial walls [26].…”

Section: Fungal Infectionsmentioning

confidence: 99%

“…The high definition chest CT shows in most of the cases bilateral, well separated nodules mainly in the lower lung lobes [26] [Figure 8]. They may also be accompanied by other changes: mainly parenchyma congestions and shadings, less frequent are tree-in bud symptom and thickening of bronchial walls [26]. Rarely in the cases of lungs cadidiasis halo sign or nodules occur.…”

Section: Fungal Infectionsmentioning

confidence: 99%

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Radiological spectrum of pulmonary infections in patients post solid organ transplantation.

Sułkowska

Palczewski²,

Gołębiowski³

2012

Pol J Radiol

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SummaryPneumonia remains an important source of morbidity and mortality in transplant recipients. Since clinical findings are nonspecific and cultures may be time-consuming, imaging plays an important role in establishing the probable etiology of pneumonia. Plain films are used as an initial study. However, they have a limited capacity in differentiating the causative factors. HRCT is used as a problem-solving tool in patients with unclear plain film findings and/or no response to treatment. The main advantage of HRCT is a very detailed depiction of the lung parenchyma. Even though HRCT findings are not always specific, there are several sings that are more common in certain types of pneumonia. The aim of the article is to present radiological findings suggestive of a particular causative microorganism and show how they can narrow the differential diagnosis when coupled with clinical data.

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