Fungal Infections in Primary and Acquired Immunodeficiencies

Georgiadou, Sarah P.; Kontoyiannis, Dimitrios P.

doi:10.1007/978-3-319-50842-9_1

Cited by 1 publication

(1 citation statement)

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“…Among the diverse applications of cationic chitosan derivatives to inhibit fungi, one of the most noticeable may be its disinfection control in clinics, hospitals and some medical environments. The prevalence of fungal infections is on the rise due to the prevalence of immunodeficiency diseases caused by organ transplantation, immunosuppressive therapy, built-in medical device therapy, radiotherapy and chemotherapy, and AIDS (Aslam, Hernandez, Thornby, Zeluff, & Darouiche, 2010;Badiee & Hashemizadeh, 2014;Georgiadou & Kontoyiannis, 2017;Lanternier et al, 2013). The occurrence of fungal resistance is the main reason for the poor anti-fungal treatment (Revie et al, 2018).…”

Section: Tablementioning

confidence: 99%

Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

Qin

Guo

2020

Carbohydrate Polymers

138

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The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.

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Section: Tablementioning

confidence: 99%