Fungal Infections in Solid-Organ Transplantation

Payá, Carlos V.

doi:10.1093/clind/16.5.677

Cited by 355 publications

(226 citation statements)

References 120 publications

(176 reference statements)

Supporting

Mentioning

209

Contrasting

Unclassified

Order By: Relevance

“…1,2 The most important reason for the high mortality is the difficulty in early diagnosis because of the low index of suspicion and nonspecific clinical and radiographic findings. Therefore, rapid and accurate diagnosis is essential for a good outcome.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Bronchoalveolar Lavage in Diagnosis of Fungal Infections in Liver Transplant Recipients

Tepeoğlu

Atılgan²,

Ozdemır³

et al. 2015

Exp Clin Transplant

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…1,2 These infections are associated with major morbidity and mortality. Therefore, rapid diagnosis of fungal infections in immunocompromised patients is important.…”

Section: Introductionmentioning

confidence: 99%

Role of Bronchoalveolar Lavage in Diagnosis of Fungal Infections in Liver Transplant Recipients

Tepeoğlu

Atılgan²,

Ozdemır³

et al. 2015

Exp Clin Transplant

View full text Add to dashboard Cite

“…Aspergillus and Candida species are the most common causes of invasive fungal infections in solid-organ transplant recipients. 13 These infections occur in 5% to 45% transplant recipients. 14,15 The incidence of fungal infections has been reported to be approximately 40% in the liver transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2014

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: We review the pathological findings as determined by autopsy of the liver allografts. Materials and Methods: We retrospectively analyzed 408 patients who had a liver transplant between January 1990 and December 2012. Thirteen of the 408 patients underwent postmortem examination. Clinicopathologic findings including the age at death, causes of death, and main pathological findings were evaluated. Results: The study group of 13 patients who underwent a liver transplant had a mean age of 29 years at the time of death. Mean survival was 6 ± 1 months (range, 10-72 mo). Ten of 13 patients (76.9%) died 90 days after the liver transplant. The remaining 3 patients died, 1 case in 1 year, in 2 cases after 1 year. Causes of the deaths were infection (9 cases), respiratory distress (1 cases), multiorgan failure (1 cases), primary graft failure (1 cases), and massive intra-abdominal bleeding (1 cases). The causes of the infection were bacterial infection in 6 cases (67%) and invasive fungal infection in other 3 cases (33%). The main pathological finding was hepatic infarction in 9 cases (69%). Bridging fibrosis (3 cases) and hematoma (1 case) were obtained in the remaining cases. Conclusions: Our results emphasize that infections are the main cause of death and hepatic infarction is the main histopathologic findings among these 13 patients within the first year of transplant. We consider postmortem examination to have important role in determining the primary graft failure and other causes that increased mortality in liver transplant recipients. An autopsy can provide understanding of the main causes and cause of death.

show abstract

“…Estas cifras reflejan la magnitud del problema en series publicadas mayoritariamente durante la década de los 90 [13][14][15][16] . Recientemente Pappas y cols., publicaron resultados de un registro prospectivo de EFI en 15 centros de trasplante en E.U.A., entre los años 2001 y 2006.…”

Section: Trasplantes De óRganos Sólidosunclassified

Profilaxis antifúngica en niños y adultos sometidos a trasplante de órganos sólidos y de precursores hematopoyéticos

Rabagliati¹,

Santolaya²

2012

Rev. chil. infectol.

View full text Add to dashboard Cite

Prophylaxis against fungal infections in solid organ and hematopoietic stem cells transplantationInvasive fungal infections are an important cause of morbidity and mortality in SOT and HSCT recipients. The main species involved are Candida spp. and Aspergillus spp, less frequently Cryptococcus spp., causal agents of mucormycosis and Fusarium spp. Usually occur within the first six months post-transplant, but they do it later, especially during episodes of rejection, which maintains the state of immune system involvement. Prophylaxis recommendations are specific to each type of transplant. In liver transplantation use of fluconazole is recommended only in selected cases by high risk factor for invasive fungal infections (A1). If the patient has a high risk of aspergillosis, there are some suggestions for adults population to use amphotericin B-deoxycholate, liposomal amphotericin B or caspofungin (C2) without being validated none of these recommendations in pediatric population. In adult lung transplant patients where the risk of aspergillosis is higher than in other locations, we recommend universal prophylaxis with itraconazole 200 mg/day, nebulised liposomal amphotericin B or voriconazole (C2), no validated recommendations for pediatrics. In HSCT, universal prophylaxis is recommended only in allogeneic and autologous selected cases. The most accepted indication is fluconazole (A1), and posaconazole (A1) or micafungin (A1) in selected cases with high risk of aspergillosis.Key words: Fungus, Candida, Aspergillus, yeasts, moulds, prophylaxis, amphotericin, fl uconazole, voriconaamphotericin, fluconazole, voriconazole, posaconazole, caspofungin, micafungin, transplants, solid organ transplantation, hematopoietic stem cells transplantation.Palabras clave: Hongos, Candida, Aspergillus, levaduras, hongos filamentosos, profilaxis, anfotericina, fluconazol, voriconazol, posaconazol, caspofungina, micafungina, trasplante, trasplante de órganos sólidos, trasplante de precursores hematopoyéticos. IntroducciónL as infecciones fúngicas constituyen una importante causa de morbilidad en los pacientes receptores de trasplantes de órganos sólidos (TOS) y trasplante de precursores hematopoyéticos (TPH) 1 , generando desafíos diagnósticos y terapéuticos, elevación de los costos de manejo y elevada mortalidad 2,3 . En los receptores de trasplantes, la enfermedad fúngica invasora (EFI) es provocada tanto por hongos levaduriformes como filamentosos, destacando Candida spp. y Aspergillus spp. 2-4 , menos frecuentemente Cryptococcus spp., agentes causales de mucormicosis 5,6 y Fusarium spp. 7 , infecciones por hongos endémicos como Histoplasma capsulatum, Coccidioides immitis, Paracoccidioides brasiliensis, y con menor cuantía dematiáceos como Cladosporium, Cladophialophora, Scopulariopsis, Alternaria, Curvularia y Bipolaris spp 8 .Existen diferencias en la frecuencia de EFI entre los distintos tipos de TOS y TPH; no obstante, algunas características son comunes: en ambos grupos la mayoría de las EFI son producidas por Candida spp. o ...

show abstract

Fungal Infections in Solid-Organ Transplantation

Cited by 355 publications

References 120 publications

Role of Bronchoalveolar Lavage in Diagnosis of Fungal Infections in Liver Transplant Recipients

Role of Bronchoalveolar Lavage in Diagnosis of Fungal Infections in Liver Transplant Recipients

Untitled

Profilaxis antifúngica en niños y adultos sometidos a trasplante de órganos sólidos y de precursores hematopoyéticos

Contact Info

Product

Resources

About