2014
DOI: 10.1016/j.fgb.2014.06.011
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Fungal model systems and the elucidation of pathogenicity determinants

Abstract: HighlightsHistory of seven fungal species used as models for studying development and pathogenicity.Outline of central stages of their life cycle and their infection processes.Molecular toolkits used to study different aspects of pathogenicity.Insight gained from genome sequencing projects.Current research trends and future challenges.

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Cited by 150 publications
(104 citation statements)
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References 239 publications
(298 reference statements)
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“…Fungal pathogens have evolved a variety of strategies for successful infection of target hosts (47,48). Fungal spores (conidia) of the insect pathogenic fungus, B. bassiana, will attempt to attach and initiate infection essentially anywhere on host cuticle, although preferential infection sites on some hosts have been observed (21,49,50).…”
Section: Discussionmentioning
confidence: 99%
“…Fungal pathogens have evolved a variety of strategies for successful infection of target hosts (47,48). Fungal spores (conidia) of the insect pathogenic fungus, B. bassiana, will attempt to attach and initiate infection essentially anywhere on host cuticle, although preferential infection sites on some hosts have been observed (21,49,50).…”
Section: Discussionmentioning
confidence: 99%
“…gossypii is one of the simplest filamentous fungal species studied, which due to its close relationship to yeast, small genome size and easy genetic manipulation arose as an attractive model to study fungal developmental biology (reviewed in Perez-Nadales et al, 2014;Schmitz and Philippsen, 2011;Wendland and Walther, 2005). Its life cycle (Fig.…”
Section: Life Cyclementioning
confidence: 99%
“…Industrially exploited for more than 20 years due to its natural ability to overproduce riboflavin, A. gossypii is considered a remarkable example of the sustainable white biotechnology business model (Kato and Park, 2012;Lim et al, 2001;Stahmann et al, 2000;zu Berstenhorst et al, 2009). Nevertheless, the scientific prominence of A. gossypii is not limited to its biotechnological potential, since it is also extensively used as a model organism in fungal developmental and evolutionary biology studies (Perez-Nadales et al, 2014;Schmitz and Philippsen, 2011;Wendland and Walther, 2005). Its industrial relevance and the basic knowledge accumulated along the years promoted the development of molecular and in silico tools that, in turn, have allowed the continuous engineering of A. gossypii strains with improved riboflavin production traits, either through random or rational approaches.…”
Section: Introductionmentioning
confidence: 99%
“…Immunocompromised patients can acquire IA through the inhalation of conidia that invade the pulmonary alveoli, translocating into the blood and subsequently disseminating to other organs and niches throughout the human body. Aspergillus fumigatus is the main causal agent of aspergillosis (1,2), causing around 65% of all Aspergillus invasive infections, and is the most encountered species in pulmonary infections (3)(4)(5). Aspergillosis is a multifactorial disease, with several phenotypes influencing the final outcome of the disease.…”
mentioning
confidence: 99%