Fungal Osteomyelitis of the Temporal Bone: A Review of Reported Cases

Hanna, Ehab; Hughes, Gordon B.; Eliachar, Isaac; Wanamaker, John R.; Tomford, Walter

doi:10.1177/014556139307200807

Cited by 27 publications

(13 citation statements)

References 18 publications

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“…In addition, the pathogenicity of Aspergillus may be enhanced by disruption of the normal bacterial flora in the ear, either by recent or concurrent broad-spectrum antibiotics. 10…”

Section: Discussionmentioning

confidence: 99%

Fungal malignant otitis externa treated with hyperbaric oxygen

Ling

Sader

2008

International Journal of Infectious Diseases

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“…In addition, the pathogenicity of Aspergillus may be enhanced by disruption of the normal bacterial flora in the ear, either by recent or concurrent broad-spectrum antibiotics. 10…”

Section: Discussionmentioning

confidence: 99%

Fungal malignant otitis externa treated with hyperbaric oxygen

Ling

Sader

2008

International Journal of Infectious Diseases

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“…In the aspergillus-related skull base osteomyelitis, the treatment of choice is intravenous amphotericin. 1 The optimal dose and duration is unknown. However, the therapy should be prolonged because early cessation is associated with a high rate of recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…However, the therapy should be prolonged because early cessation is associated with a high rate of recurrence. 1 This patient was treated aggressively for 4 weeks with intravenous amphotericin B (1 mg/ kg/day), followed by 400 mg oral fluconazole daily. The fluconazole was continued for approximately 6 months.…”

Section: Discussionmentioning

confidence: 99%

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Malignant otitis externa caused byMalassezia sympodialis

et al. 2000

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Background Malignant otitis externa caused by fungal infections is rare. A review of the literature showed only 9 cases, and the causative fungus in all cases was Aspergillus. This article reports an unusual case caused by Malassezia sympodialis. Methods A 53‐year‐old man with non‐insulin dependent diabetes presented with malignant otitis externa. He deteriorated despite treatment with intravenous antipseudomonal therapy and surgical debridement. Microbiologic tests revealed M. sympodialis. He responded rapidly to intravenous amphotericin. Results Systemic human infections caused by M. sympodialis have not been reported. M. furfur systemic infection is rare and has been associated lipid hyperalimentation by means of a central catheter. Only 1 other case of M. fungemia without these associated risk factors has been reported. Conclusions The first case of malignant otitis externa caused by M. sympodialis is presented. It highlights the difficulty of initial biologic diagnosis and the need for lipid‐enriched media to grow this fastidious organism. © 2000 John Wiley & Sons, Inc. Head Neck 22: 87–89, 2000.

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“…or Aspergillus spp. (129). In this review of 9 cases, almost all patients had received broad-spectrum antibiotics for prolonged periods for presumed malignant external otitis which is caused by P. aeruginosa, and almost half the patients had a previous history of chronic suppurative otitis media, a condition from which both fungi and various antifungal organisms have been isolated; P. aeruginosa, Alcaligenes spp., Proteus spp., Mycobacteria, and Bacteroides spp.…”

Section: The Earmentioning

confidence: 98%