Peritonitis is the most common complication leading to peritoneal dialysis (PD) withdrawal. 1 PD-related peritonitis usually resolves with antibiotic therapy. However, some cases become refractory to treatment. Some of these cases are accompanied by tunnel infection, intestinal perforation, or intraperitoneal abscesses. 2 An abdominal abscess attributing to peritonitis was reported in 0.7% of peritonitis episodes. 3 In particular, a splenic abscess complicated with PD-related peritonitis is a rare disease, with only two previous reports. 4,5 Splenic abscess itself is also rare, with a frequency between 0.2% and 0.7% reported in autopsy-based studies. 6 Its major etiologies include endocarditis or hematogeneous seeding such as intra-abdominal sepsis, chest infection, or osteomyelitis. 7