Fungal rhinosinusitis in patients with chronic sinusal disease

Dall’Igna, Celso; Palombini, Bruno Carlos; Anselmi, Fabio; Araújo, Elisabeth; Dall'Igna, Daniela Pernigotti

doi:10.1016/s1808-8694(15)31237-4

Cited by 22 publications

(30 citation statements)

References 16 publications

(36 reference statements)

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“…The features of CGFRS are similar to CIFRS cases in our study quite in concordance to the features described by Aribandi et al [9] in his review in which a hyperattenuating soft tissue collection is seen at non contrast CT within one or more sinuses in CIFRS cases. Workers in Brazil in 2002 also found significant associations of bone erosions, microcalcification and mucosal thickness with AFRS cases [1]. Bone erosion was again significantly associated with AFRS in a study done in Chandigarh (India) in 2002-2003 [19].…”

Section: Discussionmentioning

confidence: 98%

“…Classification of FRS depending on the host immune interaction with the fungi and is important for effective treatment and understanding the prognosis of the disease [1]. Disease is most commonly classified as non-invasive or invasive depending on the invasion of the fungi into the sinonasal, submucosal tissue resulting in tissue necrosis and destruction [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Invasive Fungal Rhinosinusitis: An Observational Study in an Indian Tertiary Care Hospital

Kaur¹,

Lavanya²

2016

Lung Dis Treat

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Invasive fungal rhinosinusitis (IFRS) is a challenging condition and the mortality of IFRS in immuno compromised patients is very high. 75 patients of suspected FRS were included to study the burden and the clinicopathological and mycological profile of invasive fungal rhinosinusitis (FRS) in these patients. The samples collected were exudate from nasal debri, discharge and intraoperative tissue sample and were subjected to direct microscopy to histopathological examination and direct microscopy (KOH and calcofluor white) and culture on Sabouraud dextrose agar. Identification of molds and yeasts were done by conventional methods. 25 cases were suspected to have IFRS were confirmed by microbiological and histo pathological examination, comprising 56% of AIFRS (acute IFRS), 36% CIFRS (chronic IFRS) and 8% CGFRS (chronic granulomatous FRS). Rhizopus arrhizus (64.2%) was the most common isolate followed by Aspergillus flavus (35.7%). Mucor species were solely isolated from AIFRS (14.3%). In CIFRS, Aspergillus flavus (44.4%) seemed to be the major isolate with Aspergillus niger, Alternaria spp., Penicillium spp. and Candida albicans. Necrosis of submucosa, bone, vascular tissue was seen in 96% of cases with aseptate hyphae in 78.5% AIFRS and 77.7% in CIFRS. Radiological features help in presumptive diagnosis of FRS. Direct microscopy along with culture conformation is important for diagnosis and early initiation of treatment.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Invasive Fungal Rhinosinusitis: An Observational Study in an Indian Tertiary Care Hospital

Kaur¹,

Lavanya²

2016

Lung Dis Treat

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“…The most common presenting symptoms of AFRS include nasal obstruction, nasal discharge, postnasal drip, cough, problems with smell, sore throat, fatigue and facial pain [10]. As opposed to a CT with a fungal ball, which demonstrates disease within one sinus (typically), patients with AFRS typically have multiple sinuses involved.…”

Section: Figurementioning

confidence: 99%

Role of immunotherapy in allergic fungal rhinosinusitis

Patadia

Welch

2015

Current Opinion in Otolaryngology & Head and Neck Surgery

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“…This increase in incidence may be due to technological advances in mycology, serology, histopathology and radiology. 5,6 Fungal overgrowth in the nose and sinus is enhanced due to the altered normal bacterial flora by increasing use of broad spectrum antibiotic and topical preparations. 7 Besides, in the past two decades there is an increase in the use of immunosuppressant drugs, more cases of diabetes mellitus and human immunodeficiency virus (HIV).…”

Section: Introductionmentioning

confidence: 99%

“…7 Besides, in the past two decades there is an increase in the use of immunosuppressant drugs, more cases of diabetes mellitus and human immunodeficiency virus (HIV). 6 The knowledge of type of fungal flora, its prevalence, supplementary tests in patients with chronic rhinosinusitis (CRS) have enabled a better understanding of the disease and increased the awareness of the involved physicians for appropriate diagnosis and treatment of this disease entity. 6 The fungal agents usually isolated from paranasal sinuses include Aspergillus, Mucor, Histoplasma, Coccidioides, Candida, Fusarium spp, Curvularia spp, Pseudallescheria boydii and Alternaria spp.…”

Section: Introductionmentioning

confidence: 99%

Fungal Rhinosinusitis in Delhi-National Capital Region

Agarwal¹,

Garg²,

Songara³

et al. 2013

An International Journal Clinical Rhinology

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Background and objective: During past decades, fungal rhinosinusitis (FRS) has been diagnosed more frequently. Knowing the fungal flora and its prevalence in chronic rhinosinusitis (CRS) patients will allow a better understanding of this disease, diagnosis and treatment. We studied the prevalence of fungus in CRS patients in Delhi-NCR (National Capital Region) in a tertiary care hospital. Materials and methods:In this prospective study, a total of 180 patients having CRS were enrolled in which functional endoscopic sinus surgery was done. In 173 (96.1%) patients, polyps/tissue/mass were collected during surgery. In seven (3.9%) cases, sinus secretions were obtained. All the collected samples were sent for microbiology and pathology examination. Diagnosis of FRS was confirmed by direct mycological (10% KOH) and/or culture and/or pathology analysis.Results: Forty-eight cases were positive for fungus, out of these 180 patients of CRS. In patients of FRS, the most common presentation was nasal blockage followed by facial pain and facial fullness. The prevalence of FRS was found to be 26.6% in CRS and most common fungal pathogen isolated was Aspergillus flavus.Conclusion: Delhi-NCR region falls under a moderate prevalence area for fungal infection in CRS patients as compared to other regions in India. Majority of cases were isolated in summer months, the dry and hot climate of the Delhi-NCR may be responsible for such prevalence.

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Fungal rhinosinusitis in patients with chronic sinusal disease

Abstract: The symptomatic evolution following endoscopic surgery was more favorable in patients with fungal ball, who require a lower number of re-interventions.

Cited by 22 publications

References 16 publications

Invasive Fungal Rhinosinusitis: An Observational Study in an Indian Tertiary Care Hospital

Invasive Fungal Rhinosinusitis: An Observational Study in an Indian Tertiary Care Hospital

Role of immunotherapy in allergic fungal rhinosinusitis

Fungal Rhinosinusitis in Delhi-National Capital Region

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