Fungal Toxins

Wong, Jack Ho

doi:10.1016/b978-0-12-385095-9.00025-7

Cited by 3 publications

(1 citation statement)

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“…The main groups of fungal RiPPs were isolated from agaricomycetes in the genus Amanita and belong to the amatoxin and phallotoxin families [44]. Amatoxins and phallotoxins are highly toxic compounds exhibiting cyclic octo-and hepta-peptide structures, respectively [45]. Despite the cytotoxicity of these metabolites, amatoxins and phallotoxins have yielded valuable compounds, although admittedly not antibiotics.…”

Section: Ribosomally Synthesised and Post-translationally Modified Pementioning

confidence: 99%

Selected Fungal Natural Products with Antimicrobial Properties

Jakubczyk

Dussart

2020

Molecules

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Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.

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Section: Ribosomally Synthesised and Post-translationally Modified Pementioning

confidence: 99%