Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis

Leonardi, Irina; Paramsothy, Sudarshan; Doron, Itai; Semon, Alexa; Kaakoush, Nadeem O.; Clemente, José C.; Faith, Jeremiah J.; Borody, Thomas J.; Mitchell, Hazel M.; Colombel, Jean–Frédéric; Kamm, Michael A.; Iliev, Iliyan D.

doi:10.1016/j.chom.2020.03.006

Cited by 133 publications

(91 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent data suggest that patients with UC responding to FMT exhibit higher bacterial species richness and Candida abundance at baseline, before FMT. Additionally, 15 specific fecal metabolites at baseline were also associated with FMT efficacy and may constitute predictive markers of efficacy [8,9]. We also reported in CD that FMT failure was associated with baseline enrichment in members of the Gamma-proteobacteria class such as Klebsiella, Actinobacillus, and Haemophilus, in accordance with previous findings in UC [2,8].…”

Section: The Right Donor For the Right Patientsupporting

confidence: 88%

Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine

Benech

Sokol

2020

Genome Med

View full text Add to dashboard Cite

show abstract

Section: The Right Donor For the Right Patientsupporting

confidence: 88%

Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine

Benech

Sokol

2020

Genome Med

View full text Add to dashboard Cite

show abstract

“…Leonardi et al suggested fungal trans-kingdom dynamics may be of importance in FMT outcomes in UC. In particular, they found that pre-FMT Candida associated with bacterial diversity and genera linked to responsiveness and demonstrated a fall in Candida species in responders post FMT [ 36 • ]. With respect to the virome, analyses from a small cohort study of 9 UC patients suggested that while no difference was identified in the phageome, low eukaryotic viral richness associated with FMT success [ 37 • ].…”

Section: Faecal Microbiota Transplantation For the Treatment Of Ulcermentioning

confidence: 99%

The role of faecal microbiota transplantation in the treatment of inflammatory bowel disease

Haifer

Leong

Paramsothy

2020

Current Opinion in Pharmacology

Self Cite

View full text Add to dashboard Cite

Purpose of the review Faecal microbiota transplantation (FMT) has emerged as a potent form of therapeutic microbial manipulation. There is much interest in exploring its potential in conditions such as inflammatory bowel disease (IBD) where disturbances in the gastrointestinal microbiota play a crucial role in disease pathogenesis. Recent findings There are 4 randomized controlled trials of FMT as induction therapy in ulcerative colitis, with meta-analyses suggesting significant benefit over placebo. Allied microbial studies have identified potential microbial and metabolic predictors of therapeutic efficacy and highlighted the importance of optimizing future donor and patient selection. Recent literature has evaluated the use of complementary microbial manipulation through pre-antibiotics to improve treatment efficacy. Studies have also assessed the durability of FMT response and its use in maintenance therapy of UC. While data on FMT are more limited in Crohn’s disease and pouchitis, cohort and pilot randomized controlled data a now also emerging in these areas.

show abstract

“…This strategy works on an organ or tissue "transplant" therapeutic model and recognizes microbiota as a complex unit. FMT reduces Candida by suppressing pro-inflammatory immune responses during intestinal disease [131]. Another study revealed that FMT is effective in preventing Candida colonization of the GI tract [132].…”

Section: Microbiota Transplantmentioning

confidence: 99%

Understanding Human Microbiota Offers Novel and Promising Therapeutic Options against Candida Infections

et al. 2021

View full text Add to dashboard Cite

Human fungal pathogens particularly of Candida species are one of the major causes of hospital acquired infections in immunocompromised patients. The limited arsenal of antifungal drugs to treat Candida infections with concomitant evolution of multidrug resistant strains further complicates the management of these infections. Therefore, deployment of novel strategies to surmount the Candida infections requires immediate attention. The human body is a dynamic ecosystem having microbiota usually involving symbionts that benefit from the host, but in turn may act as commensal organisms or affect positively (mutualism) or negatively (pathogenic) the physiology and nourishment of the host. The composition of human microbiota has garnered a lot of recent attention, and despite the common occurrence of Candida spp. within the microbiota, there is still an incomplete picture of relationships between Candida spp. and other microorganism, as well as how such associations are governed. These relationships could be important to have a more holistic understanding of the human microbiota and its connection to Candida infections. Understanding the mechanisms behind commensalism and pathogenesis is vital for the development of efficient therapeutic strategies for these Candida infections. The concept of host-microbiota crosstalk plays critical roles in human health and microbiota dysbiosis and is responsible for various pathologies. Through this review, we attempted to analyze the types of human microbiota and provide an update on the current understanding in the context of health and Candida infections. The information in this article will help as a resource for development of targeted microbial therapies such as pre-/pro-biotics and microbiota transplant that has gained advantage in recent times over antibiotics and established as novel therapeutic strategy.

show abstract

Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis

Cited by 133 publications

References 34 publications

Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine

Fecal microbiota transplantation in gastrointestinal disorders: time for precision medicine

The role of faecal microbiota transplantation in the treatment of inflammatory bowel disease

Understanding Human Microbiota Offers Novel and Promising Therapeutic Options against Candida Infections

Contact Info

Product

Resources

About