Fungemia by yeasts in Brazil: occurrence and phenotypic study of strains isolated at the Public Hospital, Botucatu, São Paulo

Ruiz, L.S.; Sugizaki, Mário Mateus; Montelli, Augusto Cézar; Matsumoto, Flavia E.; Pires, Marinês Ferreira; Silva, Bosco Christiano Maciel da; Silva, E.H.; Gandra, Rinaldo Ferreira; Silva, E. Gonçalves da; Auler, Marcos Ereno; Paula, Claudete Rodrigues

doi:10.1016/j.mycmed.2004.12.002

Cited by 23 publications

(28 citation statements)

References 34 publications

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“…Candida albicans was the species most frequently found among patients (53.8%), corroborating what other studies have been demonstrating in different anatomical sites 19,30,31,34,35 .…”

Section: Discussionsupporting

confidence: 90%

“…Fifty percent to 60% of the patients who present this species are expected to develop systemic infections 38 . Other studies point to C. parapsilosis as the most prevalent species among the Candida non-albicans [1][2][3][4]18,24,34,35,39 . In pediatric or neonatal units, C. parapsilosis has been marked as the second most common agent in patients with candidemia, a fact that is linked to the exogenous contamination because of the patients' manipulation by the hospital staff, the patients' exposure to invasive procedures in the ICU, prematurity, immunosuppression, and long-course antibiotic therapy 34,35,[39][40][41] .…”

Section: Discussionmentioning

confidence: 99%

“…Other studies point to C. parapsilosis as the most prevalent species among the Candida non-albicans [1][2][3][4]18,24,34,35,39 . In pediatric or neonatal units, C. parapsilosis has been marked as the second most common agent in patients with candidemia, a fact that is linked to the exogenous contamination because of the patients' manipulation by the hospital staff, the patients' exposure to invasive procedures in the ICU, prematurity, immunosuppression, and long-course antibiotic therapy 34,35,[39][40][41] . Results from many other works have evidenced C. tropicalis or C. parapsilosis as the main Candida non-albicans agent involved in the different types of candidemia around us 38,[42][43][44][45][46][47] , which is different from what has been observed in Europe and North America, where C. glabrata has been detected as the second most recurrent pathogen after C. albicans 43,44,[47][48][49] .…”

Section: Discussionmentioning

confidence: 99%

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Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Storti

Pasquale

Scomparim

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: This study aimed to isolate and identify Candida spp. from the environment, health practitioners, and patients with the presumptive diagnosis of candidiasis in the Pediatric Unit at the Universitary Hospital of the Jundiaí Medical College, to verify the production of enzymes regarded as virulence factors, and to determine how susceptible the isolated samples from patients with candidiasis are to antifungal agents. METHODS: Between March and November of 2008 a total of 283 samples were taken randomly from the environment and from the hands of health staff, and samples of all the suspected cases of Candida spp. hospital-acquired infection were collected and selected by the Infection Control Committee. The material was processed and the yeast genus Candida was isolated and identified by physiological, microscopic, and macroscopic attributes. RESULTS: The incidence of Candida spp. in the environment and employees was 19.2%. The most frequent species were C. parapsilosis and C. tropicalis among the workers, C. guilliermondii and C. tropicalis in the air, C. lusitanae on the contact surfaces, and C. tropicalis and C. guilliermondii in the climate control equipment. The college hospital had 320 admissions, of which 13 (4%) presented Candida spp. infections; three of them died, two being victims of a C. tropicalis infection and the remaining one of C. albicans. All the Candida spp. in the isolates evidenced sensitivity to amphotericin B, nystatin, and fluconazole. CONCLUSIONS: The increase in the rate of hospital-acquired infections caused by Candida spp. indicates the need to take larger measures regarding recurrent control of the environment.

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“…Candida albicans was the species most frequently found among patients (53.8%), corroborating what other studies have been demonstrating in different anatomical sites 19,30,31,34,35 .…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Storti

Pasquale

Scomparim

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…These data have been confirmed by statistical studies performed in South America that have shown the relevance of invasive infections due to C. parapsilosis and C. tropicalis 12,13,27,39 . The reasons for this inversion of the species' distribution pattern have not yet been completely elucidated, but may be related to the microorganisms virulence potential and resistance to antifungals 8 .…”

Section: Discussionsupporting

confidence: 63%

Candiduria in a public hospital of São Paulo (1999-2004): characteristics of the yeast isolates

Silva

Ruiz

Matsumoto

et al. 2007

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe study involved 100 yeast isolates, obtained from urine samples provided by a Public Pediatric Hospital of São Paulo, Brazil, from 1999 to 2004. The most frequent species was Candida albicans, followed by C. tropicalis, C. glabrata and C. parapsilosis. In regard to virulence, 97% of the isolates showed index 3 for proteinase and 63% index 2 for phospholipase. The most frequent killer biotypes were 511 and 888.

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“…This rise ranked Candida fourth among the most common bloodstream isolates and nosocomial bloodstream infections, and among the most commonly cultured organisms from all sites in intensive care units (ICUs) in the United States of America (USA) [5][6][7]. Certain risk factors augment the risk of candidemia, including immunosuppression, prolonged use of antibiotics, prolonged stay in ICUs, and use of central venous catheters [8].…”

Section: Introductionmentioning

confidence: 99%

Candida profiles and antifungal resistance evolution over a decade in Lebanon

Araj

Asmar

Avedissian

2015

J Infect Dev Ctries

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Introduction: Infection with and antifungal resistance of Candida species have been on the rise globally. Relevant data on these pathogens are relatively few in our region, including Lebanon, thus warranting this study. Methodology: This retrospective study of Candida spp. profiles and their in vitro antifungal susceptibility was based on analysis requests for 186 Candida non-albicans and 61 C. albicans during three periods (2005-2007, 2009-2011, and 2012-2014) over the span of the last 10 years at the American University of Beirut Medical Center (AUBMC), a major tertiary care center in Lebanon. Identification of Candida was done using the API 20C AUX system, and the E-test was used to determine the minimum inhibitory concentrations (MICs) of antifungal agents. Results: Among the 1,300-1,500 Candida isolates recovered yearly, C. albicans rates decreased from 86% in 2005 to around 60% in 2014. Simultaneously, the non-albicans rates increased from 14% in 2005 to around 40% in 2014, revealing 11 species, the most frequent of which were C. tropicalis, C. glabrata, and C. parapsilosis. All these demonstrated high resistance (35%-79%) against itraconazole, but remained uniformly susceptible (100%) to amphotericin B. Though C. albicans and the other species maintained high susceptibility against fluconazole and voriconazole, their MIC 90 showed an elevated trend over time, and C. glabrata had the highest resistance rates. Conclusions: The observed rise in resistance among Candida spp. in Lebanon mandates the need for close surveillance and monitoring of antifungal drug resistance for both epidemiologic and treatment purposes.

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Fungemia by yeasts in Brazil: occurrence and phenotypic study of strains isolated at the Public Hospital, Botucatu, São Paulo

Cited by 23 publications

References 34 publications

Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Candiduria in a public hospital of São Paulo (1999-2004): characteristics of the yeast isolates

Candida profiles and antifungal resistance evolution over a decade in Lebanon

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