Fungemia due to Kodamaea ohmeri : First isolating in Italy. Case report and review of literature

Distasi, Maria Antonietta; Gaudio, Tito Del; Pellegrino, Giulia Michela; Pirronti, A.; Passera, Marco; Farina, Claudio

doi:10.1016/j.mycmed.2015.08.002

Cited by 10 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among the 35 studies on K ohmeri infections, 30 (85.7%) reported fungemias, accounting for 36 patients out of 44 (81.8%) in total 3,4,7–34 . A concomitant infection was present in 22.2% (8 out of 36 fungemias), namely infective endocarditis (IE) in 11.1% (4 cases), 31–34 skin and soft tissue infection (SSTI) in 5.6% (2 cases), 16,21 disseminated infection with involvement of the spleen, urinary tract and lower respiratory tract in 2.8% (1 case), 8 and lower respiratory tract infection in 2.8% (1 case) 29 .…”

Section: Resultsmentioning

confidence: 99%

Kodamaea ohmeri infections in humans: A systematic review

Ιωάννου

Papakitsou

2020

Mycoses

View full text Add to dashboard Cite

Summary Background Kodamaea ohmeri, previously known as Pichia ohmeri or Yamadazyma ohmeri, belongs to the Saccharomycetaceae family and the Ascomycetae class, is the telomorphic form of C guilliermondii var. membranaefaciens and is frequently mistaken for Candida, as they belong to the same family. It has been isolated from environmental sources, such as sand, pools, seawater and fruits, while the last decades it is recognised as a rare pathogen that causes life‐threatening infections in humans. The purpose of this study was to systemically review all published cases of K ohmeri infections in the literature and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. Methods Systematic review of PubMed (through 27th December 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of K ohmeri infections. Results A total of 35 studies, containing data of 44 patients, were included in the analysis. The most common K ohmeri infections were those of the bloodstream, infective endocarditis and onychomycosis. Previous antibiotic use, presence of a central venous catheter, parenteral nutrition and cancer were very common among patients. Mortality was high in the case of fungemias but low for other types of infections. Amphotericin B and fluconazole are the most common agents used for treatment, even though alarming MICs for fluconazole were noted. Conclusions This systematic review thoroughly describes infections by K ohmeri and provides information on their epidemiology, clinical presentation, microbiology, antibiotic resistance patterns, treatment and outcomes.

show abstract

Section: Resultsmentioning

confidence: 99%

Kodamaea ohmeri infections in humans: A systematic review

Ιωάννου

Papakitsou

2020

Mycoses

View full text Add to dashboard Cite

show abstract

“…Compared to the large cluster from India,26 the present isolates had similar MIC 90s for amphotericin B, itraconazole and posaconazole, while a two-fold increase in MIC 90 was observed for voriconazole and caspofungin, and a four-fold increase for fluconazole. Previous studies concluded that amphotericin B or echinocandin should be considered to be a good antifungal choice for treatment of K. ohmeri infections 8,37. Considering that antifungal treatment should be adjusted according to susceptibility results of the clinical isolates, based on the MIC results of our isolates, all the eight antifungal agents tested except fluconazole, may be successful in treating most of the K. ohmeri infections according to the in vitro susceptibility results.…”

Section: Discussionmentioning

confidence: 99%

<p>Identification and antifungal susceptibility profiles of <em>Kodamaea ohmeri</em> based on a seven-year multicenter surveillance study</p>

Zhou¹,

Yu²,

Kudinha

et al. 2019

IDR

View full text Add to dashboard Cite

Background Kodamaea ohmeri has been a rare fungal pathogen in the past decades but is now becoming more common in various invasive fungal diseases, with high mortality. There are limited data on the occurrence and distribution of K. ohmeri . Methods Sixty-two K. ohmeri isolates collected from 24 hospitals in China over a 7-year period were studied. Performance of three phenotypic methods in the identification of this organism was assessed against a gold standard, 26S rDNA sequencing. Original identification results submitted by the participating local hospitals were reviewed. The Sensititre YeastOne YO10 (SYY) was evaluated in determining the in vitro antifungal susceptibilities using standard broth microdilution method (BMD) as a reference, and essential agreement (EA) was calculated. Results Accurate species identification was achieved in 82.3% and 96.8% of the cases by Vitek 2 Compact and Vitek mass spectrometry (MS), respectively. For Bruker MS, 12.9% and 96.8% of the isolates were correctly identified to species level using the direct transfer and protein extraction methods, respectively. Only 29 (46.8%) isolates were initially correctly identified as K. ohmeri by the local hospitals. The highest misidentification rate (100%, 16/16) was observed in CHROMagar. According to BMD, the highest MIC 90 was seen in fluconazole (8 μg/mL), followed by 1 μg/mL for micafungin, caspofungin, 5-fluorocytosine, and amphotericin B, 0.5 μg/mL for itraconazole, 0.25 μg/mL for posaconazole and voriconazole. Significant differences in EAs for different drugs were observed, ranging from 95.2% for amphotericin B to 22.6% for itraconazole between SYY and BMD. Conclusion Our study emphasizes the need for accurate identification of clinical K. ohmeri isolates and the importance of validating antifungal susceptibility by standard BMD.

show abstract

“…There have been 88 reports of infection with K. ohmeri described in the literature. Among them, 76 patients presented with fungaemia and the remaining presented with peritonitis (three patients), endocarditis (four patients), urinary tract infection (one patient), polymicrobial wound infection (one patient) and oral ulcer (three patients). In the present case, the lesion was exclusively limited to the site of the wound without systemic involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus, malignant tumour, intravenous drug use, cardiac prosthetic valves, chronic kidney diseases and premature infants are risk factors for invasive infections due to K. ohmeri . Some cases of fungaemia resulted from catheter‐related issues, cellulitis or burned skin, suggesting that breakdown of the mucocutaneous barrier is a significant risk factor for systemic K. ohmeri infection. In this case, our patient was at risk of invasive infections because she had rheumatoid arthritis and received oral low‐dose methylprednisolone.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous granuloma caused by Kodamaea ohmeri in an immunocompromised patient in China

Yan

Gao

et al. 2019

Aust J Dermatology

View full text Add to dashboard Cite

We present a case of subcutaneous granuloma caused by Kodamaea ohmeri and describe the histopathological characteristics and skin lesions caused by this pathogen. A 55-year-old woman, with a history of rheumatoid arthritis, presented with red, painless plaque on her forehead, persistent for 3 months; based on the histopathological and mycological findings and gene sequencing, the patient was diagnosed with subcutaneous granuloma caused by K. ohmeri. This report highlights that early identification and diagnosis and optimal regimens are vital in the management of this intractable infection.

show abstract

Fungemia due to Kodamaea ohmeri : First isolating in Italy. Case report and review of literature

Cited by 10 publications

References 29 publications

Kodamaea ohmeri infections in humans: A systematic review

Kodamaea ohmeri infections in humans: A systematic review

<p>Identification and antifungal susceptibility profiles of <em>Kodamaea ohmeri</em> based on a seven-year multicenter surveillance study</p>

Subcutaneous granuloma caused by Kodamaea ohmeri in an immunocompromised patient in China

Contact Info

Product

Resources

About