Fungemia Due to Torulopsis glabrata

Jt, Morris; Ck, McAllister

doi:10.1097/00007611-199303000-00021

Cited by 7 publications

(3 citation statements)

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“…Fungemia has been reported in patients with underlying debilitating conditions and most commonly presents as high fever and hypotension. 1 An increasing incidence of infection is thought to be secondary to aggressive therapy with antibiotics, corticosteroids, and surgical techniques. 2,3 The literature shows a continually broadening spectrum of infectious sites.…”

Section: Discussionmentioning

confidence: 99%

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Torulopsis glabrata fungemia as a complication of a clotted transjugular intrahepatic portosystemic shunt

Darwin¹,

Mergner²,

Thuluvath³

1998

Liver Transpl

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Torulopsis glabrata fungemia developed in a patient with a clotted transjugular intrahepatic portosystemic shunt (TIPS) 11 months after placement. Fungemia persisted despite treatment with amphotericin B. On autopsy, T. glabrata was found in the thrombus occluding the TIPS and extending into the splenic and portal vein. TIPS infections may be considered in patients with fungemia. Copyright 1998 by the American Association for the Study of Liver Diseases T orulopsis glabrata (Candida glabrata) is considered to be a saprophyte of humans and to be of limited pathogenicity. 1 Under conditions of altered resistance, this yeast can become pathogenic. 2 We report a patient with T. glabrata fungemia from a clotted transjugular intrahepatic portosystemic shunt (TIPS) that was seeded with yeast. Case ReportA 55-year-old man with end-stage liver disease secondary to cryptogenic cirrhosis underwent TIPS for recurrent variceal bleeding. Two revisions for stent occlusion were done over the next 6 months while he awaited liver transplantation. He was admitted 11 months after TIPS placement with right upper quadrant pain and fever. Evaluation included a right upper quadrant ultrasound that showed a thick-walled gallbladder with cholelithiasis, no ductal dilatation or TIPS flow, bilirubin of 24 mg/dL (direct 15), and alkaline phosphatase of 43 U/L. Broad-spectrum antibiotic therapy was begun, and the patient underwent endoscopic retrograde cholangiopancreatography that showed no common duct stones. Blood cultures drawn 7 days after admission grew T. glabrata. Amphotericin B was started, and the patient underwent cholecystectomy.Complications during hospitalization included a perioperative myocardial infarction and renal failure. Despite 26 days of amphotericin therapy (total, 1,950 mg) and additional flucytosine, multiple blood cultures remained positive for T. glabrata. A transthoracic cardiac echo showed no vegetations. The patient was transferred to our hospital and died on day 27 after the initial admission. On autopsy, T. glabrata was found in thrombus that occluded the TIPS and extended into the splenic and portal vein with no other sites of infection or thrombus found.

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Section: Discussionmentioning

confidence: 99%

“…T orulopsis glabrata (Candida glabrata) is considered to be a saprophyte of humans and to be of limited pathogenicity. 1 Under conditions of altered resistance, this yeast can become pathogenic. 2 We report a patient with T. glabrata fungemia from a clotted transjugular intrahepatic portosystemic shunt (TIPS) that was seeded with yeast.…”

mentioning

confidence: 99%

Torulopsis glabrata fungemia as a complication of a clotted transjugular intrahepatic portosystemic shunt

Darwin¹,

Mergner²,

Thuluvath³

1998

Liver Transpl

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“…We have investigated the surface chemistry of intact cells from Candida glabrata and three Saccharomyces cerevisiae strains, the two haploid strains BY4741 and BY4742 and the diploid strain BY4743, using a primary Au + ion beam. C. glabrata is a common saprophyte in humans, which may become pathogenic in immunocompromised patients, , while S. cerevisiae is probably the best characterized eukaryotic organism and has been used by mankind for millennia in the production of bread, beer, and wine.…”

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confidence: 99%

Application of TOF-SIMS with Chemometrics To Discriminate between Four Different Yeast Strains from the Species Candida glabrata and Saccharomyces cerevisiae

et al. 2005

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We present a TOF-SIMS analysis of the cell surface differences between four yeast strains from two species, Candida glabrata and Saccharomyces cerevisiae (haploid strains BY4742 and BY4741 and the derived diploid BY4743). The study assesses the suitability of TOF-SIMS analysis in combination with statistical methods (principal component analysis, Fisher's discriminant analysis, and cluster analysis) for the discrimination between the four yeast strains. We demonstrate that a combination of these statistical methods identifies 34 ions, from a total data set of 1200, which can be used to distinguish between the four yeasts. The study discusses the assignments of surface cell membrane phospholipids for the identified ions and the resulting differences in the phospholipid pattern between the four yeasts, particularly in relation to ploidy and budding pattern. The method shows that fatty acids, phosphatidylglycerols, phosphatidylethanolamines, phosphatidylserines, and phosphatidylcholines, as well as cardiolipins, are of diagnostic importance.

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Torulopsis

Hommel¹,

Kleber²

1999

Encyclopedia of Food Microbiology

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Fungemia Due to Torulopsis glabrata

Cited by 7 publications

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Torulopsis glabrata fungemia as a complication of a clotted transjugular intrahepatic portosystemic shunt

Torulopsis glabrata fungemia as a complication of a clotted transjugular intrahepatic portosystemic shunt

Application of TOF-SIMS with Chemometrics To Discriminate between Four Different Yeast Strains from the Species Candida glabrata and Saccharomyces cerevisiae

Torulopsis

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