FUNGICIDAL ACTION OF CAPRYLIC ACID FOR <i>CANDIDA ALBICANS</i>

Tsukahara, Tohru

doi:10.1111/j.1348-0421.1961.tb00217.x

Cited by 4 publications

(4 citation statements)

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“…C. albicans appears to be uniquely sensitive to fatty acids with carbon chain lengths of C 8 , C 10 , and C 12 , represented by caprylic, capric, and lauric acid, respectively (47). As early as the 1960s, Tsukahara demonstrated that caprylic acid was a robust, fast-acting fungicide (48). Treatment of C. albicans with caprylic acid at even relatively low concentrations (e.g., 10 Ϫ5 M) led to total killing in as little as 10 min of contact time.…”

Section: Discussionmentioning

confidence: 99%

Disparate Candida albicans Biofilm Formation in Clinical Lipid Emulsions Due to Capric Acid-Mediated Inhibition

Willems

Stultz

Coltrane

et al. 2019

Antimicrob Agents Chemother

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Receipt of parenteral nutrition (PN) remains an independent risk factor for developing catheter-related bloodstream infections (CR-BSI) caused by fungi, including by the polymorphic fungus Candida albicans, which is notoriously adept at forming drug-resistant biofilm structures. Among a variety of macronutrients, PN solutions contain lipid emulsions to supply daily essential fats and are often delivered via central venous catheters (CVCs). Therefore, using an in vitro biofilm model system, we sought to determine whether various clinical lipid emulsions differentially impacted biofilm growth in C. albicans. We observed that the lipid emulsions Intralipid and Omegaven both stimulated C. albicans biofilm formation during growth in minimal medium or a macronutrient PN solution. Conversely, Smoflipid inhibited C. albicans biofilm formation by approximately 50%. Follow-up studies revealed that while Smoflipid did not impair C. albicans growth, it did significantly inhibit hypha formation and hyphal elongation. Moreover, growth inhibition could be recapitulated in Intralipid when supplemented with capric acid—a fatty acid present in Smoflipid but absent in Intralipid. Capric acid was also found to dose dependently inhibit C. albicans biofilm formation in PN solutions. This is the first study to directly compare different clinical lipid emulsions for their capacity to affect C. albicans biofilm growth. Results derived from this study necessitate further research regarding different lipid emulsions and rates of fungus-associated CR-BSIs.

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Section: Discussionmentioning

confidence: 99%

Disparate Candida albicans Biofilm Formation in Clinical Lipid Emulsions Due to Capric Acid-Mediated Inhibition

Willems

Stultz

Coltrane

et al. 2019

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…Therefore, it is considered that caprylic acid may be capable of permeating through the cell membrane promptly and may bind with enzyme proteins of the cells stably and irreversibly, thus destroying their activity in a moment. In the previous report (Tsukahara, 1961) (1), it was pointed out that the fungicidal activity of caprylic acid was more intensive in an acid environment at pH levels below 6.24. This fact strongly suggests that the acid may react upon the basic group of protein molecules impartially.…”

Section: Discussionmentioning

confidence: 95%

“…The same organism, culture medium and caprylic aid, as described in the previous paper (Tsukahara, 1961…”

Section: Methodsmentioning

confidence: 99%

“…

The first report of this series (Tsukahara, 1961)(1) was concerned with the fungicidal action of caprylic acid, having eight carbon atoms in its chain, on Candida albicans and the effect of some physical and chemical agents upon the action. A quantitative and biochemical observation of the fungicidal action was described.In the present paper, the possible mechanisms of the action will be described.

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confidence: 99%

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