Fungicidal Effect of Antimicrobial Peptide, PMAP-23, Isolated from Porcine Myeloid against Candida albicans

Lee, Dong Gun; Kim, Dae–Hee; Park, Yoonkyung; Kim, Hyung Keun; Kim, Heung Dong; Shin, Yong Kook; Choi, Choong Hyeok; Hahm, Kyung‐Soo

doi:10.1006/bbrc.2001.4602

Cited by 43 publications

(30 citation statements)

References 26 publications

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“…The sequence is highly cationic with five arginines and two lysines. Synthesized peptide displays remarkable in vitro antimicrobial activity against Gram-negative bacteria [41], Gram-positive bacteria [41], yeasts [42] and moulds [42]. MICs range from 2 Á/16 mM [40,41].…”

Section: Cationic Antimicrobial Peptidesmentioning

confidence: 99%

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Antimicrobial peptides in animals and their role in host defences

Brogden

Ackermann

McCray

et al. 2003

International Journal of Antimicrobial Agents

418

287

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Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. These peptides differ in size, composition, mechanisms of activity and range of antimicrobial specificities. They are expressed in many tissues, polymorphonuclear leukocytes, macrophages and mucosal epithelial cells. There is a small group of anionic antimicrobial peptides found in ruminants and a much larger group of cationic antimicrobial peptides found in all domesticated animals. The cationic peptides include linear, helical peptides, linear peptides rich in proline and cysteine-stabilized peptides with a b-sheet and are commonly referred to as cathelicidins and defensins. These peptides are generally broad-spectrum for Gram-positive bacteria, Gram-negative bacteria and fungi (e.g. myeloid antimicrobial peptides, a-, bdefensins, and protegrins) or are specific to one of these groups (e.g. porcine cecropin P1, Bac5, Bac7, PR-39 and prophenin). RightsWorks produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted. Abstract Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. These peptides differ in size, composition, mechanisms of activity and range of antimicrobial specificities. They are expressed in many tissues, polymorphonuclear leukocytes, macrophages and mucosal epithelial cells. There is a small group of anionic antimicrobial peptides found in ruminants and a much larger group of cationic antimicrobial peptides found in all domesticated animals. The cationic peptides include linear, helical peptides, linear peptides rich in proline and cysteine-stabilized peptides with a b-sheet and are commonly referred to as cathelicidins and defensins. These peptides are generally broad-spectrum for Gram-positive bacteria, Gram-negative bacteria and fungi (e.g. myeloid antimicrobial peptides, a-, b-defensins, and protegrins) or are specific to one of these groups (e.g. porcine cecropin P1, Bac5, Bac7, PR-39 and prophenin). Published by Elsevier B.V.

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Section: Cationic Antimicrobial Peptidesmentioning

confidence: 99%

“…MICs range from 2 Á/16 mM [40,41]. Antibacterial [41] and antifungal activities [42] appear to be at the plasma membrane. The peptide can also prevent the regeneration of fungal cell walls.…”

Section: Cationic Antimicrobial Peptidesmentioning

confidence: 99%

Antimicrobial peptides in animals and their role in host defences

Brogden

Ackermann

McCray

et al. 2003

International Journal of Antimicrobial Agents

418

287

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“…Killing occurs on contact in low-or no-salt concentrations. One such candidacidal peptide is PMAP-23, derived from porcine myeloid cells (12). This is a 23-mer peptide with several wellcharacterized derivatives that is broadly microbicidal (14).…”

mentioning

confidence: 99%

Inhibition of Adherence and Killing of Candida albicans with a 23-Mer Peptide (Fn/23) with Dual Antifungal Properties

Klotz

Gaur²,

Rauceo

et al. 2004

Antimicrob Agents Chemother

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“…Recent physiological and biochemical research has shown that the protein in food not only furnishes amino acids but also provides bioactive peptides after digestion or food processing [114]. Consequently, bioactive peptides produced from both animal and plant sources are now being widely investigated and have been reported to have antibacterial [115,116], opioid [117], antitumor [118], antioxidant [119,120], and angiotensin I-converting enzyme (ACE) inhibitory (anti-hypertensive) [121,122] activities. Bioactive peptides derived from food proteins are considered milder and safer than synthetic drugs and are easily absorbed [123].…”

Section: Bioactive Compoundsmentioning

confidence: 99%