Fungicidal potential of selected plant extracts against human pathogenic fungi

Hassan, Zurina; Tijani, Yahaya; Shettima, Abubakar; Modu, Babagana; Damasak, Abdullahi Ali; Uzairu, Sani Muhammad

doi:10.1016/j.sciaf.2021.e00864

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…To measure zones of inhibition, the punch well method was used (Zanna et al, 2021). The 20 ml of nutritional agar was dispensed into sterilized Petri plates, and the plates were then left to set.…”

Section: Antifungal Activity Assaymentioning

confidence: 99%

Evaluation of Boerhavia diffusa and Eichhornia crassipes plant extracts in vitro as potential antifungal agents against human pathogenic fungi Candida albician and Candida tropicalis : A comparative study

Kumar,

Singh,

Mukherjee

et al. 2023

JANS

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Plant extracts are used to make herbal remedies with no side effects and little expense. During the COVID-19 pandemic, fungal species responsible for mucormycosis were found resistant to a variety of antifungals, including flucytosine, ketoconazole, fluconazole, voriconazole, itraconazole and echinocandins, due to their variable susceptibility. Amphotericin B is widely used as an antifungal agent due to its high inhibition capacity against various fungi. The present study aimed to compare the antifungal potential of Amphotericin B and herbal extract in vitro. The experiment was designed to measure zones of inhibition with the help of well-diffusion method. Four solvents, viz. methanol, chloroform, hexane and distilled water, were used to extract plant extract. The efficiency of plant extracts was found to be low compared to Amphotericin B (1.4mm). Chloroform extract of Boerhavia diffusa was found antifungal against Candida albician and C. tropicalis (0.45mm). Methanol and hexane extract of Eichhornia crassipes showed higher antifungal activity (1.35mm) and (1.75mm), respectively. The plant extracts also showed significant antifungal activity against C. tropicalis, revealing its potential to be used as a natural antifungal agent (1.1mm). Additionally, the findings showed that the chloroform and methanol extracts of B. diffusa and E. crassipes were also efficient against C. albician and C. tropicalis. The findings provide important insights about using plant extracts as a potential alternative to conventional antifungal agents.

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Section: Antifungal Activity Assaymentioning

confidence: 99%

Evaluation of Boerhavia diffusa and Eichhornia crassipes plant extracts in vitro as potential antifungal agents against human pathogenic fungi Candida albician and Candida tropicalis : A comparative study

Kumar,

Singh,

Mukherjee

et al. 2023

JANS

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show abstract

“…After drying, the sliced leaves attained pulverization using a blender. The powder then sustained maceration with methanol PA (proanalysis) and n-hexane for 72 h to extract the bioactive compounds found in the plant's leaves, following the protocols from Zana et al (2021). Meanwhile, the succeeding steps used…”

Section: Plant Collection and Leaf Extractionmentioning

confidence: 99%

Assessment of Plants’ Leaf Extracts for Antifungal Activity Against the Fungus Colletotrichum Acutatum in Chili (Capsicum Annuum L.)

SUDIRGA

2023

SABRAOJBG

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In horticultural crops, including chili, the wide use of synthetic fungicides has manifested to control anthracnose disease; however, these chemicals have some side effects to deal with. In reducing the dependency on synthetic fungicides, other alternatives and means need searching to prevent pathogenic fungi. Therefore, the presented study sought to examine plant extracts with the potential to inhibit the growth of pathogenic fungi Colletotrichum acutatum, the causal organism of anthracnose disease in chili. This study collected 20 potential plant species for the investigation. The leaf extraction used the maceration method in methanol and n-hexane. The contents of chemical compounds sustained the GC-MS analysis. All the leaf extracts tested for their bioactivity underwent the colony method and diffusion well. The results revealed that out of 20 types of plants, six plant species were capable of inhibiting the growth of C. acutatum fungi, including Piper nigrum, Piper ornatum, Piper retrofractum, Ficus septica, Samanea saman, and Tithonia diversifolia. The leaf extract of F. septica has the highest inhibition rate (81.11%) for the growth of C. acutatum compared with other plant leaf extracts. The GC-MS analysis of the F. septica leaf extract showed the presence of 15 types of metabolite constituents, with nine having antimicrobial activities.

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“…According to a study by Zanna et al (2021), different plant extracts have demonstrated efficient in vitro antifungal activities against common spoilage fungi. Moreover, using plant biomolecules as active bioprotective agents against rot fungal pathogens in potatoes has been recently recommended (Steglinska et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Citrus Limon Leaf Extracts against Fungal Pathogens Isolated from Decaying Potato Tubers in Supermarkets of the Eastern Cape Province, South Africa

Ehiobu

2023

Plant Prot.

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Globally, fungal pathogens pose severe threats to stored cereal and tuber crops, resulting in substantial losses in economic crops. This study investigated the inhibitory activities of aqueous, ethanol, and acetone leaf extracts of Citrus limon L. Osbeck against the mycelial growth of Curvularia mebaldsii, Fusarium oxysporum, and Penicillium species isolated from spoilt potato tubers retailed within supermarkets in Eastern Cape Province, South Africa. Various concentrations (100 g/L, 50 g/L, and 25 g/L) of the C. limon leaf extracts (aqueous, acetone and ethanol) were prepared and (5 mL) amended with potato dextrose agar (oxoid, UK) previously inoculated with the 7-day old culture of each fungal isolates before incubation at 28 oC. The percentage growth inhibition was determined to evaluate the antifungal efficacy of each extract. Aqueous, ethanol and acetone extracts at 50g/L and 100 g/L displayed 100 % inhibition against all three pathogens except Penicillium sp. with 91.0 - 90.97 % inhibition. The ethanol and acetone extracts had the most inhibitory effects against F. oxysporum C. mebaldsii. In contrast, the aqueous extracts displayed the least effects, though not significantly different (p0.05) across the concentrations. The notable antifungal effects against F. oxysporum, a prominent pathogen of post-harvest spoilage of potatoes, suggest the potential use of C. limon extracts to enhance the shelf-life of potatoes in supermarkets, specifically, and for post-harvest storage in general.

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Fungicidal potential of selected plant extracts against human pathogenic fungi

Cited by 10 publications

References 14 publications

Evaluation of Boerhavia diffusa and Eichhornia crassipes plant extracts in vitro as potential antifungal agents against human pathogenic fungi Candida albician and Candida tropicalis : A comparative study

Evaluation of Boerhavia diffusa and Eichhornia crassipes plant extracts in vitro as potential antifungal agents against human pathogenic fungi Candida albician and Candida tropicalis : A comparative study

Assessment of Plants’ Leaf Extracts for Antifungal Activity Against the Fungus Colletotrichum Acutatum in Chili (Capsicum Annuum L.)

Antifungal Activity of Citrus Limon Leaf Extracts against Fungal Pathogens Isolated from Decaying Potato Tubers in Supermarkets of the Eastern Cape Province, South Africa

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