The effect of fungicides and their combination on yield of barley under different nitrogen, slurry and tillage treatments was investigated at Hohenschulen Experimental Station near Kiel, Germany in 1991–97. Various fungicide treatments (no fungicide, and treatment with stem, leaf and ear fungicides and combinations of these), two nitrogen levels (120 and 240 kg N ha−1), two tillage systems (minimum and conventional tillage) and four slurry applications (no application, and autumn, spring and autumn plus spring applications) were used. On average, fungicide application increased barley yield by 1.1 t ha−1. The fungicide treatments could be classified into four types: (1) fungicides against stem diseases, which slightly increased yield by 0.25 t ha−1, very similar to the results for the untreated control; (2) leaf fungicides and ear fungicides applied separately, and fungicides against a combination of stem and leaf diseases, which increased yield by 1.0 t ha−1 on average; (3) fungicides against a combination of ear and stem diseases, which increased the yield by 1.22 t ha−1, and (4) fungicides against a combination of leaf and ear diseases and a combination of stem, leaf and ear diseases, which increased yield by 1.59 t ha−1 on average. The effects of fungicide on the yield were modified by crop husbandry. It can be concluded that application of fungicides against a combination of leaf and ear diseases could increase barley yield and reduce yield variation.