Funktionale Beziehungen zwischen den pharmakokinetischen Eigenschaften und der Dosierung von Chemotherapeutica

Estimation of kinetic parameters from a two‐point determination of the drug cumulation factor

“…1H This term also relates the amount of the drug in the body during continuous intravenous infusion to a single dose. 2,9,11 It has also been called the accumulation ratio,13 Using the relative dosing interval, E, the drug amount ratio may be written as 2 • 9. 11.…”

Multiple Dose Excretion Kinetics

“…(6), had earlier used a simplified form of this equation to obtain the expected maximum and minimum blood levels after intravenous administration. For the dosage regimen of an initial large dose and subsequent smaller equal doses at equal time intervals Swintosky,et al (7), have given an approximation for the fnaximum and minimum blood levels expected, and 9) has derived the equation giving the ratio of initial to sustaining doses such that the blood level at the time of the first sustaining dose will be maintained.…”

Zur Bestimmung des Eiweissadsorptionsfaktors von Chemotherapeutika für Dosierungsberechnungen

“…Die Minimal konzentration cm in ist das Produkt aus der in vitro bestimmten mini malen Hemmkonzentration / x und dem Therapiesicherheitsfaktor er [16][17][18]:…”