Furan-induced cardiotoxicity in diabetic rats and protective role of lycopene

Abstract

The objective of this current study is to search the impacts of furan and lycopene on a diabetic rat's heart. Diabetes increases prevalence with a sedentary lifestyle and obesity. Furan, a carcinogen, was detected in foods that had undergone thermal treatment. Two groups were formed, such as: the control and diabetic groups. Diabetic groups fall into four allocated groups: control, lycopene, furan, and furan + lycopene. The changes in malondialdehide levels, antioxidant enzymes’ activities, and histopathology of the heart were pointed out. We observed that the changes in both the MDA level and the antioxidant enzymes’ activities were due to diabetes. Furan‐induced increment in MDA levels, but GST, CAT, SOD, and GPx activities showed a decrease. Lycopene influenced these changes positively. In terms of the pathological studies, changes were also observed in diabetic rats. The histological damage in the diabetic furan groups was found to be very serious. Lycopene was protective against furan that caused histopathological changes. Diabetes and furan resulted into heart damages in rats and lycopene showed preventive effects. But this was not a complete protection. Practical applications Furan by product of chlorinated chemical compounds production and chemical processes including combustion, are virtually ubiquitous in the environment. Because of this, furan occur potential risk for human health. Furan is known to exist at higher levels in fatty foods, such as full‐fat milk and dairy products, meat and eggs. They can accumulate in the fatty tissues of animals and humans. Diabetes increase in the prevalence of a sedentary lifestyle and obesity. Diabetes with furan‐induced cardiotoxicity. Foods should not be heated over and over again, especially diabetic heart patients should stay away from this situation.

Beneficial Effect of Lycopene on Diabetes Mellitus and its Possible Mechanism: A Review

“…Oxidative stress in the aorta can cause endothelial dysfunction, an initiator and contributing factor to cardiovascular complications of diabetes. 16 Decreased MDA and increased SOD by lycopene treatment, as shown by Zhu et al, are also consistent with many other studies 18,24,25,30,[32][33][34][35][36][37][38][39][40] . A similar study conducted on patients with diabetes showed that lycopene supplementation (4 mg once daily for 3 months) can reduce oxidative stress, as seen from a decrease in MDA and xanthine oxidase levels and an increase in antioxidants such as SOD, GSH, GPx, and GR.…”

Cytoarchitecture changes of the rat thyroid gland following Furan administration implemented Fas-apoptotic pathway with potential abrogating role of selenium

“…Following oral exposure, furan easily permeated through biological membranes, and is rapidly absorbed from the gastrointestinal tract, and metabolized mainly by the liver [9]. Furan was reported to induce injury of many organs and tissues in rodents including; the liver [10], brain [11], kidney [12], and heart [13]. Also, furan was considered by National Toxicology Program (NTP) [14] and International Agency for Research on Cancer (IARC) [15] as "a possibly carcinogenic to humans".…”

A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review

“…Diabetes mellitus (DM) is a metabolic disorder, defined as abnormally elevated blood glucose, resulting from insufficient insulin secretion or insulin resistance in diabetic patients 1 . Chronic hyperglycaemia in diabetic patients can cause severe damage to various cells and organs, such as the retina, heart, kidney, and blood vessels 2 . Recent studies have demonstrated that the prevalence of diabetes mellitus has increased from 451 million people in 2017 and is estimated to reach 693 million by 2045 3 .…”

“…Most of the patients (more than 90%) with elevated blood glucose levels are diagnosed with type 2 DM (T2DM), which is pathologically insulin‐independent 4 . T2DM is characterized by the resistance of hepatocytes, adipocytes, and myocytes to insulin, resulting in progressive cell dysfunction and hyperglycaemia 2 . Previous studies have shown that hyperglycaemia increases the production of free radicals, and oxidative stress 5,6 …”