Furanodiene: A Novel, Potent, and Multitarget Cancer-fighting Terpenoid

Batool, Rabia; Rasul, Azhar; Hussain, Ghulam; Shah, Muhammad Ajmal; Nageen, Bushra; Sarfraz, Iqra; Zahoor, Muhammad Kashif; Riaz, Ammara; Ajaz, Aiza; Adem, Şevki

doi:10.2174/1381612827666210211125304

Cited by 6 publications

(2 citation statements)

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“…In addition, sesquiterpenoids in Curcumae Rhizoma, including zedoarondiol (18), furanodiene (139), and δ-elemene (213), have cytotoxic activity against leukemia cells [95][96][97]. Furthermore, certain compounds, including curcumol (55), germacrone (116), furanodiene (139), and β-elemene (211), have been found to exhibit broad-spectrum cancer-related activity through various pathways [80,[98][99][100][101].…”

Section: Cancer-related Activitymentioning

confidence: 99%

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

Cui,

Li,

Liu

et al. 2024

Biomolecules

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Curcumae Rhizoma, a traditional Chinese medicine with a wide range of pharmacological activities, is obtained from the dried rhizomes of Curcuma phaeocaulis VaL., Curcuma kwangsiensis S. G. Lee et C. F. Liang, and Curcuma wenyujin Y. H. Chen et C. Ling. Sesquiterpenoids and curcuminoids are found to be the main constituents of Curcumae Rhizoma. Sesquiterpenoids are composed of three isoprene units and are susceptible to complex transformations, such as cyclization, rearrangement, and oxidation. They are the most structurally diverse class of plant-based natural products with a wide range of biological activities and are widely found in nature. In recent years, scholars have conducted abundant studies on the structures and pharmacological properties of components of Curcumae Rhizoma. This article elucidates the chemical structures, medicinal properties, and biological properties of the sesquiterpenoids (a total of 274 compounds) isolated from Curcumae Rhizoma. We summarized extraction and isolation methods for sesquiterpenoids, established a chemical component library of sesquiterpenoids in Curcumae Rhizoma, and analyzed structural variances among sesquiterpenoids sourced from Curcumae Rhizoma of diverse botanical origins. Furthermore, our investigation reveals a diverse array of sesquiterpenoid types, encompassing guaiane-type, germacrane-type, eudesmane-type, elemane-type, cadinane-type, carane-type, bisabolane-type, humulane-type, and other types, emphasizing the relationship between structural diversity and activity. We hope to provide a valuable reference for further research and exploitation and pave the way for the development of new drugs derived from medicinal plants.

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Section: Cancer-related Activitymentioning

confidence: 99%

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

Cui,

Li,

Liu

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

“…1,2 For instance, b-elemene, curcumol, curcumenol, furanodiene and furanodienone have already proved to be important components exhibiting anti-cancer bioactivities. [3][4][5][6] In addition, diarylheptanoids, alkaloids, polysaccharides and some other types of compounds are also found in Curcumae radix. 2 Most of the isolated compounds of Curcumae radix have been found in C. wenyujin and C. longa.…”

Section: Introductionmentioning

confidence: 99%