Furanones

Nys, R. de; Givskov, M.; Kumar, N.; Kjelleberg, S.; Steinberg, P.D.

doi:10.1007/3-5403-0016-3_2

Cited by 6 publications

(6 citation statements)

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“…Consequently, GTN could inhibit the binding of these autoinducers to their receptors resulting in quorum sensing inhibition. GTN showed higher quorum sensing inhibiting activity than the classical quorum sensing inhibition C30 furanone 29 as competitive inhibitors of 3-oxo-C12-HSL as shown by lower docking score of GTN than that of C30 furanone.…”

Section: Discussionmentioning

confidence: 93%

Glyceryl trinitrate is a novel inhibitor of quorum sensing in <i>Pseudomonas aeruginosa</i>

Abbas

Shaldam

2017

Afr H. Sci.

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Background: Targeting quorum sensing is an alternative approach to antibiotics.Targeting quorum sensing-regulated virulence will disarm the pathogen without exerting pressure on its growth. As a result, emergence of resistance is avoided and the immune system can easily eradicate bacteria. Objectives: Investigation of the possible inhibition of quorum sensing-regulated virulence of Pseudomonas aeruginosa by glyceryltrinitrate. Methods: The quorum sensing inhibiting activity of glyceryl trinitrate was assessed by inhibition of violacein production in Chromobacterium violaceum ATCC 12472. Its ability to inhibit pyocyanin, protease, biofilm and tolerance to oxidative stress was evaluated. Docking study was performed to study the interference of glyceryl trinitrate with the binding of autoinducers with LasR and rhlR receptors. Results: Glyceryl trinitrate exerted a significant biofilm inhibiting and eradicating activities. It decreased the production of quorum-sensing dependent violacein production. It significantly inhibited the production of pyocyanin and protease and diminished the tolerance against oxidative stress. Molecular docking study showed that glyceryl trinitrate interferes with the binding of autoinducers to their receptors. It could bind to Las Rand rhlr receptors with binding energy of -93.47 and -77.23, respectively. Conclusion: Glyceryl trinitrate can be an antivirulence agent in the treatment of Pseudomonas aeruginosa topical infections such as burn infections.

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Section: Discussionmentioning

confidence: 93%

Glyceryl trinitrate is a novel inhibitor of quorum sensing in <i>Pseudomonas aeruginosa</i>

Abbas

Shaldam

2017

Afr H. Sci.

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“…Furanones are secondary metabolites produced by plants, the most famous being the red alga Delisea pulchra , and delivered to the surface to regulate bacterial colonization . For this reason, in the last two decades, furanones have been under investigation as inhibitors of bacterial colonization.…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Antifouling and antimicrobial biomaterials: an overview

Francolini

Vuotto

Piozzi

et al. 2017

APMIS

264

220

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The use of implantable medical devices is a common and indispensable part of medical care for both diagnostic and therapeutic purposes. However, as side effect, the implant of medical devices quite often leads to the occurrence of difficult‐to‐treat infections, as a consequence of the colonization of their abiotic surfaces by biofilm‐growing microorganisms increasingly resistant to antimicrobial therapies. A promising strategy to combat device‐related infections is based on anti‐infective biomaterials that either repel microbes, so they cannot attach to the device surfaces, or kill them in the surrounding areas. In general, such biomaterials are characterized by antifouling coatings, exhibiting low adhesion or even repellent properties towards microorganisms, or antimicrobial coatings, able to kill microbes approaching the surface. In this light, the present overview will address the development in the last two decades of antifouling and antimicrobial biomaterials designed to potentially limit the initial stages of microbial adhesion, as well as the microbial growth and biofilm formation on medical device surfaces.

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“…Poly(ethylene‐co‐vinyl acetate) copolymer (EVA) films containing essential oil components such as citronellol, eugenol, and linalool have been shown to reduce the mono‐ and dual‐species biofilms of L. monocytogenes , Staphylococcus aureus , Staphylococcus epidermidis , E. coli , and P. aeruginosa (Nostro and others ). Furanones isolated from the marine alga Delisea pulchra have also been extensively studied as QS inhibitors (de Nys and others ; Janssens and others ). Dispersal‐promoting agents (DPAs) such as polysaccharide depolymerases, esterases, dispersin B, proteases, nucleases, chitinase, and DNase can disrupt the EPS and subsequently control mixed‐species biofilms (Xavier and others ; McDougald and others ).…”

Section: Novel Concepts For the Control Of Mixed‐species Biofilmsmentioning

confidence: 99%

The Paradox of Mixed‐Species Biofilms in the Context of Food Safety

Jahid

2014

Comp Rev Food Sci Food Safe

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Formation of mixed-species biofilms constitutes a common adaptation of foodborne pathogens and indigenous microbiota for prolonged survival in their food niche. Nevertheless, the potential role of mixed-species biofilms in food safety remains to be elucidated. The formation of mixed-species biofilms on food and food processing surfaces depends on various physical, chemical, and biological processes including species composition, especially of the indigenous microbiota and nutrients, food types, temperature, quorum sensing, extracellular polymeric substance (EPS) production, biofilms maturation, and dispersal steps. Compared to monospecies, mixed-species are highly resistant to antimicrobials, possibly due to higher EPS production, internalization into food, fitness of species, denser and thicker biofilms maturation, and interspecific protection of 1 species by others, although there are much debate among studies. The fitness of mixed-species biofilms populations is suggested to be of a cooperative, competitive, or neutral nature based on the genetic background of the involved species. Currently, various methods using microarray, confocal microscopy, proteomics, and selective media are being explored for the detection of mixed-species biofilms to resolve the conflict issues. Here, we review recent progress in this emerging field in the context of food safety and propose that novel and alternative techniques like antiquorum sensing, antibiofilms, enzymes, hurdle techniques, and bacteriophages will significantly help to control the formation of mixed-species biofilms for enhanced food safety. The next challenge will be to integrate the fitness and resistance patterns of mixed-species biofilms in the laboratory with those of natural settings.

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Furanones

Cited by 6 publications

References 0 publications

Glyceryl trinitrate is a novel inhibitor of quorum sensing in <i>Pseudomonas aeruginosa</i>

Glyceryl trinitrate is a novel inhibitor of quorum sensing in <i>Pseudomonas aeruginosa</i>

Antifouling and antimicrobial biomaterials: an overview

The Paradox of Mixed‐Species Biofilms in the Context of Food Safety

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