Furazan bis-ureas: a heterocyclic scaffold for anion binding and transport

Abstract

A five-membered central scaffold was used to develop a series of anion receptors. The library perturbed liposomal pH gradients through H+/Cl− transmembrane transport and elicited a variety of cytotoxicities against normal and cancerous cell lines.

N,N′-Dimethylsquaramide as a central scaffold for anionophore design

“…Dual hydrogen bonding scaffolds often participate in intramolecular hydrogen bonding, resulting in preorganised conformations less suited for anion binding. 4,5…”

“…4 Researchers have employed various donor motifs to create a pre-organised cavity and altered the central structure to tune the bite-angle and anion binding affinity. 5 This central group can provide additional hydrogen bond donors to the binding site or possess complementary properties, such as fluorescence. 6…”