Furin-responsive triterpenine-based liposomal complex enhances anticervical cancer therapy through size modulation

Chen, Yunyan; Guo, Mengfei; Qu, Ding; Liu, Yuping; Guo, Jian; Chen, Yan

doi:10.1080/10717544.2020.1827086

Cited by 15 publications

(26 citation statements)

References 79 publications

(124 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, <1%ID/g accumulation of 125 I-SAHA was found in the tumor ( Figure 4(C) ). These results demonstrated that RIP could significantly increase the tumor uptake of SAHA, likely via the enhanced permeation retention effect (Chen et al., 2020 ; Zu et al., 2020 ). After scanning of micro SPECT, organs and tissues were harvested and radioactivity was measured by a gamma counter.…”

Section: Resultsmentioning

confidence: 83%

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Zhu

Sun

et al. 2021

Drug Delivery

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 83%

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Zhu

Sun

et al. 2021

Drug Delivery

View full text Add to dashboard Cite

“…Moreover, an absorbance peak at 785 nm and strong fluorescent signals at 820 nm were observed in the ICG-labeled c(RGDyK)-HAase-IONP (Figure c,d). As shown in Figure e, the particle hydrodynamic size of the highly efficient tumor-targeted nanocarrier c(RGDyK)-HAase-IONP was 19.9 ± 3.9 nm, while it increased to 26.6 ± 4.7 nm after DOX was loaded, which was suitable for in vivo drug delivery and could effectively penetrate into tumors . The diameter enlargement was due to the encapsulation of the effective loading, as expected.…”

Section: Resultsmentioning

confidence: 96%

“…As shown in Figure 1e, the particle hydrodynamic size of the highly efficient tumor-targeted nanocarrier c(RGDyK)-HAase-IONP was 19.9 ± 3.9 nm, while it increased to 26.6 ± 4.7 nm after DOX was loaded, which was suitable for in vivo drug delivery and could effectively penetrate into tumors. 38 The diameter enlargement was due to the encapsulation of the effective loading, as expected. The particle size measured by DLS was slightly bigger than that measured by TEM, which can be ascribed to the dehydration and shrinkage of the nanoparticles when preparing the TEM sample.…”

Section: Preparation and Characterization Of The C-(rgdyk)-haase-ionp...mentioning

confidence: 99%

Targeted Nanodrugs to Destroy the Tumor Extracellular Matrix Barrier for Improving Drug Delivery and Cancer Therapeutic Efficacy

Chen

Xia

et al. 2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

One of the main reasons why most cancer patients do not respond well to chemotherapy is that drugs cannot accumulate in tumors at an optimal dose, eventually resulting in failure to prevent cancer cell growth. To improve drug delivery efficiency, we engineered a highly efficient tumor-targeted and stroma-breaking nanocarrier by the modification of iron oxide nanoparticles (IONPs) with a tumor-targeting peptide c(RGDyK) and a hyaluronidase (HAase) on the surface. The yielding nanocomplex, c(RGDyK)-HAase-IONP, targeted the tumor by binding integrin αvβ3 and went deeply into the tumors by the degradation of hyaluronic acid (HA), which was highly expressed in the tumor extracellular matrix (ECM). Good biostability and a low pH preferred drug release profile were characterized for c(RGDyK)-HAase-IONP carrying DOX in vitro. c(RGDyK)-HAase-IONP showed an improved tumor-targeting (2.5 times higher) effect after intravenous injection in the MC38 tumor-bearing mice model, as determined by whole-body fluorescence imaging compared to the non-targeted IONPs without HAase. After 5 systemic treatments, c(RGDyK)-HAase-IONP/DOX (5 mg/kg of equivalent dose of DOX) significantly inhibited MC38 tumor growth (22.1 ± 7.4 times relative to the non-treated group). Elevated apoptosis and reduced proliferation in the tumor cell were detected in the c(RGDyK)-HAase-IONP/DOX treated tumors compared to the control groups. Overall, the highly efficient targeted nanocarrier c(RGDyK)-HAase-IONP demonstrated tremendous potency for improving drug delivery and tumor therapy efficacy by targeted degradation of the dense HA barrier in the tumor ECM. We determined that such a tumor stroma–degrading nanosystem was capable of reducing tumor recurrence and drug resistance and could ultimately improve clinical tumor treatment responses.

show abstract

“…After stirring well, pure water (10 mL) was added to obtain celastrol-loaded coix seed oil microemulsion (CTM). 33 , 34 …”

Section: Methodsmentioning

confidence: 99%

Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil

Chen,

Zhang,

Qian

et al. 2024

IJN

Self Cite

View full text Add to dashboard Cite

Background A sequential release co-delivery system is an effective strategy to improve anti-cancer efficacy. Herein, multicomponent-based liposomes (TET-CTM/L) loaded with tetrandrine (TET) and celastrol (CEL)-loaded coix seed oil microemulsion (CTM) were fabricated, which showed synergistic anti-liver cancer activities. By virtue of Enhanced Permeability and Retention (EPR) effect, TET-CTM/L can achieve efficient accumulation at the tumor site. TET was released initially to repair abnormal vessels and decrease the fibroblasts, and CTM was released subsequently for eradication of tumor tissue. Methods TEM (transmission electron microscopy) and DLS (dynamic light scattering) were adopted to characterize the TET-CTM/L. Flow cytometry was adopted to examine the cellular uptake and cytotoxicity of HepG2 cells. The HepG2 xenograft nude mice were adopted to evaluate the anti-tumor efficacy and systemic safety of TET-CTM/L. Results TEM images of TET-CTM/L showed the structure of small particle size of CTM within large-size liposomes, indicating that CTM can be encapsulated in liposomes by film dispersion method. In in vitro studies, TET-CTM/L induced massive apoptosis toward HepG2 cells, indicating synergistic cytotoxicity against HepG2 cells. In in vivo studies, TET-CTM/L displayed diminished systemic toxicity compared to celastrol or TET used alone. TET-CTM/L showed the excellent potential for tumor-targeting ability in a biodistribution study. Conclusion Our study provides a new strategy for combining anti-cancer therapy that has good potential not only in the treatment of liver cancer but also can be applied to the treatment of other solid tumors.

show abstract

Furin-responsive triterpenine-based liposomal complex enhances anticervical cancer therapy through size modulation

Cited by 15 publications

References 79 publications

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer

Targeted Nanodrugs to Destroy the Tumor Extracellular Matrix Barrier for Improving Drug Delivery and Cancer Therapeutic Efficacy

Sequentially Released Liposomes Enhance Anti-Liver Cancer Efficacy of Tetrandrine and Celastrol-Loaded Coix Seed Oil

Contact Info

Product

Resources

About