Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes

Girennavar, Basavaraj; Poulose, Shibu M.; Jayaprakasha, G.K.; Bhat, Narayan G.

doi:10.1016/j.bmc.2005.11.039

Cited by 105 publications

(70 citation statements)

References 47 publications

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“…Furocoumarins in grapefruit interact with some orally administered drugs, increasing their bioavailability (Girennavar, Poulose, Jayaprakasha, Bhat, & Patil, 2006). In the current study, 6 0 ,7 0 -dihydroxybergamottin (DHB) levels were significantly lower at 7 and 35 days in degreened fruits; however, at 14 and 21 days the DHB contents were significantly higher in degreened fruits (Fig.…”

Section: 7-dihydroxybergamottinmentioning

confidence: 99%

Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit

2015

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Section: 7-dihydroxybergamottinmentioning

confidence: 99%

Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit

2015

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“…Antioxidant compounds have been characterized in Jaffa sweeties and white grapefruits. Citrus juice contains bioactive compounds such as limonoids, flavonoids, pectin, coumarins and furanocoumarins, and known antioxidants such as vitamin C and carotenoids, which have shown several health benefits (Girennavar, Poulose, Jayaprakasha, Bhat, & Patil, 2006;Poulose et al, 2005;Tian, Miller, Ahmad, Tang, & Patil, 2001;Vanamala et al, 2006). Based on current cell culture and animal studies in our lab and elsewhere, citrus flavonoids and limonoids have been shown to protect against a variety of chronic diseases such as atherosclerotic plaque formation and cancer (Poulose et al, , 2007Tanaka et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant capacity of pummelo and navel oranges: Extraction efficiency of solvents in sequence

Jayaprakasha

Girennavar

Patil

2008

LWT - Food Science and Technology

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“…However, in contrast to St John's wort, grapefruit inhibits the activity of several CYP isoenzymes. 93 These decreased metabolic rates result in higher concentrations of drug persisting in the bloodstream for a longer time. For benzodiazepam drugs, this results in an increased sedative effect and greater chances of coma.…”

Section: Precautions Using Herbal Medications In Special Circumstancesmentioning

confidence: 99%

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

Cock¹

2014

Phcog Commn.

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Background: Plants have been used therapeutically for thousands of years and continue to be the main treatment modality for a large percentage of the world's population. Furthermore, herbal medicine usage is increasing in Western countries as complementary (and sometimes alternative) treatments in conjunction with allopathic medicine. At the same time, the usage of allopathic medicines is being increasingly incorporated into the medicinal systems of developing countries, often resulting in the concurrent usage of both systems. Importance of the Study: Despite the widespread usage in developing countries and the trend of increasing medicinal plant usage in Western countries, herbal medicines remain understudied and there are misunderstandings amongst users and practitioners about the safe usage of these medications, particularly when used in conjunction with other medicines. Herbal medicines are generally not held to the same rigorous standards as allopathic medicines. There is usually a lack of industry regulation and manufacturing standards and guidelines, resulting in inferior (or unsafe) medicines being sold to consumers. Similarly, there is a lack of understanding amongst many medical practitioners of both traditional and allopathic medicine systems of how drugs from the two systems can be safely used together. Aim: The aim of this review is to summarise the current knowledge about herbal medicines and how they can be used safely, with the aim of not only highlighting some of the unsafe uses, but also to stimulate further research. I have also aimed to highlight the need for greater regulation and standardisation of herbal medicines.

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Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes

Cited by 105 publications

References 47 publications

Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit

Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit

Antioxidant capacity of pummelo and navel oranges: Extraction efficiency of solvents in sequence

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

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