“…This knowledge became clinically meaningful when it was observed that the intravenous administration of a loop diuretic in the course of urographic examination causes bilateral renal swelling in patients with essential hypertension, whereas in patients with unilateral renal artery stenosis such an effect is blunted on the affected side [5], On the basis of these observations, some authors pro posed the use of the so-called 'diuretic augmented excretory urography' as an improved method for the screening of renovascular hypertension [5][6][7]. Other investigators [8], however, failed to confirm the above findings and the method has not entered into widespread use.The differing results reported so far might be due to dif ferences in the study protocols, and/or to limitations inher ent in urography itself. As to the latter possibility, it has been shown that the administration of the contrast agent causes some enlargement of the kidney [3,9], which might well interfere with the effect of the loop diuretic on kidney size.…”