Furosemide for Packed Red Cell Transfusion in Preterm Infants: A Randomized Controlled Trial

Balegar, Kiran Kumar; Kluckow, Martin

doi:10.1016/j.jpeds.2011.05.022

Cited by 22 publications

(15 citation statements)

References 20 publications

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“…In a randomised control trial (RCT), Balegar and Kluckow15 demonstrated a significant increase in inhaled oxygen (FiO 2 ) requirement 24 hours post-transfusion in the placebo group compared with the frusemide group. However, the group receiving furosemide had an initial decrease in FiO 2 followed by a return to baseline levels after 24 hours post-transfusion.…”

Section: Commentarymentioning

confidence: 99%

QUESTION 2: Is frusemide necessary following red cell transfusion in preterm neonates?

Cosgrove

Molloy

2016

Arch Dis Child

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Section: Commentarymentioning

confidence: 99%

QUESTION 2: Is frusemide necessary following red cell transfusion in preterm neonates?

Cosgrove

Molloy

2016

Arch Dis Child

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“…1 Multiple blood draws causing anemia 2 and the need for increasing oxygen-carrying capacity 3 are the 2 main reasons for infants to receive a blood transfusion. 1 Multiple blood draws causing anemia 2 and the need for increasing oxygen-carrying capacity 3 are the 2 main reasons for infants to receive a blood transfusion.…”

Section: Is Lasix After a Blood Transfusion Necessary?mentioning

confidence: 99%

“…1 Other baseline variables such as heart rate, respiratory rate, hemoglobin, hematocrit, weight, and functional echocardiographic factors were compared between the 2 groups of neonates between 6 hours pre-blood transfusion and the 24 post-blood transfusion. 1 Other baseline variables such as heart rate, respiratory rate, hemoglobin, hematocrit, weight, and functional echocardiographic factors were compared between the 2 groups of neonates between 6 hours pre-blood transfusion and the 24 post-blood transfusion.…”

mentioning

confidence: 99%

Is Lasix After a Blood Transfusion Necessary?

Elser

2012

Advances in Neonatal Care

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necessity for the use of furosemide post-blood transfusion is necessary.To date, 3 studies have assessed the utility of furosemide post-blood transfusion. Two of the 3 studies were double-blind, randomized, placebo-controlled trials. In the first study, 20 infants born less than 28 weeks' gestation were randomized into either a placebo group or a furosemide group. 2 No differences were found between the 2 groups on the basis of neonatal characteristics. All blood transfusions (15 mL/kg over 3 hours) occurred within the first 2 weeks of life, and 12 of the 20 infants were randomized to the furosemide group (single dose, 1 mg/kg). A total of 13 clinical and ventilatory factors were collected from each infant before and after the blood transfusion. Examples of these factors include heart rate, peripheral oxygen saturation, FiO 2 , peak inspiratory pressure, and positive end-expiratory pressure. A comparison of these 13 factors between the placebo group and the furosemide group showed no statistically significant difference. A single dose of furosemide was shown not to change ventilator or clinical factors.In another double-blind, randomized, placebocontrolled trial, 40 neonates at least 7 days old and less than 37 weeks' gestation were enrolled to compare FiO 2 6 hours prior to a blood transfusion to FiO 2 levels in the 24 hours after the blood transfusion (20 mL/kg over 4 hours). 1 Other baseline variables such as heart rate, respiratory rate, hemoglobin, hematocrit, weight, and functional echocardiographic factors were compared between the 2 groups of neonates between 6 hours pre-blood transfusion and the 24 post-blood transfusion. Over the 30-hour period (6 hours pre-blood transfusion and 24 hours post-blood transfusion), those neonates receiving the placebo had a statistically significantly higher FiO 2 than those neonates who received furosemide (single dose, 1 mL/kg). Weight and serum sodium levels were significantly lower after the blood transfusion in those neonates who received furosemide than in the neonates in the placebo group. No other baseline variables were significant.In the last study, pulmonary function tests (baseline, immediately after blood transfusion, and

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“…While pre‐transfusion furosemide has been evaluated in neonates, to date there have been no studies to determine which interventions reduce the incidence of TACO in adults . Common recommendations include the use of single unit RBC transfusions, the selection of lower‐volume alternatives where applicable (e.g., prothrombin complex concentrates rather than plasma for warfarin reversal), and slowing infusion rates .…”

mentioning

confidence: 99%

“…A recent Cochrane meta‐analysis has concluded that there is an urgent need to determine the therapeutic utility of pre‐transfusion diuresis, preferably through the conduct of a randomized‐controlled trial . Given the significant morbidity and mortality caused by TACO, and the presence of clinical equipoise regarding the efficacy of furosemide in preventing it, we performed a pilot randomized controlled trial to determine the feasibility of performing a definitive multi‐center study.…”

mentioning

confidence: 99%

Can furosemide prevent transfusion‐associated circulatory overload? Results of a pilot, double‐blind, randomized controlled trial

et al. 2019

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show abstract

Furosemide for Packed Red Cell Transfusion in Preterm Infants: A Randomized Controlled Trial

Cited by 22 publications

References 20 publications

QUESTION 2: Is frusemide necessary following red cell transfusion in preterm neonates?

QUESTION 2: Is frusemide necessary following red cell transfusion in preterm neonates?

Is Lasix After a Blood Transfusion Necessary?

Can furosemide prevent transfusion‐associated circulatory overload? Results of a pilot, double‐blind, randomized controlled trial

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