Furostanolic saponins from <i>Trigonella foenum‐graecum</i> alleviate diet‐induced glucose intolerance and hepatic fat accumulation

Hua, Yinan; Ren, Sidney Y.; Guo, Rui; Rogers, Olivia; Nair, Rama; Bagchi, Debasis; Swaroop, Anand; Nair, Sreejayan

doi:10.1002/mnfr.201500197

Cited by 17 publications

(8 citation statements)

References 34 publications

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“…In both Ayurvedic and Chinese medicine, fenugreek leaves and seeds have long been known for the therapeutic efficacy in diabetes, muscle building and wrestling 1 , 7 , 21 - 25 . A number of studies have demonstrated that fenugreek attenuated body weight gain and improved insulin sensitivity 11 , 26 . The anti-diabetic efficacy of fenugreek seed extract was attributed due to the presence of furostanolic saponins and 4-hydroxyisoleucine 10 , 11 , 26 .…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies have demonstrated that fenugreek attenuated body weight gain and improved insulin sensitivity 11 , 26 . The anti-diabetic efficacy of fenugreek seed extract was attributed due to the presence of furostanolic saponins and 4-hydroxyisoleucine 10 , 11 , 26 . Hamden et al 28 demonstrated that administration of fenugreek seed extract to diabetic rats significantly decreased the sperm shape abnormality and improved the sperm count.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of Furosap^TM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

Maheshwari¹,

Verma

Swaroop³

et al. 2017

Int. J. Med. Sci.

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Background: Dietary fiber rich fenugreek (Trigonella foenum-graecum) seeds have exhibited cardioprotective, hypolipidemic and other health benefits. Furosap (FS), an innovative, patented, 20% protodioscin-enriched extract was developed in our laboratory from fenugreek seeds. This study examined the free and total testosterone levels, sperm profile and morphology, sexual health, mood and mental alertness, and broad spectrum safety parameters of FS in 50 male volunteers following supplementation over a period of 12 weeks.Methods: Institutional Review Board (IRB) and other regulatory approvals were obtained for our study. This one-arm, open-labelled, multi-center study was conducted in 50 male volunteers (age: 35 to 65 years) over a period of 12 weeks to determine the efficacy of FS (500 mg/day/subject) on free and total testosterone levels, sperm profile, sperm morphology, libido and sexual health, mood and mental alertness, and broad spectrum safety parameters.Results: Free testosterone levels were improved up to 46% in 90% of the study population. 85.4% of the study population showed improvements in sperm counts. Sperm morphology improved in 14.6% of volunteers. Majority of the subjects enrolled in the study demonstrated improvements in mental alertness and mood. Furthermore, cardiovascular health and libido were significantly improved. Extensive safety parameters were evaluated which included blood chemistry data. No significant changes were observed in serum lipid function, cholesterol, triglyceride, HDL and LDL levels, hemogram (CBC), hepatotoxicity and nephrotoxicity.Conclusion: Overall, the results demonstrate that FS, enriched in 20% protodioscin, is safe and effective in attenuating testosterone levels, healthy sperm profile, mental alertness, cardiovascular health and overall performance in human subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of Furosap^TM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

Maheshwari¹,

Verma

Swaroop³

et al. 2017

Int. J. Med. Sci.

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“…Our earlier animal studies revealed the broad-spectrum safety and anti-diabetic efficacy of fenugreek seed extract ( 28 , 29 ). In the present study, we assessed the efficacy of a novel, patented fenugreek seed extract enriched in furostanolic saponins (Fenfuro), to determine its anti-diabetic efficacy in a multicenter, placebo-controlled, double-blind, add-on clinical study in 154 diabetic subjects (male: 108; female: 46; age: 25–60 years) over a period of 90 consecutive days.…”

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confidence: 99%

A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes

Verma

Usman

Patel

et al. 2016

Food & Nutrition Research

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BackgroundTrigonella foenum-graecum (fenugreek) seeds are known to exhibit potent antioxidant, hypoglycemic, and nephroprotective activities, as well as serve as excellent membrane stabilizers especially because of their content of novel furostanolic saponins. Our previous studies exhibited the broad spectrum safety and efficacy of Fenfuro, a novel T. foenum-graecum seed extract enriched in furostanolic saponins, in type 2 diabetes (T2D) in rats.DesignThis multicenter, randomized, placebo-controlled, double-blind, add-on clinical study evaluated over a period of 90 consecutive days the efficacy of Fenfuro (daily dosage: 500 mg bid) in 154 subjects (male: 108; female: 46; age: 25–60 years) with T2D.MethodsThis study examined the body weight, blood pressure, and pulse rate, as well as the efficacy of Fenfuro on fasting and post-prandial plasma sugar (mg/dL), glycosylated hemoglobin (HbA1c), and fasting and post-prandial C-peptide levels.ResultsFenfuro caused significant reduction in both fasting plasma and post-prandial blood sugar levels. Approximately 83% of the subjects reported decreases in fasting plasma sugar levels in the Fenfuro-treated group as compared to 62% in the placebo group, while 89% of the subjects demonstrated reduction in post-prandial plasma sugar levels in the Fenfuro-treated group as compared to 72% in the placebo group. HbA1c levels were reduced in both placebo and treatment groups. The decrease in HbA1c levels was significant in both groups as compared to respective baseline values. A significant increase in fasting and post-prandial C-peptide levels compared to the respective baseline values was observed, while no significant changes in fasting and post-prandial C-peptide levels were observed between the two groups. No significant adverse effects were observed by blood chemistry analyses. Furthermore, 48.8% of the subjects reported reduced dosage of anti-diabetic therapy in the Fenfuro-treated group, whereas 18.05% reported reduced dosage of anti-diabetic therapy in the placebo group.ConclusionIn summary, Fenfuro proved safe and efficacious in ameliorating the symptoms of T2D in humans.

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“…FenfuroTM also dropped the assembly of fat and better insulin sensitivity and glucose acceptance. [53] It can be proved very useful in weight loss without any major side effect.…”

Section: Fenugreek Against Obesitymentioning

confidence: 99%

Nutritional and therapeutic properties of fenugreek (Trigonella foenum-graecum): a review

Syed

Rashid

Ahmad

et al. 2020

International Journal of Food Properties

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Current lifestyle, eating habits, stress, environmental factors and intensive use of synthetic chemicals in food processing and agriculture have radically increased the progression of several human diseases. Globally, researchers have been looking for natural therapeutic substances that can be used to treat or delay the onset of these lifestyle-related disorders. Numerous types of medicinal plants have shown the potential to be frequently used in the therapeutics due to the presence of several bioactive compounds. Among these, fenugreek is an important herb which has been recognized as an imperative medicinal plant by various scientists around the world. This herb has been widely reported as beneficial against numerous diseases such as cancer, hypercholesterolemia, diabetes and inflammation. Due to its medicinal value, the extracts/powders from different parts of fenugreek have been effectively utilized in food and pharmaceutical industries. Accordingly, the present review is an attempt to highlight the important nutritional benefits and curative applications of fenugreek as an effectual therapeutic agent against different diseases.

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Furostanolic saponins from Trigonella foenum‐graecum alleviate diet‐induced glucose intolerance and hepatic fat accumulation

Abstract: Collectively, our data suggest that fenugreek furostanolic saponins and green coffee bean extract may have potential benefits in treating insulin resistance and related conditions.

Cited by 17 publications

References 34 publications

Efficacy of Furosap^TM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

Efficacy of Furosap^TM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes

Nutritional and therapeutic properties of fenugreek (Trigonella foenum-graecum): a review

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Furostanolic saponins from Trigonella foenum‐graecum alleviate diet‐induced glucose intolerance and hepatic fat accumulation

Abstract: Collectively, our data suggest that fenugreek furostanolic saponins and green coffee bean extract may have potential benefits in treating insulin resistance and related conditions.

Cited by 17 publications

References 34 publications

Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

Efficacy of FurosapTM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (Fenfuro™) in patients with type 2 diabetes

Nutritional and therapeutic properties of fenugreek (Trigonella foenum-graecum): a review

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Efficacy of Furosap^TM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers

Efficacy of Furosap^TM, a novel Trigonella foenum-graecum seed extract, in Enhancing Testosterone Level and Improving Sperm Profile in Male Volunteers