Furrier's lung

Jc, Pimentel

doi:10.1136/thx.25.4.387

Cited by 39 publications

(10 citation statements)

References 13 publications

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“…Exposure to live birds is not necessary to produce hypersensitivity pneumonitis: the illness has resulted from using feather pillows and duvets (19), being exposed to a wreath made from the feathers of a dead pet bird (20), and laundering a pigeon keeper's overalls (21). Other examples of animal proteins that are known to have caused the disease when inhaled include proteins from the dust of mollusk shells used to make buttons (22) and from animal fur used in garment manufacture (23). Plant proteins that have provoked hypersensitivity pneumonitis include proteins found in a jellylike Japanese food that contains flour from a tuberous root and a powder derived from a brown alga (24).…”

Section: Etiologymentioning

confidence: 99%

Hypersensitivity Pneumonitis: A Historical, Clinical, and Radiologic Review

Hirschmann¹,

Pipavath²,

Godwin³

2009

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Most cases of hypersensitivity pneumonitis develop only after many years of inhaling allergens, which include microbes, animal or plant proteins, and certain chemicals that form haptens. The initial clinical presentation is either episodes of acute illness with dyspnea and prominent constitutional symptoms, such as fever, or an insidious onset of dyspnea, coughing, and weight loss, sometimes with superimposed acute episodes. The histopathologic process consists of chronic inflammation of the bronchi and peribronchiolar tissue, often with poorly defined granulomas and giant cells in the interstitium or alveoli. Fibrosis and emphysema may develop. The radiologic findings include diffuse ground-glass opacification, centrilobular ground-glass opacities, air trapping, fibrosis, lung cysts, and emphysema. The histologic and radiologic features in some cases may resemble those of usual interstitial pneumonia or nonspecific interstitial pneumonia. The diagnosis usually rests on a variable combination of findings from history, serology, radiography, lung biopsy, and bronchoalveolar lavage, which characteristically reveals a lymphocyte content of more than 30%, often with an increased CD4-to-CD8 ratio of T cells. Treatment includes avoiding the allergen, if possible, and, in severe cases, systemic corticosteroids. The long-term prognosis is usually good, but some patients develop severe respiratory insufficiency, and a few die of the disease.

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Section: Etiologymentioning

confidence: 99%

Hypersensitivity Pneumonitis: A Historical, Clinical, and Radiologic Review

Hirschmann¹,

Pipavath²,

Godwin³

2009

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152

112

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“…The classic description of lung pathology in Furrier's Lung is one of granulomas infiltrated with eosinophils in the lung parenchyma, eosinophilic infiltration of the airways as well as identification of fox hair in the excised tissue. [Pimentel, ]. Lung pathology in our patient showed no eosinophil infiltration in the airways or the interstitium and no animal hair within the interstitium despite grooming 8–9 dogs per day, 5 days a week.…”

Section: Discussionmentioning

confidence: 59%

“…Exposure to animal fur (specifically fox and astrakhan) and animal pelts have been known to cause HP (Furrier's Lung) [Pimentel, ]. This exposure is fundamentally different from exposures described by our patient with high level exposure to not only the fur of specific animals (fox, astrakhan, mink, leopard) but to animal serum and protein by virtue of exposure to the pelts of these animals.…”

Section: Discussionmentioning

confidence: 78%

Pet Groomer's Lung: A novel occupation related hypersensitivity pneumonitis related to pyrethrin exposure in a pet groomer

Rasheed

Sekosan

et al. 2016

American J Industrial Med

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A 61-year-old man was evaluated for a 2 month history of cough and dyspnea without relevant exposures other than pyrethrin containing insecticidal sprays he used while grooming dogs almost daily. High Resolution Computed Tomography (HRCT) of the chest demonstrated a Non-Specific Interstitial Pneumonia (NSIP) pattern. Pulmonary function testing revealed an isolated mildly reduced diffusion capacity. Bronchoalveolar lavage (BAL) results confirmed the presence of foamy histiocytes, lymphocytes, and polymorphonuclear cells consistent with ongoing exposure. Open lung biopsy showed poorly formed granulomas and bronchiolitis. He was advised to avoid exposure to pyrethrin. While he declined to stop grooming dogs, on follow-up, his symptoms had improved with use of a P100 mask and better ventilation to protect himself when using the pet sprays. We conclude that sustained exposure to pyrethrin containing sprays in the pet grooming industry may be a risk factor for a novel occupation related hypersensitivity pneumonitis. ("Pet Groomer's Lung"). Am. J. Ind. Med. 60:141-145, 2017. © 2016 Wiley Periodicals, Inc.

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“…The contact to the rabbit was very limited, and no source of high exposure to Cladosporium or Candida was identified. Hypersensitivity pneumonitis caused by animal hair has only been described in furrier's lung (11). Considering the high number of children exposed to furry animals in their home, it is striking to see these animals so seldom causing hypersensitivity pneumonitis, their allergenic nature being well known as a cause of IgE-mediated allergies.…”

Section: Discussionmentioning

confidence: 99%