Abstract.A field experiment was carried out at the Agriculture Research Station, Chitral, Pakistan in 2014 to determine the effect of sowing orientation, planting spacing and mulching on yield and weeds of potato crop, using a three factorial RCB design. The sowing orientation (Factor A) had two levels viz., north-south and east-west sowing, plant spacing (Factor B) with three levels of 15, 25 and 35 cm, and mulching (Factor C) of Cannabis sativa L. biomass as mulch, Plantago lanceolata L. biomass as mulch along with a hand weeded treatment and a weedy control. The experiment results revealed a significant effect of sowing orientation, planting spacing, mulching and their interactions on the crop and weeds. The east-west sowing resulted in an increased weed density and biomass, whereas the north-south direction produced greater plant heights, greater number of leaves, tuber weight plant -1 and tuber yield. Plant spacing of 35 cm showed a significant increase in weed density and biomass, number of leaves and tubers plant -1 and tuber weight plant -1. Plant spacing of 15 cm resulted in increased plant height and tuber yield. On the other hand, lowest weed density and biomass, number of leaves and tubers plant -1 and tuber weight were noted at planting space of 15 cm. Among the treatments of factor C, weedy check gave highest weed density and biomass ha -1 and plant heights, while the number of leaves and tubers plant -1 , tuber weight plant -1 and yield ha -1 were the highest in hand weeding treatments. The weedy check showed lowest number of leaves and tubers plant -1 , tuber weight plant -1 and yield ha -1 . In conclusion, the N-S sowing orientation, planting spacing of 15 cm and the mulching of plant biomasses of C. sativa and P. lanceolata proved the best combination for an environment-friendly weed management in potato at the higher elevations.