Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia

Trüeb, Ralph M.

doi:10.1159/000479333

Cited by 46 publications

(34 citation statements)

References 25 publications

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“…IGF-1 is involved in hair development via regulating cellular survival and proliferation, tissue remodelling, the hair cycle and follicular differentiation [ 34 , 35 ]. The production of IGF-1 in dermal papilla cells acquired from balding scalp is lower than that from non-balding scalp [ 36 , 37 ]. In this study, RGO along with its major components activated the Shh/Gli-1 pathway as well as growth factor in a mouse model, consequently triggering the anagen phase and hair growth.…”

Section: Discussionmentioning

confidence: 99%

Red ginseng oil promotes hair growth and protects skin against UVC radiation

Truong

Keum

Jeong

2021

Journal of Ginseng Research

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Background A wide range of environmental factors, such as diseases, nutritional deficiencies, ageing, hormonal imbalances, stress, and ultraviolet (UV) radiation, may affect the structure and function of the skin that covers the entire surface of the human body. In this study, we investigated roles of red ginseng oil (RGO) in enhancing skin functions, including hair growth and skin protection, using mouse models. Methods For hair growth experiment, shaved dorsal skins of C57BL/6 mice were topically applied with vehicle, RGO, RGO's major compounds, or minoxidil for consecutive 21 days and skin tissues were examined the hair growth promoting capacity. For skin protection experiment, SKH-1 hairless mice were topically applied with vehicle or RGO twice a day for three days prior to exposure to UVC radiation at 20 kJ/cm 2 . Skin tissues were collected to evaluate skin protective effects of RGO. Results Topical application of RGO to C57BL/6 mice effectively promoted hair regeneration by inducing early telogen-to-anagen transition and significantly increasing the density and bulb diameter of hair follicles. Major compounds, including linoleic acids and β-sitosterol, contributed to RGO-promoted hair growth. Treatment with RGO as well as its major components upregulated expression of hair growth–related proteins. Furthermore, in SKH-1 hairless mice, RGO had a protective effect against UVC-induced skin damage by inhibiting inflammation and apoptosis, as well as inducing cytoprotective systems. Conclusion These data suggest that RGO may be a potent agent for improving skin health and thereby preventing and/or treating hair loss and protecting skin against UV radiation.

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Section: Discussionmentioning

confidence: 99%

Red ginseng oil promotes hair growth and protects skin against UVC radiation

Truong

Keum

Jeong

2021

Journal of Ginseng Research

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“…However, to date, there is only one publication reporting the effects of MSC-EVs on hair growth [296]. The authors showed that mouse BM-MSC-EVs promoted proliferation of human DP cells and induced secretion of growth factors such as VEGF and IGF-1, which are essential for hair growth [285,297,298]. In addition, when mice were intradermally injected with BM-MSC-EVs, an increased anagen to telogen ratio was evident in C57BL/6 mice, along with elevated Wnt protein levels in the dorsal skin.…”

Section: The Effects Of Msc-exosomes On Hair Growthmentioning

confidence: 99%

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

Ha¹,

Kim²,

Lee

et al. 2020

Cells

358

231

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Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the characteristics of producer cells, exosomes can be utilized as cell-free therapeutics. Among exosomes derived from various cellular origins, mesenchymal stem cell-derived exosomes (MSC-exosomes) have gained great attention due to their immunomodulatory and regenerative functions. Indeed, many studies have shown anti-inflammatory, anti-aging and wound healing effects of MSC-exosomes in various in vitro and in vivo models. In addition, recent advances in the field of exosome biology have enabled development of specific guidelines and quality control methods, which will ultimately lead to clinical application of exosomes. This review highlights recent studies that investigate therapeutic potential of MSC-exosomes and relevant mode of actions for skin diseases, as well as quality control measures required for development of exosome-derived therapeutics.

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“…Hair growth can be regulated by controlling the proliferation, division, and apoptosis of hDPCs through the activity of growth and inhibitory factors such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and transforming growth factor- β 1 (TGF- β 1). IGF-1 is considered a representative hair growth factor that promotes epithelial cell proliferation and significantly increases the length of HF tissues [ 7 ]. Importantly, this factor also inhibits anagen to catagen transition [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Hair Growth Promotion Effect of Nelumbinis Semen Extract with High Antioxidant Activity

Park

Jin

Jung

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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This study investigated the hair regeneration promotion and hair loss prevention properties of Nelumbinis Semen (NS) extract in vitro and in vivo. The effect of NS on the proliferation and migration of human dermal papilla cells (hDPCs) was measured in vitro via CCK-8 and scratch migration assays, after which the antioxidant activity of NS was also quantified. NS extracts were then applied to the back of 7-week-old C57BL/6 mice for 3 weeks to monitor hair growth patterns and hair follicle (HF) histology. The mice were divided into three groups: negative control group (NC; DMSO), positive control group (PC; 3% minoxidil), and experimental group (NS extract 1,000 ppm). Moreover, to study the molecular mechanisms by which NS extract regenerates hair growth, real-time PCR was used to analyze factors related to the hair growth cycle. The NS extracts were found to possess high antioxidant properties due to their high flavonoid contents and electron-donating ability. Moreover, NS extracts enhanced hDPC proliferation and migration in a concentration-dependent manner (15.63–125 ppm). The hair growth index and growth area of the NS group (2.81 score, 81%) on day 14 were higher than those of the PC group (2.65 score, 68%) ( p < 0.05 ). Additionally, the HFs of the NS group were located deep in the subcutis, similar to the PC group with developed hair roots. Moreover, the mRNA expression of VEGF and IGF-1 was higher in the NS group compared to the PC group, whereas TGF-β1 expression was lower ( p < 0.05 ). Our findings indicate that NS modulates hair growth by increasing IGF-1 and VEGF expression while inhibiting that of TGF-β1. Therefore, our findings suggest that NS extract is a promising new hair loss treatment derived from a natural substance that helps promote hair growth and prevent hair loss.

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Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia

Cited by 46 publications

References 25 publications

Red ginseng oil promotes hair growth and protects skin against UVC radiation

Red ginseng oil promotes hair growth and protects skin against UVC radiation

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

Hair Growth Promotion Effect of Nelumbinis Semen Extract with High Antioxidant Activity

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