Further evidence for a cell surface proteinase essential to the growth of cultured fibroblasts

Scott, G. K.; Seow, Heng Fong

doi:10.1016/0014-4827(85)90429-x

Cited by 28 publications

(21 citation statements)

References 27 publications

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“…1 B, it should be possible to mimic selectively the specificity of individual members of the serpin family. Although the serpins have been described here as plasma proteins, some of them, such as the inhibitor of plasminogen activator (5,68) are primarily membrane bound. Ifthe specificity ofthese membrane-bound inhibitors can be reproduced, then it may be possible to influence cell proliferation, as has already been demonstrated in vitro using the argnine mutant of a -antitrypsin (68).…”

Section: Lung Disease and Treatmentmentioning

confidence: 99%

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.

Carrell¹

1986

J. Clin. Invest.

261

138

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Introduction: a,-antitrypsin and the serpins The maintenance of health requires a balance between the defensive and offensive systems ofthe body. One such balance that is now just becoming understood at the molecular level is the one between the enzymes that break down protein and the antiproteases that act as their inhibitors. Of particular importance is the group of closely related enzymes, the serine proteases, which are responsible for triggering the inflammatory cascades of the plasma such as coagulation, kinin release, fibrinolysis, and complement activation. The triggering by these enzymes of the plasma cascades is controlled by an appropriately specialized group of plasma protease inhibitors, e.g., antithrombin, antiplasmin, and the first component ofcomplement (C1)' inhibitor.

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Section: Lung Disease and Treatmentmentioning

confidence: 99%

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.

Carrell¹

1986

J. Clin. Invest.

261

138

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“…Previous studies have shown that AAT can inhibit the cellular growth of cultured fibroblasts [28] and the growth of some human tumour cell lines [29,30]. It is likely that AAT plays a role in controlling tissue destruction and tumour invasion by regulating specific trypsin-like enzymes that are being expressed by the neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Humoral Immunity in Oral Cancer Patients from a Nigerian Referral Centre

Akinmoladun

Arinola

Elumelu-Kupoluyi

et al. 2012

J. Maxillofac. Oral Surg.

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The immune system is central in the body's defense against non-self. Immunoglobulins and acute phase proteins have been reported to play active roles in carcinogenesis. This prospective longitudinal study was carried out to determine the state of humoral immunity in Nigerian oral cancer patients relative to controls. Twenty newly diagnosed untreated cases of oral squamous cell carcinoma recruited from our centre were included in the study. The controls included 20 apparently healthy and HIV negative volunteers. Serum immunoglobulin classes and acute phase proteins were measured using immunoplates. IgA and ceruloplasmin showed statistically significantly elevated levels in the patients compared with controls, while increases in IgM and IgG were insignificant. The raised levels suggest a role for immunoglobulin A and ceruloplasmin in the mechanisms involved in oral cancers. Findings from this study are similar to that reported elsewhere in the literature. Further work is needed to ascertain the role and usefulness of immunoglobulins and acute phase proteins in staging, disease monitoring, therapy and prognostication.

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“…Tissue culture techniques for established cell lines have been previously reported [5,10], as have methods for the measurement of cell-surface proteinase activity, and the inhibition of this activity, and of cell proliferation, by cci-proteinase inhibitor and by antiproteinase antibodies [5,6]. The established cell lines tested were human osteosarcomas, U2 OS (formerly 2T; [12]) and MG 63 [13].…”

Section: Methodsmentioning

confidence: 99%

Growth-Related Proteinases in Cultured Human Tumour Cells

Scott¹,

Tse²

1992

Biological Chemistry Hoppe-Seyler

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The proliferation of normal cells, and of early-passage cells from tumours, is inhibited as a consequence of inhibition of a cell-surface proteinase activity. In contrast, established tumour cell lines are usually resistant to these effects. It has previously been suggested that the change from sensitivity to resistance may be a consequence of tumour progression, but experiments with an additional three human tumour cell cultures show that this change is not inevitable.

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Further evidence for a cell surface proteinase essential to the growth of cultured fibroblasts

Cited by 28 publications

References 27 publications

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.

alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.

Evaluation of Humoral Immunity in Oral Cancer Patients from a Nigerian Referral Centre

Growth-Related Proteinases in Cultured Human Tumour Cells

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