Further Evidence of<i>Depdc7</i>Dna Hypomethylation in Depression: a Study in Adult Twins

Córdova‐Palomera, Aldo; Fatjó‐Vilas, Mar; Palma-Gudiel, Helena; Blasco-Fontecilla, Hilario; Kébir, Oussama; Fañanás, Lourdes

doi:10.1016/j.eurpsy.2015.04.001

Cited by 14 publications

(8 citation statements)

References 33 publications

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“…Although studies of methylation in strokes have indicated a range of changes in protein basal level [ 33 ], the targets of methylation regulation have not yet been the subject of a dedicated study. Proteins that have large basal level changes and are not miRNA targets (ACTA2 [ 34 ], C4BPA [ 35 ], CD3G [ 36 ], CENPK [ 37 ], DEPDC7 [ 38 ], FECH [ 39 ], HLA-DQA1 [ 40 ], HLA-DRB4 [ 41 ], and NKX3-1 [ 42 ]) can be potential targets of methylation regulations. Based on the specific targets of miRNA regulations and the position of the target proteins in the core networks, several potential drug targets can be selected (* in Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach

Chen

2016

IJMS

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While inflammation has generally been regarded as a negative factor in stroke recovery, this viewpoint has recently been challenged by demonstrating that inflammation is a necessary and sufficient factor for regeneration in the zebrafish brain injury model. This close relationship with inflammation suggests that a re-examination of the immune system’s role in strokes is necessary. We used a systems biology approach to investigate the role of immune-related functions via their interactions with other molecular functions in early cardioembolic stroke. Based on protein interaction models and on microarray data from the blood of stroke subjects and healthy controls, networks were constructed to delineate molecular interactions at four early stages (pre-stroke, 3 h, 5 h and 24 h after stroke onset) of cardioembolic stroke. A comparative analysis of functional networks identified interactions of immune-related functions with other molecular functions, including growth factors, neuro/hormone and housekeeping functions. These provide a potential pathomechanism for early stroke pathophysiology. In addition, several potential targets of miRNA and methylation regulations were derived based on basal level changes observed in the core networks and literature. The results provide a more comprehensive understanding of stroke progression mechanisms from an immune perspective and shed light on acute stroke treatments.

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Section: Resultsmentioning

confidence: 99%

Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach

Chen

2016

IJMS

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“…A twin-based approach previously developed in our group [55] was also applied to refine the association between cg06793497 methylation and CPR. Briefly, intrapair differences for both variables of interest were computed for each twin pair; afterward, a regression model was fitted with an estimated intrapair cg06793497 methylation (Δmethylation) and intrapair CPR (ΔCPR).…”

Section: Methodsmentioning

confidence: 99%

Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene

et al. 2019

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Background Obstetric complications have long been retrospectively associated with a wide range of short- and long-term health consequences, including neurodevelopmental alterations such as those observed in schizophrenia and other psychiatric disorders. However, prospective studies assessing fetal well-being during pregnancy tend to focus on perinatal complications as the final outcome of interest, while there is a scarcity of postnatal follow-up studies. In this study, the cerebroplacental ratio (CPR), a hemodynamic parameter reflecting fetal adaptation to hypoxic conditions, was analyzed in a sample of monozygotic monochorionic twins (60 subjects), part of them with prenatal complications, with regard to (i) epigenetic age acceleration, and (ii) DNA methylation at genes included in the polygenic risk score (PRS) for schizophrenia, and highly expressed in placental tissue. Results Decreased CPR measured during the third trimester was associated with epigenetic age deceleration (β = 0.21, t = 3.362, p = 0.002). Exploration of DNA methylation at placentally expressed genes of the PRS for schizophrenia revealed methylation at cg06793497 ( EP300 gene) to be associated with CPR (β = 0.021, t = 4.385; p = 0.00008, FDR-adjusted p = 0.11). This association was reinforced by means of an intrapair analysis in monozygotic twins discordant for prenatal suffering (β = 0.027, t = 3.924, p = 0.001). Conclusions Prenatal adverse environment during the third trimester of pregnancy is associated with both (i) developmental immaturity in terms of epigenetic age, and (ii) decreased CpG-specific methylation in a gene involved in hypoxia response and schizophrenia genetic liability. Electronic supplementary material The online version of this article (10.1186/s13148-019-0674-5) contains supplementary material, which is available to authorized users.

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“…Brain expression of DEPDC7 was not detectable. However, it has been suggested that DEPDC7 DNA hypomethylation may be associated with depression (Córdova-Palomera et al, 2015). The biological function of the protein encoded by the DEPDC7 (DEP domain-containing 7) gene is poorly understood.…”

Section: Ddx25 (Dead (Asp-glu-ala-asp) Box Polypeptidementioning

confidence: 99%

Identification of candidate genes for developmental colour agnosia in a single unique family

et al. 2021

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Colour agnosia is a disorder that impairs colour knowledge (naming, recognition) despite intact colour perception. Previously, we have identified the first and only-known family with hereditary developmental colour agnosia. The aim of the current study was to explore genomic regions and candidate genes that potentially cause this trait in this family. For three family members with developmental colour agnosia and three unaffected family members CGH-array analysis and exome sequencing was performed, and linkage analysis was carried out using DominantMapper, resulting in the identification of 19 cosegregating chromosomal regions. Whole exome sequencing resulted in 11 rare coding variants present in all affected family members with developmental colour agnosia and absent in unaffected members. These variants affected genes that have been implicated in neural processes and functions (CACNA2D4, DDX25, GRINA, MYO15A), that have a indirect link to brain function or development (MAML2, STAU1, TMED3), and a remaining group lacking brain expression or involved in non-neural traits (DEPDC7, OR1J1, OR8D4, RABEPK). Although this is an explorative study, the small set of candidate genes that could serve as a starting point for unravelling mechanisms of higher level cognitive functions and cortical specialization, and disorders therein such as developmental colour agnosia.

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Further Evidence ofDepdc7Dna Hypomethylation in Depression: a Study in Adult Twins

Cited by 14 publications

References 33 publications

Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach

Key Immune Events of the Pathomechanisms of Early Cardioembolic Stroke: Multi-Database Mining and Systems Biology Approach

Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene

Identification of candidate genes for developmental colour agnosia in a single unique family

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