2006
DOI: 10.1016/j.ijcard.2005.04.030
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Further evidence of inflammation in chronic rheumatic valve disease (CRVD): High levels of advanced oxidation protein products (AOPP) and high sensitive C-reactive protein (hs-CRP)

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Cited by 60 publications
(59 citation statements)
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“…Furthermore, oxidative stress may also increase the levels of TnC (7,30,31). Previous studies have shown increased oxidative stress in ARF and rheumatic HVD and have also suggested that this plays a role in the pathogenesis of rheumatic carditis (18,32,33). Increased oxidative stress in ARF has been reported to be the result of the increase in several oxidative stress indicators and also the decrease in antioxidant parameters (32)(33)(34).…”
Section: Discussionmentioning
confidence: 96%
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“…Furthermore, oxidative stress may also increase the levels of TnC (7,30,31). Previous studies have shown increased oxidative stress in ARF and rheumatic HVD and have also suggested that this plays a role in the pathogenesis of rheumatic carditis (18,32,33). Increased oxidative stress in ARF has been reported to be the result of the increase in several oxidative stress indicators and also the decrease in antioxidant parameters (32)(33)(34).…”
Section: Discussionmentioning
confidence: 96%
“…One study found that both malonyldialdehyde and several antioxidant enzymes were increased in ARF (35). Chiu-Braga et al (18) detected that the levels of advanced oxidation protein products were significantly elevated in patients with rheumatic HVD, compared to the controls. Therefore, oxidative stress may be considered to play a role in the high TnC levels of those with rheumatic HVD.…”
Section: Discussionmentioning
confidence: 99%
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“…Chiu-Braga et al, [11] examined oxidative status of patients with rheumatic heart valve disease (HVD) using advanced oxidation protein products. In concordance with our results, they found that levels of advanced oxidation protein products were significantly elevated in rheumatic HVD patients compared to controls and that these elevated levels were not correlated with the severity of mitral disease.…”
Section: Discussionmentioning
confidence: 99%
“…Many infections, including syphilis, are associated with antiphospholipid antibodies, and these antibodies may contribute to the formation of atherosclerotic thrombosis (36). Elevated highsensitivity C-reactive protein levels have been found not only in patients with rheumatic fever, but also in patients with chronic rheumatic valve disease, suggesting the persistence of inflammation even after the initial infection (10,37). Modification of low-density lipoprotein (LDL) particles caused by oxidation is an important step in the process of atherogenesis, and antibodies against oxidized LDL have been found in many diseases, including rheumatic fever (38).…”
Section: Discussionmentioning
confidence: 99%