Further flavonol and iridoid glycosides from <i>Ajuga remota</i> aerial parts

Manguro, Lawrence Onyango Arot; Ogur, Joseph A.; Okora, Dennis Magio; Wagai, Samuel Otieno; Lemmen, Peter

doi:10.1080/10286020600979480

Cited by 15 publications

(3 citation statements)

References 17 publications

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“…These efforts have led to the isolation of a number of compounds, including phytoecdysteroids [7], neo-clerodane diterpenes, diterpenoids (ajugarin I, II, III, IV &V, and others) [8], triterpenes, specific-sterols like beta-sitosterol, gamma-sitosterol, ceryl alcohol, anthocyanidin-glucosides, iridoid glycosides [4, 9], flavonol glycosides [4], quinolones, withanolides, flavonoids, tannins, triglycerides and essential oils [10]. …”

Section: Introductionmentioning

confidence: 99%

Antidiarrheal activity of 80 % methanol extract of the aerial part of Ajuga remota Benth (Lamiaceae) in mice

Yacob

Shibeshi

Nedi

2016

BMC Complement Altern Med

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BackgroundIn the Ethiopian traditional medicine, the aerial part of Ajuga remota Benth is used in the treatment of diarrhea. There are different mechanisms by which Ajuga remota may have antidiarrheal effect. Some of the possible mechanisms are through its anthelmintic and antibacterial activity. The present study aimed to evaluate whether the antidiarrheal effect of the plant also include antimotility and antisecretory effect using 80 % methanol extract of A. remota (MEAR).MethodsThe MEAR was administered at doses of 200, 400, 600 and 800 mg/kg to four groups of mice (six animals per group) orally in castor oil diarrhea model. The effect of the extract on enteropooling and gastrointestinal transit model was also evaluated using the same grouping and dosing. Two other groups, one as control and the other as standard (loperamide 5 mg/kg) were used for comparison with the treatment groups.ResultsThe extract at the doses of 400, 600, and 800 mg/kg produced a dose-dependent and significant inhibition both on the frequency and onset of diarrhea. The percentage purging frequency was 53.4, 66.7, 79.6, and 66.7 % (p < 0.001) at three doses of MEAR (400, 600, and 800 mg/kg) and with loperamide (5 mg/kg), respectively. The percentage inhibition in intestinal fluid accumulation was 42.5, 62.1, and 74.2 % (p < 0.001) at the doses of 400, 600 and 800 mg/kg of MEAR, respectively. The MEAR also inhibited the intestinal transit of charcoal meal in a dose dependent manner both in the normal and castor oil induced intestinal transit.ConclusionThis study has shown that the 80 % methanol extract of A. remota contains pharmacologically active substances with significant antimotility and antisecretory effect contributing for its antidiarrheal activity.

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Section: Introductionmentioning

confidence: 99%

Antidiarrheal activity of 80 % methanol extract of the aerial part of Ajuga remota Benth (Lamiaceae) in mice

Yacob

Shibeshi

Nedi

2016

BMC Complement Altern Med

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“…Much phytochemical research has assessed the separation of Ajuga ingredients. These studies have led to the isolation of several secondary metabolites, including neo-clerodane_diterpenes and diterpenoids, phytoecdysteroid components, flavonoid derivatives, iridoids, sesquiterpenoid compounds, withanolides, phenylethanoid glycoside derivatives, sterols, anthocyanins, and O-coumaric acid compounds (3,8,12,13,15,23,29,34,39,40,(45)(46)(47)(48)(49)(50)(51). Isolated compounds from different Ajuga species growing in Iran are shown in Table 2.…”

Section: Phytochemicalsmentioning

confidence: 99%

Medicinal Importance of Ajuga Species in Iran: Ethnobotanical and Traditional Applications, Phytochemical, and Pharmacological Studies

Rahiminiya

Ghadim

Lamardi

et al. 2022

Jundishapur J Nat Pharm Prod

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Context: Five species of the genus Ajuga (Lamiaceae) having the common name of "bugle" are found in Iran. In Persian medicine (PM), the genus Ajuga (Kamaphytus) is used for treating jaundice, joint pain, gout, amenorrhea, sciatica, and wound healing. This study aimed to review the ethnobotanical, phytochemical, and biological activities of Ajuga species that grow in Iran to determine their therapeutic potentials and suggest further studies on the healing properties of this genus in Iran. Evidence Acquisition: Electronic databases such as PubMed, Scopus, and Google Scholar were comprehensively searched for studies on Ajuga species in Iran, including "Ajuga austro-iranica," "Ajuga chamaecistus," "Ajuga comata" (Syn.: "Ajuga Chia," "Ajuga chamaepitys subsp. Chia"), "Ajuga orientalis," and "Ajuga reptans." The search period was from 1966 to February 2021. The related articles were selected according to the inclusion and exclusion criteria of the current study. Results: Several ethnobotanical and pharmacologic reports have verified the traditional uses of the genus Ajuga for anti-inflammatory, hypoglycemic, hypolipidemic, analgesic, anabolic, anti-arthritis, antipyretic, and hepatoprotective activities. Numerous phytochemicals have been identified from Ajuga species involving phytoecdysteroids, neo-clerodane-diterpenes, iridoids, flavonoids, withanolides, phenylethyl glycoside, and essential oils. Conclusions: Due to the beneficial therapeutic effects of Ajuga genus, it can be considered in future clinical studies as a source of natural antioxidants, dietary supplements in the pharmaceutical industry, and stabilizing food against oxidative deterioration.

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“…As well, many phytochemical studies on Ajuga species have been performed which have led to the isolation of phytoecdysteroids [ 11 , 12 ], neo- clerodanediterpenoids [ 13 ], phenylethyl glycosides [ 3 ], withanolides [ 2 ], iridoids and flavonoids [ 14 ], and essential oils [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive effect of some extracts from Ajuga chamaecistus Ging. ssp. tomentella (Boiss.) Rech. f. aerial parts

et al. 2014

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BackgroundThe genus Ajuga is used for the treatment of joint pain, gout, and jaundice in traditional Iranian medicine (TIM). Ajuga chamaecistus ssp. tomentella is an exclusive subspecies of Ajuga chamaecistus in the flora of Iran. The aim of this study was to evaluate antinociceptive properties of some extracts from aerial parts of A. chamaecistus ssp. tomentella.MethodsAntinociceptive activities of total water and 80% methanol extracts, hexane, diethyl ether and n-butanolic partition fractions of the methanolic extract were analyzed using the formalin test in mice. Indomethacin (10 mg/kg) and normal saline were employed as positive and negative controls, respectively.ResultsOral administration of all extracts (200, 400 and 600 mg/kg) 30 min before formalin injection had no effect against the acute phase (0–5 min after formalin injection) of the formalin-induced licking time, but hexane fraction (200 mg/kg) caused a significant effect (p < 0.001) on the chronic phase (15–60 min after formalin injection). Total water and diethyl ether extracts at a dose of 400 mg/kg showed a very significant analgesic activity on the chronic phase (p < 0.001 and p < 0.01, respectively).ConclusionsThe results of this study suggest that the extracts of A. chamaecistus ssp. tomentella have an analgesic property that supports traditional use of Ajuga genus for joint pain and other inflammatory diseases.

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Further flavonol and iridoid glycosides from Ajuga remota aerial parts

Cited by 15 publications

References 17 publications

Antidiarrheal activity of 80 % methanol extract of the aerial part of Ajuga remota Benth (Lamiaceae) in mice

Antidiarrheal activity of 80 % methanol extract of the aerial part of Ajuga remota Benth (Lamiaceae) in mice

Medicinal Importance of Ajuga Species in Iran: Ethnobotanical and Traditional Applications, Phytochemical, and Pharmacological Studies

Antinociceptive effect of some extracts from Ajuga chamaecistus Ging. ssp. tomentella (Boiss.) Rech. f. aerial parts

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