Further follow up of mortality in a United Kingdom oil distribution centre cohort.

Rushton, Lesley

doi:10.1136/oem.50.6.561

Cited by 25 publications

(12 citation statements)

References 27 publications

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“…The general results from both studies are first described briefly [full details are given elsewhere (12,13,63,64)], followed by a report of the findings for kidney cancer and leukemia. Table 2 gives the observed and expected deaths, the SMR, and the 95% confidence interval for the SMR for all causes of death and all neoplasms for the total refinery and distribution center populations; separately for the first follow-up period, 1951-1975; the second follow-up period, 1976-1989; and the total follow-up period, .…”

Section: Mortality Resultsmentioning

confidence: 99%

A 39-year follow-up of the U.K. oil refinery and distribution center studies: results for kidney cancer and leukemia.

Rushton

1993

Environ Health Perspect

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This paper presents briefly some of the principal results of a mortality analysis of a cohort of workers employed for at least 1 year between 1950 and 1975 at eight oil refineries and approximately 750 distribution centers in the U.K, together with detailed results for kidney cancer and leukemia. Over 99% of the workers were successfully traced. Their mortality was compared with that of all males in the national population. The mortality from all causes of death is lower than that ofthe comparison population in both studies, and reduced mortality is also found for many of the major nonmalignant causes of death. In the refinery study, some increased mortality patterns are found for diseases of the arteries, and no healthy worker effect is found in the distribution center study for ischemic heart disease. Mortality from all neoplasms is lower than expected overall in both studies, largely due to a deficit of deaths from malignant neoplasm of the lung. Mortality from malignant neoplasm of the kidney is increased overall in the distribution center study, and in drivers in particular. The mortality from this disease increases with increased time since first exposure. The observed deaths from leukemia are slightly less than expected in the refinery study and slightly more than expected in the distribution center study. One refinery shows increased mortality due to in myeloid leukemia, and mortality is increased among refinery operators. Mortality is also raised in distribution center drivers, particularly for myeloid leukemias, including acute myeloid leukemia.

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Section: Mortality Resultsmentioning

confidence: 99%

A 39-year follow-up of the U.K. oil refinery and distribution center studies: results for kidney cancer and leukemia.

Rushton

1993

Environ Health Perspect

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“…Exce ss risks for brain tumors have been associated with employment in petroleum refining (49). Finally, increa sed risks of kidney cancer , leukemia, and cancers of the larynx and prostate were found in a cohort of 23 306 British oil distribution workers (50).…”

Section: Resultsmentioning

confidence: 99%

Mortality of filling station attendants.

Lagorio

Forastiére²,

Iavarone³

et al. 1994

Scand J Work Environ Health

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A. Mortality of filling station attendants. Scand J Work Environ Health 1994;20:331-8. OBJECTIV ES -Gasoline contains established human carcinogens, such as benzene. The health impact of exposure to this fuel, however, has not been fully elucidated. We report on the mortality of a cohort of 2665 filling station managers from the Latium region (Italy).M ETHODSThis is the first workplace-based cohort of gas station attendants. However, only selfemployed individuals were available for study (about 50% of the whole work force). The follow-up period extended from 1981 through 1992. The mortality experience of the cohort was compared with that of the regional population. RESULTS -The overall analysis for standardized mortality ratios (SMR) showed a significantly decreased mortality from all causes, mainly due to a deficit of cardiovascular diseases and malignant neoplasms. Nonsignificantly increased risks for esophageal cancer [SMR 241, 90% confidence interval (90% CI) 82-551] , brain cancer (SMR 195,90% CI 77-401) and non-Hodgkin's lymphoma (SMR 173,90% CI 47-448) were found for the men; mortality due to lung cancer and leukemia was lower than expected, and no kidney cancer death was recorded. Among the attendants of small stations (characterized by a small number of employees and high sales of gasoline per full-time employee), the SMR values for esophageal cancer (for men SMR 35 1, 90% CI 120-803) and brain cancer (for men and women SMR 266, 90% CI 105-559) showed increased values. CONCLUSIONS -Filling station attendants are exposed to gasoline vapors and seem at risk of cancer of various sites. Due to the power limitations of this study, however, a precise estimate of the risk for many causes of death was not achievable. Further cohort studies of greater size are warranted.

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“…Kemp et al (1980) suggested that a rise in the incidence of acute myeloid leukaemia between 1968-72 and 1973-77, shown in Scottish cancer registration data, was partly because of better diagnosis and partly because of a real increase, but not because of an improvement in registration. Bowie (1987) (Rushton and Alderson, 1983) and the second to 1989 (Rushton, 1993). In the second follow-up some excess mortality was found from leukaemia, in particular acute myeloid leukaemia, which has been associated in other studies with possible exposure to benzene (Vigliani, 1976;Brandt et al, 1978;Aksoy, 1989) …”

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confidence: 90%

Comparison of the diagnosis of leukaemia from death certificates, cancer registration and histological reports - implications for occupational case-control studies

Rushton

Romaniuk²

1997

Br J Cancer

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Summary It is essential in occupational case-control studies of rare diseases for ascertainment to be as complete as possible, together with an accurately defined diagnosis. A nested case-control study from a large cohort of UK oil distribution workers followed up since 1950 was carried out to investigate the association between leukaemia, in particular acute myeloid leukaemia, and exposure to benzene. Ninety-one cases occurring before 1993 were identified from death certificates or cancer registrations (available from 1971). Histopathology departments were contacted to obtain material that might confirm the diagnosis of leukaemia and this was received for 39 (43%) cases. The majority of the cases (88) were identified primarily from death certificates, with a cancer registration also being received for 56 (90%) of the 62 deaths occurring after 1971. Discrepancies in the diagnoses from these two sources were found for 12 cases, five being acute myeloid leukaemia. For the majority, the diagnosis on the death certificate was more specific than that on the cancer registration. Histology reports were received for nine of the discrepancies, all confirming the death certificate diagnosis. Although leukaemia appears to be regularly registered as a cancer, records may not be routinely updated when new clinical information becomes available. It is recommended that death certificates, cancer registrations and histology reports are obtained routinely by cancer registries to maximize both numbers of cases and diagnostic accuracy for epidemiological studies.

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Further follow up of mortality in a United Kingdom oil distribution centre cohort.

Cited by 25 publications

References 27 publications

A 39-year follow-up of the U.K. oil refinery and distribution center studies: results for kidney cancer and leukemia.

A 39-year follow-up of the U.K. oil refinery and distribution center studies: results for kidney cancer and leukemia.

Mortality of filling station attendants.

Comparison of the diagnosis of leukaemia from death certificates, cancer registration and histological reports - implications for occupational case-control studies

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