Further Improvement in Outcomes of Nasopharyngeal Carcinoma With Optimized Radiotherapy and Induction Plus Concomitant Chemotherapy: An Update of the Milan Experience

Palazzi, Mauro; Orlandi, Ester; Bossi, Paolo; Pignoli, E.; Potepan, Paolo; Guzzo, Marco; Franceschini, Marzia; Scaramellini, G.; Cantù, Giulio; Licitra, Lisa; Olmi, Patrizia; Tomatis, S.

doi:10.1016/j.ijrobp.2008.08.068

Cited by 37 publications

(28 citation statements)

References 26 publications

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“…Evaluation of DVH analysis showed that our GTV DVH curves are slightly left-shifted compared to reported series [22,27] (Table 4). Lee et al [22] explained the tumor overdosage by the fact that the prescribed dose was the minimum dose that encompassed the tumor target volume.…”

Section: Disease Controlmentioning

confidence: 55%

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Simultaneous Integrated Boost Intensity‑Modulated Radiotherapy (SIB‑IMRT) in Nasopharyngeal Cancer

et al. 2010

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Section: Disease Controlmentioning

confidence: 55%

“…However, the local failure rate remains still > 10% in patients with T3/T4 tumors [7,15,16,18,22,27,40,43].…”

Section: Disease Controlmentioning

confidence: 99%

Simultaneous Integrated Boost Intensity‑Modulated Radiotherapy (SIB‑IMRT) in Nasopharyngeal Cancer

et al. 2010

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“…However, it is a highly frequent epithelial malignancy of the head and neck in southern China and parts of Southeast Asia, with a reported annual incidence of 30-80 per 10 5 persons in endemic regions, mainly owing to Asian ancestry and infection with the Epstein-Barr virus. [1][2][3] The mainstay of treatment for nasopharyngeal cancers is using 100 mg m 22 of cisplatin on Days 1, 22 and 43 concurrent with radiotherapy, followed by adjuvant 80 mg m 22 of cisplatin on Day 1 and 1000 mg m 22 of 5-fluorouracil on Days 1-4 for three cycles. 4,5 It is known that stage-adapted therapy significantly improved the survival of patients with cancer.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of diagnostic value of 18F-FDG PET or PET/CT for detecting lymph node and distant metastases in patients with nasopharyngeal carcinoma

Shen¹,

Zhang²,

Jia³

et al. 2014

The British Journal of Radiology

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The authors Guohua Shen and Wenjie Zhang contributed equally to this work.Objective: We performed this meta-analysis to comprehensively assess the diagnostic performance of positron emission tomography (PET) or PET/CT for detecting lymph node and distant metastases in patients with nasopharyngeal carcinoma (NPC). Methods: Through a search of four English and three Chinese databases (January 1990 to June 2013), pooled estimated sensitivity, specificity and diagnostic odds ratio (DOR) were calculated based on the data extracted from the included studies. We also constructed summary receiver operating characteristic curves, with the area under the curve (AUC) and obtained the Q* index. Heterogeneity and subgroup analysis were also performed. Conclusion:The present meta-analysis showed that PET or PET/CT has excellent diagnostic performance for detecting lymph node and distant metastases in patients with NPC. Advances in knowledge: To provide evidence to assess the role of PET or PET/CT in staging of NPC.

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“…Recent developments in radiotherapy technology, such as intensity-modulated radiation therapy (IMRT) and three-dimensional (3D) radiotherapy, allow precise energy transfer to the tumor, which has improved local control rates (Onishi et al, 2004;Palazzi et al, 2009). However, the emergence of tolerant cells during or after radiotherapy remains problematic (Peters et al, 1985;Peters et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

Increased Motility and Invasiveness in Tumor Cells That Survive 10 Gy Irradiation

Tsutsumi

Tsuda

Yazawa

et al. 2009

Cell Struct. Funct.

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ABSTRACT. Radiotherapy is an important noninvasive treatment for many types of cancer. However, it has been reported that the proliferative, invasive, and metastatic capacities of tumor cells can be increased in the repopulated tumors that survive radiotherapy. We have previously established a radiation-surviving cell model for the human non-small cell lung cancer cell line H1299 by harvesting relic cells 14 days after irradiation (IR cells). Here, we report that cell invasion, cell migration, and cell adhesion are enhanced in these surviving cancer cells. The mRNA expression levels of matrix metalloproteinases (MMPs), including mmp1, mmp2, and mmp9, were upregulated in IR cells compared with parental cells. A gelatin zymogram, wound healing assay, and invasion assay showed increased MMP activity, cell motility, and invasiveness in IR cells, respectively. Moreover, IR cells adhered more tightly to collagen-coated dishes than parental cells. Consistently, paxillin, phosphorylated FAK, integrin β1, and vinculin were strongly localized at focal adhesions in IR cells, as visualized by immunofluorescence. In this report, we identify molecules responsible for the malignant properties of tumor cells that survive irradiation. These molecules may be important therapeutic targets for the control of repopulated tumors after radiotherapy.

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Further Improvement in Outcomes of Nasopharyngeal Carcinoma With Optimized Radiotherapy and Induction Plus Concomitant Chemotherapy: An Update of the Milan Experience

Cited by 37 publications

References 26 publications

Simultaneous Integrated Boost Intensity‑Modulated Radiotherapy (SIB‑IMRT) in Nasopharyngeal Cancer

Simultaneous Integrated Boost Intensity‑Modulated Radiotherapy (SIB‑IMRT) in Nasopharyngeal Cancer

Meta-analysis of diagnostic value of 18F-FDG PET or PET/CT for detecting lymph node and distant metastases in patients with nasopharyngeal carcinoma

Increased Motility and Invasiveness in Tumor Cells That Survive 10 Gy Irradiation

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