Further investigations on the cytological effects of some contraceptives

17 ?ethynylestradiol and norgestrel in combination induce micronucleus increases and aneuploidy in human lymphocyte and fibroblast cultures

“…Murthy and Prema [27,28], observed a significantly increased frequency of sister chromatid exchanges in OC users. Furthermore, some widely used OCs, such as Stediril, Anovlar, and Lyndol, produced genotoxic effects on chromosomes of root tips of Allium cepa [29] [Bukvic and Sofradzija unpublished data]. Finally, Banduhn and Obe [30] showed that, in vitro, estradiol had clear C-mitotic effects and induced both polyploidy and increased micronucleus frequency in human peripheral lymphocytes.…”

Somatic chromosomal aberrations induced by benzoylphenylurea (XRD 473 and IKI 7899) in Vicia faba L. and Hordeum vulgare L.

“…It has been shown that such cells could arise from multipolar ana-telophase cells and/or anaphases with lagging chromosomes (Amer and Farah 1974, 1975, Kabarity and Mazrooei 1984and Elnadi et al 1983). …”