Further Isolations of Reovirus Type 3 from Cases of Burkitt's Lymphoma

Bell, Thomas M.; Massie, Alexander; Ross, M. G. R.; Simpson, David; Griffin, Elizabeth

doi:10.1136/bmj.1.5502.1514

Cited by 42 publications

(1 citation statement)

References 23 publications

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“…At the same time, several isolations of novel Reoviridae family viruses were obtained by Thomas Bell and colleagues at the Imperial Cancer Research Fund (ICRF) in Uganda. These discoveries were documented in prestigious journals, such as the British Journal of Medicine (37), but finally dropped in favour of EBV by the scientific community. Our re-discovery of MFRVs in cases of BL in Switzerland -where it is difficult to object that Reoviruses would be isolated in view of poor hygienic conditions -strongly argues in favour of an important role for this family of viruses in BL pathogenesis (30).…”

Section: Question: How Is Your Model Evaluated In the Following Years?mentioning

confidence: 99%

Neuroblastoma in childhood and its potential viral involvement: A webinar by the Paediatric Virology Study Group

Rovigatti

Papaioannou

Mammas³

et al. 2022

World Acad Sci J

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Neuroblastoma represents the most common and lethal solid tumour of early childhood. In view of variations in genetic elements, MYCN amplification is certainly the most prominent genetic factor occurring in 1/4 or 1/5 of children with neuroblastoma; however, overall, the pathogenesis of neuroblastoma remains to be resolved. Rare, sporadic infections with Epstein-Barr, hepatis C virus and varicella-zoster virus have been detected in children with neuroblastoma, while the presence of BK virus was initially claimed, but later falsified as a triggering factor for the development of high-risk neuroblastoma. The proposed model by Professor Ugo Rovigatti, Professor of Molecular Biology at the University of Florence in Italy, is based upon infection with micro-foci inducing virus and its potential tumorigenic role as trigger of i) high and persistent inflammation; ii) chromothripsis and genetic instability; and iii) in vitro cell transformation and in vivo carcinogenesis.Modelling is still under-utilized and under-developed in clinical virology and cancer research; however, it is expected to play a significant role in the future, aiming to elucidate the cancer enigma. This article is based on a webinar on neuroblastoma in children, which was organised virtually on

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Section: Question: How Is Your Model Evaluated In the Following Years?mentioning

confidence: 99%

Neuroblastoma in childhood and its potential viral involvement: A webinar by the Paediatric Virology Study Group

Rovigatti

Papaioannou

Mammas³

et al. 2022

World Acad Sci J

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Occurrence of reovirus antibodies in healthy African children and in children with Burkitt's lymphoma

Levy

Tanabe

Curnen

1968

Cancer

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Hemagglutination‐inhibition tests with sera from both healthy African children and those with Burkitt's lymphoma indicate a high and relatively uniform prevalence of reovirus type 1 and type 2 antibodies. The occurrence of reovirus type 3 antibody is low in healthy children but high in patients with Burkitt's lymphoma. The importance of these findings in relation to the etiology of Burkitt's lymphoma is discussed.

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Evidence for viruses in acute leukemia and Burkitt's tumor

Henle

1968

Cancer

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On the basis of experience with oncogenic animal viruses it is likely that at least some human malignancies are virus‐induced. The problems to be faced in assigning an oncogenic potential to a human virus have been discussed and illustrated by observations made on the herpes‐type virus which frequently is associated with cultured cells of the hematopoietic system. This virus seems to fulfill some of the criteria established for transformation of normal cells by oncogenic animal viruses yet the present information is insufficient to prove an etiologic relationship of the herpes‐type virus to Burkitt's lymphoma or other tumors of the hematopoietic system.

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Further Isolations of Reovirus Type 3 from Cases of Burkitt's Lymphoma

Cited by 42 publications

References 23 publications

Neuroblastoma in childhood and its potential viral involvement: A webinar by the Paediatric Virology Study Group

Neuroblastoma in childhood and its potential viral involvement: A webinar by the Paediatric Virology Study Group

Occurrence of reovirus antibodies in healthy African children and in children with Burkitt's lymphoma

Evidence for viruses in acute leukemia and Burkitt's tumor

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