Further mapping of quantitative trait loci for postnatal growth in an intersubspecific backcross of wild <i>Mus musculus castaneus</i> and C57BL/6J mice

Ishikawa, Akira; Hatada, Sayuri; NAGAMINE, YOSHITAKA; Namikawa, Takao

doi:10.1017/s0016672305007652

Cited by 4 publications

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“…These findings suggest a chromosomal region with a predominantly additive effect on the whole pre-adult growth phase in mice. In addition, we confirmed the observations of Ishikawa et al (2005) and Vaughn et al (1999) that postnatal and later growth are regulated in part by different genes. The multiple effect on Chr 1 was predominantly made up of body weight at 4, 5 and 6 weeks, while on Chr 3 only bw2 and bw3 contributed significantly to the detected effect.…”

Section: Discussionsupporting

confidence: 89%

“…However, in most studies mice at later ages than ours were examined or measurements were not made at weekly intervals, which makes a comparison with our data problematic. In contrast, Ishikawa et al (2005) reported a single QTL on Chr 2 affecting the whole investigated growth phase of 3 to 10 weeks. This chromosomal region overlapped with the multiple-trait QTL which Table 4.…”

Section: Discussionmentioning

confidence: 84%

“…There has been little investigation of growth regulation during the suckling period (1-3 weeks of age) or after weaning (3-6 weeks of age). To date, the genetic determination of murine growth at the age of 1-10 weeks has seldom been examined, for example in crosses between the mouse line LG/J selected for large body size and fatness and SM/J selected for small body size (Cheverud et al, 1996(Cheverud et al, , 2001Vaughn et al, 1999) and in a backcross population of wild mice and C57BL/6J (Ishikawa et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice

2007

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Multiple-trait analyses have been shown to improve the detection of quantitative trait loci (QTLs) with multiple effects. Here we applied a multiple-trait approach on obesity- and growth-related traits that were surveyed in 275 F2 mice generated from an intercross between the high body weight selected line NMRI8 and DBA/2 as lean control. The parental lines differed 2.5-fold in body weight at the age of 6 weeks. Within the F2 population, the correlations between body weight and weights of abdominal fat weight, muscle, liver and kidney at the age of 6 weeks were about 0.8. A least squares multiple-trait QTL analysis was performed on these data to understand more precisely the cause of the genetic correlation between body weight, body composition traits and weights of inner organs. Regions on Chr 1, 2, 7 and 14 for body weights at different early ages and regions on Chr 1, 2, 4, 7, 14, 17 and 19 for organ weights at 6 weeks were found to have significant multiple effects at the genome-wide level.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice

2007

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“…Our previous genome-wide QTL studies revealed 24 QTLs for postnatal body weight and growth in an intersubspecific backcross mouse population between C57BL/6J (B6), a common inbred strain, and wild Mus musculus castaneus mice captured in the Philippines (Ishikawa et al 2000(Ishikawa et al , 2005Ishikawa & Namikawa 2004). We developed the congenic strain B6.Cg-Pbwg1 on the B6 genetic background with a 44.1-Mb wildderived genomic region containing Pbwg1, the most potent growth QTL on mouse chromosome 2 among the 24 QTLs (Ishikawa et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Fine mapping of quantitative trait loci affecting organ weights by mouse intersubspecific subcongenic strain analysis

Mollah

Ishikawa

2012

Animal Science Journal

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The genetic architecture of organ weights is not well understood. In this study, we fine-mapped quantitative trait loci (QTLs) affecting organ weights by characterizing six intersubspecific subcongenic mouse strains with overlapping and non-overlapping genomic regions on chromosome 2 derived from wild Mus musculus castaneus. QTLs for heart, lung, spleen and kidney weights were revealed on a 6.38-Mb genomic region between two microsatellite markers, D2Mit323 and D2Mit472. Effects of the castaneus alleles at the organ weight QTLs were all opposite in direction to a body weight QTL previously mapped to the same genomic region. In addition, new QTLs for lung and kidney weights were revealed on a different 3.57-Mb region between D2Mit205 and D2Mit182. Their effects were dependent on that of another body weight QTL previously mapped to that genomic region. The organ weight QTLs revealed were all duplicated in independent analyses with F2 intercross populations between subcongenic strains carrying these QTLs and their background strain. The findings suggested that organ weights are not exclusively regulated by genetic loci that commonly influence overall body weight and rather that there are loci contributing to the growth of specific organs only.

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“…Body weight and fatness are quantitative traits of agricultural and medical importance and they have long been used in the mouse as archetypal model quantitative traits since the 1940s (Eisen 2005). In our previous genome-wide QTL analyses, 24 QTLs for body weight and growth at 3-10 weeks after birth have been mapped on 13 mouse chromosomes in an intersubspecific backcross population between wild subspecies mice, Mus musculus castaneus, captured in the Philippines and the common inbred strain C57BL/6J (Ishikawa et al 2000(Ishikawa et al , 2005Ishikawa & Namikawa 2004). Among the 24 QTLs mapped, two QTLs, named Pbwg9 and Pbwg16, are localized on chro-mosome 10.…”

Section: Introductionmentioning

confidence: 99%

A proximal genomic region of mouse chromosome 10 contains quantitative trait loci affecting fatness

Ishikawa

Tanahashi

Kodama

2011

Animal Science Journal

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Body weight and fatness are quantitative traits of agricultural and medical importance. In previous genome-wide quantitative trait locus (QTL) analyses, two QTLs for body weight and weight gain at an early postnatal growth period were discovered on mouse chromosome 10 from a gene pool of wild subspecies mice, Mus musculus castaneus. In this study, we developed a congenic strain with an approximately 63-Mb wild-derived genomic region on which the two growth QTLs could be located, by recurrent backcrossing to the common inbred strain C57BL/6J. We compared body weights at 1-10 weeks of age, body weight gains at 1-3, 3-6 and 6-10 weeks, internal organ weights and body lengths between the congenic strain developed and C57BL/6J. Unfortunately, no effects of the two growth QTLs on body weights and weight gains were confirmed. However, at least two new QTLs affecting fatness traits were discovered within the introgressed congenic region. The wild-derived allele at one QTL increased body mass index, whereas at another one it decreased white fat pad weight and adiposity index. Thus, the congenic mouse strain developed here is a useful model animal for understanding the genetic and molecular basis of fat deposition in livestock as well as humans.

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Further mapping of quantitative trait loci for postnatal growth in an intersubspecific backcross of wild Mus musculus castaneus and C57BL/6J mice

Abstract: We regret that in the article by Akira Ishikawa et al. in Genetical Research (2005) Vol. 85, No. 2, pp. 127–137, Fig. 1 on page 131 should have been reproduced in colour, not in black and white. Please find the correct version below.

Cited by 4 publications

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Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice

Multiple-trait QTL mapping for body and organ weights in a cross between NMRI8 and DBA/2 mice

Fine mapping of quantitative trait loci affecting organ weights by mouse intersubspecific subcongenic strain analysis

A proximal genomic region of mouse chromosome 10 contains quantitative trait loci affecting fatness

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