Further measurements on the activity of vasodilator substances

Ja, Gillespie

doi:10.1002/bjs.18005022312

Cited by 5 publications

(3 citation statements)

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“…J., 1969). In particular there is considerable evidence of its inefficacy in the treatment of occlusive arterial disease (Gillespie, 1959(Gillespie, , 1963Zetterquist, 1968), though the case against it in non-occlusive disease is less certainly agreed. Recently a new and highly specific alphablocking agent, thymoxamine hydrochloride (Opilon : Warner), has been advocated as having a specific cutaneous vasodilator action (Birmingham and Szolcsanyi, 1965).…”

Section: Methodsmentioning

confidence: 96%

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Evaluation of a new alpha-blocking vasodilator agent (thymoxamine) in peripheral vascular disease

Kane¹

1970

Journal of British Surgery

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The effects on peripheral cutaneous blood‐flow of the alpha‐receptor blocking drug thymoxamine were measured by strain‐gauge plethysmography in 58 subjects. The intravenous drug produced a substantial, though often transient, vasodilatation in the feet of normal subjects, and in most instances increased pedal blood‐flow in non‐sympathectomized patients with lower‐limb arterial occlusions and healthy feet. In patients previously sympathectomized for either non‐occlusive or occlusive disease of the lower limbs the effect of the drug was variable, even bringing about a reduction in pedal blood‐flow in a number of cases. Intravenous thymoxamine regularly though briefly produced vasodilatation in the hands of patients sympathectomized for primary Raynaud'S disease, but the oral drug had no such action in most instances. It is concluded that systemic thymoxamine is unlikely to be of therapeutic benefit to the sympathecromized patient.

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Section: Methodsmentioning

confidence: 96%

“…Extrinsic, sympathetically mediated, vasomotor tone, however, rarely returns to the foot, even many years after sympathectomy (Gillespie, 1961), and this could account for the poor response of most of these patients to intravenous thymoxamine.…”

Section: The Effect Of Intravenous Thymoxamine On Skin Blood-flow In mentioning

confidence: 93%