Further observations on the effects of dietary fatty acid composition on platelet reactivity and blood coagulation in man and the influence of methodology on findings

Jakubowski, J.A.; Ardlie, N.G.; Morgan, Francis J.; Chesterman, C N

doi:10.1016/0021-9150(82)90193-9

Cited by 6 publications

(1 citation statement)

References 33 publications

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“…Their concentrations in plasma are regarded as useful indicators of in vivo platelet activation and release reaction [54]. The plasma levels are influenced by dietary fatty acids [55][56][57]. EPO intake caused a decrease in the plasma levels of both compounds, which was most pronounced in the diabetic group.…”

Section: Platelet Functionmentioning

confidence: 99%

Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, α-tocopherol levels, and erythropoiesis in normal and Type 1 (insulin-dependent) diabetic men

et al. 1988

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In addition to their usual diet, nine Type 1 (insulin-dependent) diabetic men and ten male control subjects took 20 g d, alpha-tocopheryl acetate enriched evening primrose oil (14.45 g 18:2c,omega 6, 1.73 g 18:3c,omega 6, 400 mg d,alpha-tocopheryl acetate) daily for one week. At start, diabetic patients had more 14:0, 15:0 and 18:2c,omega 6, and less 16:0, 16:1c,omega 7, 18:1c,omega 7, 18:3c,omega 6, 20:3c,omega 9, 20:3c,omega 6, 20:4c,omega 6 and 22:6c,omega 3 in plasma, erythrocytes and/or platelets. Furthermore, they had lower 16:1c,omega 7/16:0, 18:1c,omega 7/16:0, and 20:4c,omega 6/20:3c,omega 6 ratios and a higher 20:3c,omega 6/18:3c,omega 6 ratio. In diabetic patients, alpha-tocopherol levels in erythrocytes were lower, whereas those in plasma were normal. In both groups, oil intake changed fatty acid profiles. Most markedly, 20:3c,omega 6 increased, whereas the ratios 20:3c,omega 6/18:3c,omega 6 and 20:4c,omega 6/20:3c,omega 6 decreased. 20:4c,omega 6 increased in control subjects, but not in diabetic patients. Erythrocytes and platelets responded differently in their fatty acid profiles. alpha-tocopherol rose in plasma and, although less for diabetic patients, in erythrocytes. In diabetic patients as well as in control subjects, erythrocyte count, haemoglobin level, mean corpuscular haemoglobin content and concentration increased and glycosylated haemoglobin percentage decreased without an apparent decline in blood glucose levels. Plasma beta-thromboglobulin and platelet factor 4 decreased, especially in diabetic patients.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Platelet Functionmentioning

confidence: 99%

Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, α-tocopherol levels, and erythropoiesis in normal and Type 1 (insulin-dependent) diabetic men

et al. 1988

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The Effect of Weight Reduction on the Lipid Composition of Human Plasma and Thrombocytes

Pucsok¹,

Morava²

1987

Fett/Lipid

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The effect of one week hospital and subsequent two months ambulatory dietary treatment was studied on lipid parameters of sera, on phospholipid composition of plasma and platelets, and on platelet aggregation. In the first phase the serum triglyceride level decreased significantly, but no further change could be shown later. Serum cholesterol decreased significantly during the hospitalization and remained on this level after the ambulatory treatment. HDL‐cholesterol didn't change at first, but later rose significantly. Following the ambulatory treatment a decreasing tendency can be seen, in plasma total phospholipids, but at the end of the two months it approaches the baseline value. The platelet phospholipid content didn't change during the first week, but later reduced significantly. Platelet aggregation decreased, but it was pronounced only after the two months' dietary period.

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Acute postprandial lipaemia does not influence the activity of human platelets

Jakubowski

Ardlie

Chesterman

et al. 1985

Thrombosis Research

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Further observations on the effects of dietary fatty acid composition on platelet reactivity and blood coagulation in man and the influence of methodology on findings

Cited by 6 publications

References 33 publications

Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, α-tocopherol levels, and erythropoiesis in normal and Type 1 (insulin-dependent) diabetic men

Effects of short-term high dose intake of evening primrose oil on plasma and cellular fatty acid compositions, α-tocopherol levels, and erythropoiesis in normal and Type 1 (insulin-dependent) diabetic men

The Effect of Weight Reduction on the Lipid Composition of Human Plasma and Thrombocytes

Acute postprandial lipaemia does not influence the activity of human platelets

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